Pulmonary Surfactant in Respiratory Syncytial Virus Bronchiolitis: The Role in Pathogenesis and Clinical Implications

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorBARREIRA, Eliane Roseli
dc.contributor.authorPRECIOSO, Alexander Roberto
dc.contributor.authorBOUSSO, Albert
dc.date.accessioned2017-11-27T16:39:40Z
dc.date.available2017-11-27T16:39:40Z
dc.date.issued2011
dc.description.abstractRespiratory syncytial virus (RSV) bronchiolitis is the leading cause of lower respiratory tract infection, and the most frequent reason for hospitalization among infants throughout the world. In addition to the acute consequences of the disease, RSV bronchiolitis in early childhood is related to further development of recurrent wheezing and asthma. Despite the medical and economic burden of the disease, therapeutic options are limited to supportive measures, and mechanical ventilation in severe cases. Growing evidence suggests an important role of changes in pulmonary surfactant content and composition in the pathogenesis of severe RSV bronchiolitis. Besides the well-known importance of pulmonary surfactant in maintenance of pulmonary homeostasis and lung mechanics, the surfactant proteins SP-A and SP-D are essential components of the pulmonary innate immune system. Deficiencies of such proteins, which develop in severe RSV bronchiolitis, may be related to impairment in viral clearance, and exacerbated inflammatory response. A comprehensive understanding of the role of the pulmonary surfactant in the pathogenesis of the disease may help the development of new treatment strategies. We conducted a review of the literature to analyze the evidences of pulmonary surfactant changes in the pathogenesis of severe RSV bronchiolitis, its relation to the inflammatory and immune response, and the possible role of pulmonary surfactant replacement in the treatment of the disease. Pediatr Pulmonol. 2011; 46:415-420. (c) 2010 Wiley-Liss, Inc.
dc.description.indexMEDLINE
dc.identifier.citationPEDIATRIC PULMONOLOGY, v.46, n.5, p.415-420, 2011
dc.identifier.doi10.1002/ppul.21395
dc.identifier.eissn1099-0496
dc.identifier.issn8755-6863
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/23808
dc.language.isoeng
dc.publisherWILEY-BLACKWELL
dc.relation.ispartofPediatric Pulmonology
dc.rightsrestrictedAccess
dc.rights.holderCopyright WILEY-BLACKWELL
dc.subjectbronchiolitis
dc.subjectrespiratory syncytial virus
dc.subjecthuman
dc.subjectpulmonary surfactants
dc.subject.othera-deficient mice
dc.subject.otherprotein-a
dc.subject.otherhigh-risk
dc.subject.otherin-vivo
dc.subject.otherlung collectins
dc.subject.otherinnate immunity
dc.subject.otherinfection
dc.subject.otherinfants
dc.subject.otherchildren
dc.subject.otherdisease
dc.subject.wosPediatrics
dc.subject.wosRespiratory System
dc.titlePulmonary Surfactant in Respiratory Syncytial Virus Bronchiolitis: The Role in Pathogenesis and Clinical Implications
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.citation.scopus20
hcfmusp.contributor.author-fmusphcELIANE ROSELI BARREIRA
hcfmusp.contributor.author-fmusphcALEXANDER ROBERTO PRECIOSO
hcfmusp.contributor.author-fmusphcALBERT BOUSSO
hcfmusp.description.beginpage415
hcfmusp.description.endpage420
hcfmusp.description.issue5
hcfmusp.description.volume46
hcfmusp.origemWOS
hcfmusp.origem.pubmed21194166
hcfmusp.origem.scopus2-s2.0-79954483603
hcfmusp.origem.wosWOS:000289510500001
hcfmusp.publisher.cityHOBOKEN
hcfmusp.publisher.countryUSA
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