Transcranial sonography findings in spinocerebellar ataxia type 3 (Machado-Joseph disease): A cross-sectional study

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorPEDROSO, Jose Luiz
dc.contributor.authorBOR-SENG-SHU, Edson
dc.contributor.authorFELICIO, Andre Carvalho
dc.contributor.authorBRAGA-NETO, Pedro
dc.contributor.authorTEIXEIRA, Manoel Jacobsen
dc.contributor.authorBARSOTTINI, Orlando Graziani
dc.date.accessioned2017-11-27T16:29:02Z
dc.date.available2017-11-27T16:29:02Z
dc.date.issued2011
dc.description.abstractFew studies on transcranial brain sonography have been performed in hereditary and non-hereditary ataxias. The objective of the present study was to report transcranial brain sonography findings in a sample of clinically and molecularly proven Machado-Joseph disease patients and to compare these data against those of an age- and gender-matched control group. A cross-sectional study on transcranial brain sonography was conducted in 30 Machado-Joseph disease patients. Transcranial brain sonography was performed by an experienced sonographer blinded to the clinical, genetic, and neuroimaging data. The results were compared with those of a control group of 44 healthy subjects matched for age and gender. The sonographic findings were also correlated with clinical features and genetic data in Machado-Joseph disease group. A significantly higher frequency of substantia nigra and lenticular nucleus hyperechogenicity was found in the Machado-Joseph disease group compared to an age- and gender-matched healthy control group (p < 0.001). The substantia nigra echogenic area proved to be the best predictor for differentiating cases from controls. Third and lateral ventricles were significantly larger in the Machado-Joseph disease patients than in the control subjects. No significant correlations were found between transcranial brain sonography findings and Machado-Joseph disease demographic/clinical data. Transcranial brain sonography findings in Machado-Joseph disease patients differed significantly to those in age- and gender-matched controls. Substantia nigra hyperechogenicity occurred frequently in Machado-Joseph disease patients and was found to be the best predictor for differentiating cases from controls. Additionally, this data describes the occurrence of brain atrophy in Machado-Joseph disease group.
dc.description.indexMEDLINE
dc.identifier.citationNEUROSCIENCE LETTERS, v.504, n.2, p.98-101, 2011
dc.identifier.doi10.1016/j.neulet.2011.09.006
dc.identifier.issn0304-3940
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/23152
dc.language.isoeng
dc.publisherELSEVIER IRELAND LTD
dc.relation.ispartofNeuroscience Letters
dc.rightsrestrictedAccess
dc.rights.holderCopyright ELSEVIER IRELAND LTD
dc.subjectSpinocerebellar ataxia type 3
dc.subjectMachado-Joseph disease
dc.subjectTranscranial sonography
dc.subjectSubstantia nigra hyperechogenicity
dc.subjectBrain ultrasound
dc.subject.otherbrain parenchyma sonography
dc.subject.otherreal-time sonography
dc.subject.otherparkinsons-disease
dc.subject.othermovement-disorders
dc.subject.othersubstantia-nigra
dc.subject.otherhuntingtons-disease
dc.subject.otherultrasound
dc.subject.otherechogenicity
dc.subject.otherpathogenesis
dc.subject.othertranslation
dc.subject.wosNeurosciences
dc.titleTranscranial sonography findings in spinocerebellar ataxia type 3 (Machado-Joseph disease): A cross-sectional study
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalPEDROSO, Jose Luiz:Univ Fed Sao Paulo, Dept Neurol & Neurosurg, Sao Paulo, Brazil
hcfmusp.author.externalFELICIO, Andre Carvalho:Univ Fed Sao Paulo, Dept Neurol & Neurosurg, Sao Paulo, Brazil
hcfmusp.author.externalBRAGA-NETO, Pedro:Univ Fed Sao Paulo, Dept Neurol & Neurosurg, Sao Paulo, Brazil
hcfmusp.author.externalBARSOTTINI, Orlando Graziani:Univ Fed Sao Paulo, Dept Neurol & Neurosurg, Sao Paulo, Brazil
hcfmusp.citation.scopus19
hcfmusp.contributor.author-fmusphcEDSON BOR-SENG SHU
hcfmusp.contributor.author-fmusphcMANOEL JACOBSEN TEIXEIRA
hcfmusp.description.beginpage98
hcfmusp.description.endpage101
hcfmusp.description.issue2
hcfmusp.description.volume504
hcfmusp.origemWOS
hcfmusp.origem.pubmed21939734
hcfmusp.origem.scopus2-s2.0-80054005992
hcfmusp.origem.wosWOS:000297535000005
hcfmusp.publisher.cityCLARE
hcfmusp.publisher.countryIRELAND
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