False-negative result of serum cryptococcal antigen lateral flow assay in an HIV-infected patient with culture-proven cryptococcaemia

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art_BORGES_Falsenegative_result_of_serum_cryptococcal_antigen_lateral_flow_2019.PDF (573.45 KB)
Citações na Scopus
13
Tipo de produção
article
Data de publicação
2019
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
ELSEVIER
Autores
BORGES, Moara Alves Santa Barbara
ARAUJO FILHO, Joao Alves de
SOARES, Renata de Bastos Ascenco
TURCHI, Marllia Dalva
Citação
MEDICAL MYCOLOGY CASE REPORTS, v.26, p.64-66, 2019
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
The detection of cryptococcal capsular antigen (CrAg) is very sensitive and specific, however false-negative results have been reported, mostly in cerebrospinal fluid. We report the case of an HIV-infected patient with CD4 = 42 cells/mL, asthenic, negative serum CrAg lateral flow assay (LFA) and culture-proven cryptococcaemia. Despite the high accuracy of LFA, false-negative result is possible. Careful clinical evaluation and close follow-up are relevant.
Palavras-chave
Cryptococcosis, AIDS, Fungal antigens, False negative reaction, Prozone effect
URI
https://observatorio.fm.usp.br/handle/OPI/34622
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Coleções
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/49
Artigos e Materiais de Revistas Científicas - ODS/03