HLA Markers for Poor Prognosis in Systemic Sclerosis Brazilian Patients

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorRIO, Ana Paula Toledo Del
dc.contributor.authorSACHETTO, Zoraida
dc.contributor.authorSAMPAIO-BARROS, Percival Degrava
dc.contributor.authorMARQUES-NETO, Joao Francisco
dc.contributor.authorLONDE, Ana Carolina Santos
dc.contributor.authorBERTOLO, Manoel Barros
dc.date.accessioned2014-01-28T22:30:08Z
dc.date.available2014-01-28T22:30:08Z
dc.date.issued2013
dc.description.abstractObjectives. The aim of this study was to evaluate human leukocyte antigen (HLA) involvement in the disease expression and poor prognostic clinical features (pulmonary fibrosis and pulmonary arterial hypertension) in patients diagnosed with systemic sclerosis (SSc) in a multiethnic population. Methods. SSc patients followed up between 2008 and 2011 were included, and clinical data were obtained through records review. Molecular HLA typing was performed (polymerase chain reaction amplification technique using specific primer sequences). The statistical analysis involved Fisher's exact test and Pearson's corrected chi-square test. P values < 0.05 were considered significant. The delta method was used to estimate the variance of the prevalence ratio (PR). Results. A total of 141 patients (120 women and 21 men) with SSc were studied, including 33.3% with diffuse cutaneous SSc (dcSSc), 62.4% with limited cutaneous SSc (lcSSc), and 4.3% with sine scleroderma. Pulmonary fibrosis was present in 61 patients (43.3%), and the HLA-A*30 and DQB1*04 alleles were related to susceptibility. In contrast, the HLA-DRB1*01 and DQB1*05 alleles were protective. Pulmonary arterial hypertension was diagnosed in 19 patients (13.5%) and was associated with HLA-B*35 and C*04; in contrast, C*03 seemed to be protective. Conclusions. Our current study documents the association of some classes I and II HLA alleles with the most severe clinical manifestations in a multiethnic case series. Our findings differed slightly from the previous data in other populations.
dc.description.indexMEDLINE
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo-FAPESP [2008/58010-3]
dc.identifier.citationDISEASE MARKERS, p.73-78, 2013
dc.identifier.doi10.1155/2013/301415
dc.identifier.issn0278-0240
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/4439
dc.language.isoeng
dc.publisherHINDAWI PUBLISHING CORPORATION
dc.relation.ispartofDisease Markers
dc.rightsopenAccess
dc.rights.holderCopyright HINDAWI PUBLISHING CORPORATION
dc.subject.othermajor histocompatibility complex
dc.subject.othergenome-wide association
dc.subject.otherhla-dqb1 1st domain
dc.subject.otherpulmonary-hypertension
dc.subject.otherautoantibody response
dc.subject.othertopoisomerase-i
dc.subject.otherscleroderma
dc.subject.otherprevalence
dc.subject.otherfeatures
dc.subject.othersusceptibility
dc.subject.wosBiotechnology & Applied Microbiology
dc.subject.wosGenetics & Heredity
dc.subject.wosMedicine, Research & Experimental
dc.subject.wosPathology
dc.titleHLA Markers for Poor Prognosis in Systemic Sclerosis Brazilian Patients
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalRIO, Ana Paula Toledo Del:State Univ Campinas UNICAMP, Fac Med Sci, Dept Internal Med, Rheumatol Unit, Campinas, SP, Brazil
hcfmusp.author.externalSACHETTO, Zoraida:State Univ Campinas UNICAMP, Fac Med Sci, Dept Internal Med, Rheumatol Unit, Campinas, SP, Brazil
hcfmusp.author.externalMARQUES-NETO, Joao Francisco:State Univ Campinas UNICAMP, Fac Med Sci, Dept Internal Med, Rheumatol Unit, Campinas, SP, Brazil
hcfmusp.author.externalLONDE, Ana Carolina Santos:State Univ Campinas UNICAMP, Fac Med Sci, Dept Internal Med, Rheumatol Unit, Campinas, SP, Brazil
hcfmusp.author.externalBERTOLO, Manoel Barros:State Univ Campinas UNICAMP, Fac Med Sci, Dept Internal Med, Rheumatol Unit, Campinas, SP, Brazil
hcfmusp.citation.scopus9
hcfmusp.contributor.author-fmusphcPERCIVAL DEGRAVA SAMPAIO BARROS
hcfmusp.description.beginpage73
hcfmusp.description.endpage78
hcfmusp.description.volume2013
hcfmusp.origemWOS
hcfmusp.origem.pubmed24167351
hcfmusp.origem.scopus2-s2.0-84882389207
hcfmusp.origem.wosWOS:000323982800001
hcfmusp.publisher.cityNEW YORK
hcfmusp.publisher.countryUSA
hcfmusp.relation.referenceArnett F C, 1995, Int Rev Immunol, V12, P107, DOI 10.3109/08830189509056707
hcfmusp.relation.referenceArnett FC, 1996, ARTHRITIS RHEUM, V39, P1151, DOI 10.1002/art.1780390712
hcfmusp.relation.referenceArnett FC, 2010, ANN RHEUM DIS, V69, P822, DOI 10.1136/ard.2009.111906
hcfmusp.relation.referenceBeretta L, 2012, RHEUMATOLOGY, V51, P52, DOI 10.1093/rheumatology/ker335
hcfmusp.relation.referenceBernatsky S, 2009, ARTHRIT RHEUM-ARTHR, V61, P400, DOI 10.1002/art.24339
hcfmusp.relation.referenceBRIGGS D, 1993, ARTHRITIS RHEUM, V36, P943, DOI 10.1002/art.1780360711
hcfmusp.relation.referenceChifflot H, 2008, SEMIN ARTHRITIS RHEU, V37, P223, DOI 10.1016/j.semarthrit.2007.05.003
hcfmusp.relation.referenceFanning GC, 1998, BRIT J RHEUMATOL, V37, P201
hcfmusp.relation.referenceFrezza D, 2007, ANN RHEUM DIS, V66, P1210, DOI 10.1136/ard.2006.066597
hcfmusp.relation.referenceGilchrist FC, 2001, GENES IMMUN, V2, P76, DOI 10.1038/sj.gene.6363734
hcfmusp.relation.referenceGladman DD, 2005, J RHEUMATOL, V32, P1481
hcfmusp.relation.referenceHARRISON NK, 1991, AM REV RESPIR DIS, V144, P706
hcfmusp.relation.referenceKarp D. R., 2009, HUM MOL GENET, V19, P707
hcfmusp.relation.referenceKUWANA M, 1995, ANN RHEUM DIS, V54, P983, DOI 10.1136/ard.54.12.983
hcfmusp.relation.referenceKUWANA M, 1993, J CLIN INVEST, V92, P1296, DOI 10.1172/JCI116703
hcfmusp.relation.referenceLambert NC, 2000, ARTHRITIS RHEUM, V43, P2005, DOI 10.1002/1529-0131(200009)43:9<2005::AID-ANR11>3.0.CO;2-#
hcfmusp.relation.referenceLANGEVITZ P, 1992, BRIT J RHEUMATOL, V31, P609
hcfmusp.relation.referenceLenna S, 2010, J IMMUNOL, V184, P4654, DOI 10.4049/jimmunol.0903188
hcfmusp.relation.referenceLEROY EC, 1988, J RHEUMATOL, V15, P202
hcfmusp.relation.referenceLoubiere LS, 2005, RHEUMATOLOGY, V44, P318, DOI 10.1093/rheumatology/keh489
hcfmusp.relation.referenceMARGUERIE C, 1992, MEDICINE, V71, P327, DOI 10.1097/00005792-199211000-00001
hcfmusp.relation.referenceMOREL PA, 1994, HUM IMMUNOL, V40, P101, DOI 10.1016/0198-8859(94)90054-X
hcfmusp.relation.referencePoormoghim H, 2000, ARTHRITIS RHEUM, V43, P444, DOI 10.1002/1529-0131(200002)43:2<444::AID-ANR27>3.0.CO;2-G
hcfmusp.relation.referenceRadstake TRDJ, 2010, NAT GENET, V42, P426, DOI 10.1038/ng.565
hcfmusp.relation.referenceRamirez Allan, 2004, Treat Respir Med, V3, P339, DOI 10.2165/00151829-200403060-00002
hcfmusp.relation.referenceREVEILLE JD, 1992, J CLIN INVEST, V89, P1208, DOI 10.1172/JCI115704
hcfmusp.relation.referenceReveille JD, 2001, SEMIN ARTHRITIS RHEU, V30, P332, DOI 10.1053/sarh.2001.20268
hcfmusp.relation.referenceREVEILLE JD, 1992, J CLIN INVEST, V90, P973, DOI 10.1172/JCI115974
hcfmusp.relation.referenceSantaniello A, 2006, TISSUE ANTIGENS, V68, P239, DOI 10.1111/j.1399-0039.2006.00657.x
hcfmusp.relation.referenceSimeon CP, 2009, J RHEUMATOL, V36, P2733, DOI [10.3899/jrheum.090377, 10.3899/jrheum090377]
hcfmusp.relation.referenceSteen VD, 2007, ANN RHEUM DIS, V66, P940, DOI 10.1136/ard.2006.066068
hcfmusp.relation.referenceTan FK, 1999, TISSUE ANTIGENS, V53, P74, DOI 10.1034/j.1399-0039.1999.530108.x
hcfmusp.relation.referenceWHYTE J, 1994, J AUTOIMMUN, V7, P509, DOI 10.1006/jaut.1994.1037
hcfmusp.relation.referenceZhou XD, 2009, ARTHRITIS RHEUM, V60, P3807, DOI 10.1002/art.24982
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