Aerobic Exercise Modulates Visceral Adipose Tissue of Estrogen Deprived Rats in an Experimental Model of Dyslipidemia

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorMAGALHAES, Walkyria Villegas
dc.contributor.authorCHUCATA, Kemily Loren Barros
dc.contributor.authorDSOUKI, Nuha Ahmad
dc.contributor.authorNUCCI, Ricardo Aparecido Baptista
dc.contributor.authorVELOSO, Aparecida Gabriela Bexiga
dc.contributor.authorFONSECA, Fernando Luiz Affonso
dc.contributor.authorMAIFRINO, Laura Beatriz Mesiano
dc.date.accessioned2024-02-15T14:53:41Z
dc.date.available2024-02-15T14:53:41Z
dc.date.issued2024
dc.description.abstractIntroduction Menopausal women have an increase deposition of body fat and changes in the lipid profile, being especially susceptible to cardiovascular diseases, and type 2 diabetes. However, physical activity can mitigate this situation. Thus, the aim of the present study is to evaluate the effects of moderate aerobic exercise on visceral adipose tissue (VAT) of female LDL-receptor knockout ovariectomized mice.Methods We used 48 animals, divided into six groups ( n = 8/per group): sedentary control (SC), sedentary ovariectomized control (SCO), trained ovariectomized control (TCO), sedentary non-ovariectomized LDL-receptor knockout (KS), sedentary ovariectomized LDL-receptor knockout (KOS), and trained LDL-receptor knockout ovariectomized (KOT). We analyzed the VAT through morphometric and stereological parameters in hematoxylin and eosin stained sections. Additionally, we evaluated biochemical parameters as glucose, triglycerides, and total cholesterol. Finally, immunohistochemical techniques for matrix remodeling, inflammation, apoptosis, and oxidative stress were evaluated. Results We observed that menopause is related to increased visceral adiposity, inflammation, oxidative stress, macrophages activity, serum levels of glucose, triglycerides, and total cholesterol. However, exercise was effective in reducing these parameters, as well as being associated with increased vascularization of VAT and interstitial volume density. Conclusions Moderate exercise is a key factor in mitigating the effects of dyslipidemia in estrogen deprivation. However, further studies are needed to corroborate with our findings.eng
dc.description.indexWoS
dc.identifier.citationJOURNAL OF HEALTH AND ALLIED SCIENCES NU, v.14, n.1, p.71-77, 2024
dc.identifier.doi10.1055/s-0043-1762581
dc.identifier.eissn2582-4953
dc.identifier.issn2582-4287
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/58068
dc.language.isoeng
dc.publisherTHIEME MEDICAL PUBL INCeng
dc.relation.ispartofJournal of Health and Allied Sciences Nu
dc.rightsrestrictedAccesseng
dc.rights.holderCopyright THIEME MEDICAL PUBL INCeng
dc.subjectadiposityeng
dc.subjectdyslipidemiaeng
dc.subjectexperimentaleng
dc.subjectmenopauseeng
dc.subjecttreadmilleng
dc.subject.otheradipocyte sizeeng
dc.subject.otherlipid-metabolismeng
dc.subject.otherinflammationeng
dc.subject.otherdysfunctioneng
dc.subject.otherresistanceeng
dc.subject.otherobesityeng
dc.subject.otherlivereng
dc.subject.otheraortaeng
dc.subject.othermiceeng
dc.subject.wosMedicine, General & Internaleng
dc.titleAerobic Exercise Modulates Visceral Adipose Tissue of Estrogen Deprived Rats in an Experimental Model of Dyslipidemiaeng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.author.externalMAGALHAES, Walkyria Villegas:Univ Sao Judas Tadeu, Dept Phys Educ, Lab Morphol & Immunohistochem Studies, Rua Taquari, Mooca, SP, Brazil
hcfmusp.author.externalCHUCATA, Kemily Loren Barros:Univ Sao Judas Tadeu, Dept Phys Educ, Lab Morphol & Immunohistochem Studies, Rua Taquari, Mooca, SP, Brazil
hcfmusp.author.externalDSOUKI, Nuha Ahmad:ABC Dist Med Sch, Dept Morphol & Physiol, Av Lauro Gomes, Santo Andre, Brazil
hcfmusp.author.externalVELOSO, Aparecida Gabriela Bexiga:Oswaldo Cruz Sch, Dept Morphol, Rua Brigadeiro Galvao, Barra Funda, SP, Brazil
hcfmusp.author.externalFONSECA, Fernando Luiz Affonso:ABC Dist Med Sch, Lab Clin Anal, Av Lauro Gomes, Santo Andre, Brazil; Fed Univ Sao Paulo UNIFESP, Dept Pharmaceut Sci, Rua Sena Madureira, Sao Paulo, Brazil
hcfmusp.author.externalMAIFRINO, Laura Beatriz Mesiano:ABC Dist Med Sch, Lab Clin Anal, Av Lauro Gomes, Santo Andre, Brazil; Dante Pazzanese Inst Cardiol, Av Dr Dante Pazzanese, Sao Paulo, Brazil
hcfmusp.contributor.author-fmusphcRICARDO APARECIDO BAPTISTA NUCCI
hcfmusp.description.beginpage71
hcfmusp.description.endpage77
hcfmusp.description.issue1
hcfmusp.description.volume14
hcfmusp.origemWOS
hcfmusp.origem.wosWOS:000971689400002
hcfmusp.publisher.cityNEW YORKeng
hcfmusp.publisher.countryUSAeng
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