Assessing the efficacy and safety of hemangioblastoma embolization: A comprehensive systematic review and meta-analysis

Imagem de Miniatura
Arquivos
art_PALAVANI_Assessing_the_efficacy_and_safety_of_hemangioblastoma_embolization_2023.PDF (810.58 KB)
Citações na Scopus
1
Tipo de produção
article
Data de publicação
2023
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
ELSEVIER SCI LTD
Autores
PALAVANI, Lucca B.
ANDREAO, Filipi Fim
ABREU, Livia Viviani de
BATISTA, Savio
BORGES, Jordana
OLIVEIRA, Leonardo de Barros
ALMEIDA FILHO, Jose Alberto
Citação
JOURNAL OF CLINICAL NEUROSCIENCE, v.117, p.104-113, 2023
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Background: Hemangioblastomas (HBs) are highly vascular tumors linked to substantial morbidity and mortality. Recently, interventional neuroradiology has evolved rapidly, spurring interest in preoperative embolization as a possible HB treatment.Purpose: This study evaluates the effectiveness and safety of preoperative embolization in managing HB. Methods: Adhering to PRISMA guidelines, this meta-analysis considered randomized and nonrandomized studies meeting specific criteria, encompassing intracranial HB and preoperative embolization. Primary outcomes were preoperative embolization efficacy and safety. Complications were classified as major (cerebellar ischemia, ischemic strokes, intratumoral hemorrhage, subarachnoid hemorrhage) and minor (transient nystagmus, slight facial nerve palsy, nausea, transient dysarthria, hemiparesis, hemisensory impairment, thrombotic complica-tions, extravasation).Results: Thirteen studies involving 166 patients with preoperative embolization before HB resection were included. Two studies using the Glasgow Outcome Scale (GOS) showed 5 patients with good recovery, 6 with moderate disability, and 3 with severe disability. Major complications occurred in 1% (95% CI: 0% to 3%), and minor complications occurred in 1% (95% CI: 0% to 4%). Intraoperative blood loss during resection was esti-mated at 464.29 ml (95% CI: 350.63 ml to 614.80 ml).Conclusion: Preoperative embolization holds promise in reducing intraoperative bleeding risk in neurosurgical intracranial HB treatment, primarily due to its low complication rates. Nonetheless, additional research and larger-scale studies are essential to establish its long-term efficacy and safety. These findings highlight preop-erative embolization as a valuable tool for HB management, potentially enhancing future patient outcomes.
Palavras-chave
Hemangioblastoma, Embolization, Von Hippel Lindau, PVA, NBCA, Onyx
URI
https://observatorio.fm.usp.br/handle/OPI/57690
Referências
  1. Ahuja A, 1994, Neurosurg Clin N Am, V5, P541
  2. Ampie L, 2016, CLIN NEUROL NEUROSUR, V150, P143, DOI 10.1016/j.clineuro.2016.09.008
  3. Behzadi Faraz, 2022, J Cerebrovasc Endovasc Neurosurg, V24, P144, DOI 10.7461/jcen.2022.E2021.12.003
  4. Cornelius JF, 2007, J NEUROSURG, V106, P994, DOI 10.3171/jns.2007.106.6.994
  5. Cui H, 2017, ONCOL LETT, V13, P1125, DOI 10.3892/ol.2016.5531
  6. DELAMONTE SM, 1989, NEUROSURGERY, V25, P695, DOI 10.1227/00006123-198911000-00002
  7. Deshmukh VR, 2005, NEUROSURG CLIN N AM, V16, P411, DOI 10.1016/j.nec.2004.08.010
  8. Edstrom E, 2020, OPER NEUROSURG, V18, P496, DOI 10.1093/ons/opz236
  9. Ene CI, 2016, OPER NEUROSURG, V12, P135, DOI 10.1227/NEU.0000000000001014
  10. Eom KS, 2011, NEUROL NEUROCHIR POL, V45, P292
  11. Eskridge JM, 1996, AM J NEURORADIOL, V17, P525
  12. Fukushima T, 1998, NEUROL MED-CHIR, V38, P489, DOI 10.2176/nmc.38.489
  13. Gharios M, 2023, ACTA NEUROCHIR, V165, P2343, DOI 10.1007/s00701-023-05756-7
  14. Giammattei L, 2016, ACTA NEUROCHIR, V158, P1333, DOI 10.1007/s00701-016-2834-0
  15. Gore P, 2008, NEUROSURGERY, V62, P1204, DOI 10.1227/01.neu.0000333292.74986.ac
  16. Grüter BE, 2018, WORLD NEUROSURG, V117, pE204, DOI 10.1016/j.wneu.2018.05.241
  17. Han Q, 2020, FRONT ONCOL, V10, DOI 10.3389/fonc.2020.00151
  18. HORTON JA, 1989, AM J NEURORADIOL, V10, P203
  19. Li PL, 2021, J CLIN NEUROSCI, V90, P68, DOI 10.1016/j.jocn.2021.05.026
  20. Liu AH, 2013, ASIAN PAC J CANCER P, V14, P5179, DOI 10.7314/APJCP.2013.14.9.5179
  21. Malis LI, 2002, J NEUROSURG, V97, P1, DOI 10.3171/spi.2002.97.1.0001
  22. Montano N, 2008, J NEUROSURG, V108, P1063, DOI 10.3171/JNS/2008/108/5/1063
  23. Moscovici S, 2022, ACTA NEUROCHIR, V164, P1357, DOI 10.1007/s00701-021-04828-w
  24. Munyon C, 2011, J NEUROINTERV SURG, V3, P386, DOI 10.1136/jnis.2010.004366
  25. Murai Y, 2012, NEURORADIOLOGY, V54, P981, DOI 10.1007/s00234-011-0985-5
  26. Niu L, 2016, CLIN NEUROL NEUROSUR, V150, P59, DOI 10.1016/j.clineuro.2016.08.028
  27. Page MJ, 2021, PLOS MED, V18, DOI [10.1371/journal.pmed.1003583, 10.1136/bmj.n71]
  28. Pavesi G, 2008, J NEUROSURG SCI, V52, P29
  29. Pavesi G, 2010, ACTA NEUROCHIR, V152, P287, DOI 10.1007/s00701-009-0512-1
  30. Sakamoto N, 2012, NEUROL MED-CHIR, V52, P878, DOI 10.2176/nmc.52.878
  31. Shin Gi Won, 2014, Neurointervention, V9, P45, DOI 10.5469/neuroint.2014.9.1.45
  32. Slim K, 2003, ANZ J SURG, V73, P712, DOI 10.1046/j.1445-2197.2003.02748.x
  33. STANDARD SC, 1994, SURG NEUROL, V41, P405, DOI 10.1016/0090-3019(94)90035-3
  34. Sugiu K, 2019, NEUROL MED-CHIR, V59, P41, DOI 10.2176/nmc.st.2018-0220
  35. Sultan A, 2016, INTERV NEURORADIOL, V22, P482, DOI 10.1177/1591019916633244
  36. Takeuchi S, 2001, NEUROL MED-CHIR, V41, P246, DOI 10.2176/nmc.41.246
  37. VazquezAnon V, 1997, NEURORADIOLOGY, V39, P86, DOI 10.1007/s002340050372
  38. Wan JQ, 2011, J CLIN NEUROSCI, V18, P39, DOI 10.1016/j.jocn.2010.07.099
  39. Wu PF, 2013, CLIN NEUROL NEUROSUR, V115, P651, DOI 10.1016/j.clineuro.2012.07.026
  40. Zhou LF, 2005, SURG NEUROL, V63, P307, DOI 10.1016/j.surneu.2004.07.038

Coleções
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - ODS/03