High 18F-FDG uptake in PMAH correlated with normal expression of Glut1, HK1, HK2, and HK3

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorCAVALCANTE, Isadora Pontes
dc.contributor.authorZERBINI, Maria Claudia Nogueira
dc.contributor.authorALENCAR, Guilherme Asmar
dc.contributor.authorMARIANI, Beatriz de Paula
dc.contributor.authorBUCHPIGUEL, Carlos Alberto
dc.contributor.authorALMEIDA, Madson Queiroz
dc.contributor.authorMENDONCA, Berenice Bilharinho
dc.contributor.authorFRAGOSO, Maria Candida Barisson Villares
dc.date.accessioned2016-07-04T13:58:29Z
dc.date.available2016-07-04T13:58:29Z
dc.date.issued2016
dc.description.abstractBackground Primary macronodular adrenal hyperplasia (PMAH) is a rare cause of Cushing's syndrome, characterized by functioning adrenal macronodules and variable cortisol production. Recently, we demonstrated a high 18F-FDG uptake in PMAH, an unexpected finding for a benign disorder. Purpose To investigate whether there is a correlation between 18F-FDG high uptake and the expression levels of the glycolytic pathway components GLUT1, HK1, HK2, and HK3 in PMAH. Material and Methods We selected 12 patients undergoing surgery for PMAH who had preoperatively undergone 18F-FDG PET/CT. mRNA and protein expression of the selected genes were evaluated in the adrenal nodules from patients who underwent surgery through quantitative RT-PCR and by immunohistochemistry, respectively. Results SUVmax in PMAH was in the range of 3.3-8.9 and the adrenal size was in the range of 3.5-15cm. A strong correlation between 18F-FDG uptake and largest adrenal diameter was observed in patients with PMAH. However, no correlation between 18F-FDG uptake and GLUT1, HK1, HK2, HK3 mRNA, and protein expression was observed. Conclusion High 18F-FDG uptake is observed in the majority of PMAH cases. However, 18F-FDG uptake in PMAH is independent of the expression levels of GLUT1, HK1, HK2, and HK3. Further investigation is required to elucidate the molecular mechanisms underlying increased 18F-FDG uptake in PMAH.
dc.description.indexMEDLINE
dc.description.sponsorshipBrazilian fostering agency Coordination for the Improvement of Higher Education Personnel (CAPES)
dc.description.sponsorshipSao Paulo Research Foundation (FAPESP) [2010/12702-1]
dc.identifier.citationACTA RADIOLOGICA, v.57, n.3, p.370-377, 2016
dc.identifier.doi10.1177/0284185115575195
dc.identifier.eissn1600-0455
dc.identifier.issn0284-1851
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/13977
dc.language.isoeng
dc.publisherSAGE PUBLICATIONS LTD
dc.relation.ispartofActa Radiologica
dc.rightsrestrictedAccess
dc.rights.holderCopyright SAGE PUBLICATIONS LTD
dc.subjectPrimary macronodular adrenal hyperplasia
dc.subject18F-FDG
dc.subjectPET
dc.subjectadrenal
dc.subjectadults
dc.subjecthyperplasia
dc.subjectmonoclonal antibodies
dc.subjectCushing's syndrome
dc.subject.otherpositron-emission-tomography
dc.subject.otherfdg uptake
dc.subject.othercushings-syndrome
dc.subject.otheradrenal-hyperplasia
dc.subject.otherf-18-fdg uptake
dc.subject.otherhexokinase-ii
dc.subject.othercancer
dc.subject.otherproliferation
dc.subject.othercarcinoma
dc.subject.othermasses
dc.subject.wosRadiology, Nuclear Medicine & Medical Imaging
dc.titleHigh 18F-FDG uptake in PMAH correlated with normal expression of Glut1, HK1, HK2, and HK3
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalCAVALCANTE, Isadora Pontes:Univ Sao Paulo, Fac Med, Unidade Suprarrenal,Hosp Clin, Disciplina Endocrinol & Metabol,Lab Hormonios & G, Sao Paulo, Brazil
hcfmusp.author.externalALENCAR, Guilherme Asmar:Univ Sao Paulo, Fac Med, Unidade Suprarrenal,Hosp Clin, Disciplina Endocrinol & Metabol,Lab Hormonios & G, Sao Paulo, Brazil
hcfmusp.citation.scopus9
hcfmusp.contributor.author-fmusphcMARIA CLAUDIA NOGUEIRA ZERBINI
hcfmusp.contributor.author-fmusphcBEATRIZ MARINHO DE PAULA MARIANI
hcfmusp.contributor.author-fmusphcCARLOS ALBERTO BUCHPIGUEL
hcfmusp.contributor.author-fmusphcMADSON QUEIROZ DE ALMEIDA
hcfmusp.contributor.author-fmusphcBERENICE BILHARINHO DE MENDONCA
hcfmusp.contributor.author-fmusphcMARIA CANDIDA BARISSON VILLARES FRAGOSO
hcfmusp.description.beginpage370
hcfmusp.description.endpage377
hcfmusp.description.issue3
hcfmusp.description.volume57
hcfmusp.origemWOS
hcfmusp.origem.pubmed25766729
hcfmusp.origem.scopus2-s2.0-84961704506
hcfmusp.origem.wosWOS:000370684600019
hcfmusp.publisher.cityLONDON
hcfmusp.publisher.countryENGLAND
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hcfmusp.scopus.lastupdate2024-04-12
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