Association between family history of mood disorders and clinical characteristics of bipolar disorder: Results from the Brazilian bipolar research network

dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorBERUTTI, Mariangeles
dc.contributor.authorNERY, Fabiano G.
dc.contributor.authorSATO, Rodrigo
dc.contributor.authorSCIPPA, Angela
dc.contributor.authorKAPCZINSKI, Flavio
dc.contributor.authorLAFER, Beny
dc.date.accessioned2014-09-30T14:44:47Z
dc.date.available2014-09-30T14:44:47Z
dc.date.issued2014
dc.description.abstractObjectives: To compare clinical characteristics of bipolar disorder (BD) in patients with and without a family history of mood disorders (FHMD) in a large sample from the Brazilian Research Network of Bipolar Disorders, Methods: Four-hundred eighty-eight DSM-lV BD patients participating in the Brazilian Research Network of Bipolar Disorders were included. Participants were divided between those with FHMD (n=230) and without FHMD (n=258). We compared these two groups on demographic and clinical variables and performed a logistic regression to identify which variables were most strongly associated with positive family history of mood disorders. Results: BD patients with FHMD presented with significantly higher lifetime prevalence of any anxiety disorder, obsessive-compulsive disorder, social phobia, substance abuse, and were more likely to present history of suicide attempts, family history of suicide attempts and suicide, and more psychiatric hospitalizations than BD patients without FHMD. Logistic regression showed that the variables most strongly associated with a positive FHMD were any comorbid anxiety disorder, comorbid substance abuse, and family history of suicide. Limitations: Cross-sectional study and verification of FHMD by indirect information. Conclusion: BD patients with FHMD differ from BD patients without FHMD in rates of comorbid anxiety disorder and substance abuse, number of hospitalizations and suicide attempts. As FHMD is routinely assessed in clinical practice, these findings may help to identify patients at risk for particular manifestations of BD and may point to a common, genetically determined neurobiological substrate that increases the risk of conditions such as comorbidities and suicidality in BD patients.
dc.description.indexMEDLINE
dc.description.sponsorshipINCTTM
dc.description.sponsorshipCNPq
dc.description.sponsorshipCAPES
dc.description.sponsorshipFAPESP
dc.identifier.citationJOURNAL OF AFFECTIVE DISORDERS, v.161, p.104-108, 2014
dc.identifier.doi10.1016/j.jad.2014.02.045
dc.identifier.eissn1573-2517
dc.identifier.issn0165-0327
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/7649
dc.language.isoeng
dc.publisherELSEVIER SCIENCE BV
dc.relation.ispartofJournal of Affective Disorders
dc.rightsrestrictedAccess
dc.rights.holderCopyright ELSEVIER SCIENCE BV
dc.subjectBipolar disorder
dc.subjectFamily history
dc.subjectMood disorder
dc.subjectComorbidity
dc.subjectImpulsivity
dc.subject.othercomorbid anxiety disorders
dc.subject.othermajor depressive disorder
dc.subject.otherstar-asterisk-d
dc.subject.othersuicide attempts
dc.subject.othertrait impulsivity
dc.subject.othersubstance-abuse
dc.subject.otherpsychiatric comorbidity
dc.subject.otherspectrum disorder
dc.subject.otherrating-scale
dc.subject.otherrisk-factors
dc.subject.wosClinical Neurology
dc.subject.wosPsychiatry
dc.titleAssociation between family history of mood disorders and clinical characteristics of bipolar disorder: Results from the Brazilian bipolar research network
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalSCIPPA, Angela:Univ Fed Bahia, Dept Psychiat, Ctr Treatment Affect Disorders CETHA, Salvador, BA, Brazil
hcfmusp.author.externalKAPCZINSKI, Flavio:Univ Fed Rio Grande do Sul, Dept Psychiat, Bipolar Disorder Program PROTAHBI, Porto Alegre, RS, Brazil
hcfmusp.citation.scopus17
hcfmusp.contributor.author-fmusphcMARIANGELES BERUTTI
hcfmusp.contributor.author-fmusphcFABIANO GONCALVES NERY
hcfmusp.contributor.author-fmusphcRODRIGO HIDEHARO SATO
hcfmusp.contributor.author-fmusphcBENY LAFER
hcfmusp.description.beginpage104
hcfmusp.description.endpage108
hcfmusp.description.volume161
hcfmusp.origemWOS
hcfmusp.origem.pubmed24751316
hcfmusp.origem.scopus2-s2.0-84898761477
hcfmusp.origem.wosWOS:000334741200014
hcfmusp.publisher.cityAMSTERDAM
hcfmusp.publisher.countryNETHERLANDS
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