Locus coeruleus volume and cell population changes during Alzheimer's disease progression: A stereological study in human postmortem brains with potential implication for early-stage biomarker discovery

Imagem de Miniatura
Arquivos
art_THEOFILAS_Locus_coeruleus_volume_and_cell_population_changes_during_2017.PDF (1.67 MB)
Citações na Scopus
231
Tipo de produção
article
Data de publicação
2017
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
ELSEVIER SCIENCE INC
Autores
THEOFILAS, Panos
EHRENBERG, Alexander J.
DUNLOP, Sara
NGUY, Austin
MEJIA, Maria B.
FERRETTI-REBUSTINI, Renata Eloah De Lucena
Citação
ALZHEIMERS & DEMENTIA, v.13, n.3, p.236-246, 2017
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Introduction: Alzheimer's disease (AD) progression follows a specific spreading pattern, emphasizing the need to characterize those brain areas that degenerate first. The brainstem's locus coeruleus (LC) is the first area to develop neurofibrillary changes (neurofibrillary tangles [NFTs]). Methods: The methods include unbiased stereologiCal analyses in human brainstems to estimate LC volume and neuronal population in controls and individuals across all AD stages. Results: As the Braak stage increases by 1 unit, the LC volume decreases by 8.4%. Neuronal loss started only midway through AD progression. Age-related changes spare the LC. Discussion: The long gap between NFT accumulation and neuronal loss suggests that a second trigger may be necessary to induce neuronal death in AD. Imaging studies should determine whether LC volumetry can replicate the stage-wise atrophy observed here and how these changes are specific to AD. LC volumetry may develop into a screening biomarker for selecting high-yield candidates to undergo expensive and less accessible positron emission tomography scans and to monitor AD progression from presymptomatic stages.
Palavras-chave
Alzheimer's disease, Brainstem, Locus coeruleus, Human, Neurofibrillary tangles, Unbiased stereology, Postmortem, Neuron counts, Volumetry
URI
https://observatorio.fm.usp.br/handle/OPI/18728
Referências
  1. Andrade-Moraes CH, 2013, BRAIN, V136, P3738, DOI 10.1093/brain/awt273
  2. Arendt T, 2015, ACTA NEUROPATHOL COM, V3, DOI 10.1186/s40478-015-0187-1
  3. Berridge CW, 2003, BRAIN RES REV, V42, P33, DOI 10.1016/S0165-0173(03)00143-7
  4. BRAAK H, 1991, ACTA NEUROPATHOL, V82, P239
  5. Braak H, 2011, J NEUROPATH EXP NEUR, V70, P960, DOI 10.1097/NEN.0b013e318232a379
  6. Braak H, 2011, ACTA NEUROPATHOL, V121, P171, DOI 10.1007/s00401-010-0789-4
  7. Busch C, 1997, NEUROBIOL AGING, V18, P401, DOI 10.1016/S0197-4580(97)00035-3
  8. Chalermpalanupap T, 2013, ALZHEIMERS RES THER, V5, DOI 10.1186/alzrt175
  9. CHANPALAY V, 1989, J COMP NEUROL, V287, P357, DOI 10.1002/cne.902870307
  10. CHANPALAY V, 1989, J COMP NEUROL, V287, P373, DOI 10.1002/cne.902870308
  11. Cleveland W.S., 1981, T AM STAT, V35, P54, DOI 10.2307/2683591
  12. Deistung A, 2013, FRONT HUM NEUROSCI, V7, DOI 10.3389/fnhum.2013.00710
  13. Duyckaerts C, 2009, ACTA NEUROPATHOL, V118, P5, DOI 10.1007/s00401-009-0532-1
  14. Feinstein DL, 2002, NEUROCHEM INT, V41, P357, DOI 10.1016/S0197-0186(02)00049-9
  15. Ferretti Renata Eloah de Lucena, 2010, Dement. neuropsychol., V4, P138, DOI 10.1590/S1980-57642010DN40200011
  16. GERMAN DC, 1992, ANN NEUROL, V32, P667, DOI 10.1002/ana.410320510
  17. Gompf HS, 2010, J NEUROSCI, V30, P14543, DOI 10.1523/JNEUROSCI.3037-10.2010
  18. Grinberg LT, 2009, NEUROPATH APPL NEURO, V35, P406, DOI [10.1111/j.1365-2990.2009.00997.x, 10.1111/j.1365-2990.2008.00997.x]
  19. Grinberg Lea Tenenholz, 2007, Cell and Tissue Banking, V8, P151, DOI 10.1007/s10561-006-9022-z
  20. Grudzien A, 2007, NEUROBIOL AGING, V28, P327, DOI 10.1016/j.neurobiolaging.2006.02.007
  21. Gundersen HJG, 1999, J MICROSC-OXFORD, V193, P199, DOI 10.1046/j.1365-2818.1999.00457.x
  22. Hahn EA, 2014, AM J GERIAT PSYCHIAT, V22, P1262, DOI 10.1016/j.jagp.2013.04.015
  23. Heinsen H, 2000, J CHEM NEUROANAT, V20, P49, DOI 10.1016/S0891-0618(00)00067-3
  24. Heneka MT, 2010, P NATL ACAD SCI USA, V107, P6058, DOI 10.1073/pnas.0909586107
  25. HOOGENDIJK WJG, 1995, BRAIN, V118, P131, DOI 10.1093/brain/118.1.131
  26. Hurd MD, 2013, NEW ENGL J MED, V369, P489, DOI 10.1056/NEJMc1305541
  27. Iba M, 2015, ACTA NEUROPATHOL, V130, P349, DOI 10.1007/s00401-015-1458-4
  28. Iqbal K, 2014, BIOCHEM PHARMACOL, V88, P631, DOI 10.1016/j.bcp.2014.01.002
  29. ISHII T, 1966, ACTA NEUROPATHOL, V6, P181
  30. Korczyn AD, 2012, J ALZHEIMERS DIS, V29, P275, DOI 10.3233/JAD-2011-110359
  31. LOUGHLIN SE, 1986, NEUROSCIENCE, V18, P291, DOI 10.1016/0306-4522(86)90155-7
  32. Lyness SA, 2003, NEUROBIOL AGING, V24, P1, DOI 10.1016/S0197-4580(02)00057-X
  33. MANAYE KF, 1995, J COMP NEUROL, V358, P79, DOI 10.1002/cne.903580105
  34. MANN DMA, 1985, NEUROSCI LETT, V56, P51, DOI 10.1016/0304-3940(85)90439-2
  35. MARCYNIUK B, 1986, NEUROSCI LETT, V64, P247, DOI 10.1016/0304-3940(86)90336-8
  36. Masters MC, 2015, NEUROLOGY, V84, P617, DOI 10.1212/WNL.0000000000001238
  37. Montine TJ, 2012, ACTA NEUROPATHOL, V123, P1, DOI 10.1007/s00401-011-0910-3
  38. Olszewski J, 1982, CYTOARCHITECTURE HUM
  39. Pace-Schott EF, 2002, NAT REV NEUROSCI, V3, P591, DOI 10.1038/nrn895
  40. Panegyres Peter K, 2013, Am J Neurodegener Dis, V2, P300
  41. PFEFFERBAUM A, 1994, ARCH NEUROL-CHICAGO, V51, P874
  42. Robertson IH, 2013, NEUROBIOL AGING, V34, P298, DOI 10.1016/j.neurobiolaging.2012.05.019
  43. Samuels ER, 2008, CURR NEUROPHARMACOL, V6, P235, DOI 10.2174/157015908785777229
  44. SAPER CB, 1987, NEUROSCIENCE, V23, P389, DOI 10.1016/0306-4522(87)90063-7
  45. Sara SJ, 2012, NEURON, V76, P130, DOI 10.1016/j.neuron.2012.09.011
  46. Schmitz C, 2005, NEUROSCIENCE, V130, P813, DOI 10.1016/j.neuroscience.2004.08.050
  47. Seeley WW, 2009, NEURON, V62, P42, DOI 10.1016/j.neuron.2009.03.024
  48. Simic G, 2009, NEUROPATH APPL NEURO, V35, P532, DOI 10.1111/j.1365-2990.2009.01038.x
  49. Stratmann K, 2016, BRAIN PATHOL, V26, P371, DOI 10.1111/bpa.12289
  50. Teipel S, 2014, NEUROBIOL AGING, V35, P482, DOI 10.1016/j.neurobiolaging.2013.09.029
  51. Theofilas P, 2015, J ALZHEIMERS DIS, V46, P17, DOI 10.3233/JAD-142682
  52. Theofilas P, 2014, J NEUROSCI METH, V226, P171, DOI 10.1016/j.jneumeth.2014.01.030
  53. TOMLINSON BE, 1981, J NEUROL SCI, V49, P419, DOI 10.1016/0022-510X(81)90031-9
  54. TOMONAGA M, 1983, J NEUROL, V230, P231, DOI 10.1007/BF00313699
  55. VIJAYASHANKAR N, 1979, J NEUROPATH EXP NEUR, V38, P490, DOI 10.1097/00005072-197909000-00004
  56. Weinshenker D, 2008, CURR ALZHEIMER RES, V5, P342, DOI 10.2174/156720508784533286
  57. WESTLUND KN, 1980, BRAIN RES REV, V2, P235, DOI 10.1016/0165-0173(80)90009-0
  58. Zarow C, 2003, ARCH NEUROL-CHICAGO, V60, P337, DOI 10.1001/archneur.60.3.337

Coleções
Artigos e Materiais de Revistas Científicas - FM/MCM
Artigos e Materiais de Revistas Científicas - FM/MNE
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/15
Artigos e Materiais de Revistas Científicas - LIM/22
Artigos e Materiais de Revistas Científicas - LIM/44