Urinary metabolic biomarkers of diet quality in European children are associated with metabolic health

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art_STRATAKIS_Urinary_metabolic_biomarkers_of_diet_quality_in_European_2022.PDF (630.95 KB)
Citações na Scopus
5
Tipo de produção
article
Data de publicação
2022
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
eLIFE SCIENCES PUBL LTD
Autores
STRATAKIS, Nikos
SISKOS, Alexandros P.
PAPADOPOULOU, Eleni
NGUYEN, Anh N.
ZHAO, Yinqi
MARGETAKI, Katerina
LAU, Chung-Ho E.
COEN, Muireann
MAITRE, Lea
FERNANDEZ-BARRES, Silvia
Citação
ELIFE, v.11, article ID e71332, 20p, 2022
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Urinary metabolic profiling is a promising powerful tool to reflect dietary intake and can help understand metabolic alterations in response to diet quality. Here, we used H-1 NMR spectroscopy in a multicountry study in European children (1147 children from 6 different cohorts) and identified a common panel of 4 urinary metabolites (hippurate, N-methylnicotinic acid, urea, and sucrose) that was predictive of Mediterranean diet adherence (KIDMED) and ultra-processed food consumption and also had higher capacity in discriminating children's diet quality than that of established sociodemographic determinants. Further, we showed that the identified metabolite panel also reflected the associations of these diet quality indicators with C-peptide, a stable and accurate marker of insulin resistance and future risk of metabolic disease. This methodology enables objective assessment of dietary patterns in European child populations, complementary to traditional questionary methods, and can be used in future studies to evaluate diet quality. Moreover, this knowledge can provide mechanistic evidence of common biological pathways that characterize healthy and unhealthy dietary patterns, and diet-related molecular alterations that could associate to metabolic disease.
Palavras-chave
metabolomics, NMR spectroscopy, mediterranean diet adherence, ultra-processed food intake, european children, Human
URI
https://observatorio.fm.usp.br/handle/OPI/46293
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Coleções
Artigos e Materiais de Revistas Científicas - LIM/38