The role of neurocognitive functioning, substance use variables and the DSM-5 severity scale in cocaine relapse: A prospective study

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorLIM, Danielle Ruiz
dc.contributor.authorGONCALVES, Priscila Dib
dc.contributor.authorOMETTO, Mariella
dc.contributor.authorMALBERGIER, Andre
dc.contributor.authorAMARAL, Ricardo Abrantes
dc.contributor.authorSANTOS, Bernardo dos
dc.contributor.authorCAVALLET, Mikael
dc.contributor.authorCHAIM-AVANCINI, Tiffany
dc.contributor.authorSERPA, Mauricio Henriques
dc.contributor.authorFERREIRA, Luiz Roberto Kobuti
dc.contributor.authorDURAN, Fabio Luis de Souza
dc.contributor.authorZANETTI, Marcus Vinicius
dc.contributor.authorNICASTR, Sergio
dc.contributor.authorBUSATTO, Geraldo Filho
dc.contributor.authorANDRAD, Arthur Guerra
dc.contributor.authorCUNH, Paulo Jannuzzi
dc.date.accessioned2019-05-30T13:38:26Z
dc.date.available2019-05-30T13:38:26Z
dc.date.issued2019
dc.description.abstractBackground: The severity of substance use disorder (SUD) is currently defined by the sum of DSM-5 criteria. However, little is known about the validity of this framework or the role of additional severity indicators in relapse prediction. This study aimed to investigate the relationship between DSM-5 criteria, neurocognitive functioning, substance use variables and cocaine relapse among inpatients with cocaine use disorder (CUD). Methods: 128 adults aged between 18 and 45 years were evaluated; 68 (59 males, 9 females) had CUD and 60 (52 males, 8 females) were healthy controls. For the group with CUD, the use of other substances was not an exclusion criterion. Participants were tested using a battery of neurocognitive tests. Cocaine relapse was evaluated 3 months after discharge. Results: Scores for attention span and working memory were worse in patients compared to controls. Earlier onset and duration of cocaine use were related to poorer inhibitory control and global executive functioning, respectively; recent use was related to worse performance in inhibitory control, attention span and working memory. More DSM-5 criteria at baseline were significantly associated with relapse. Conclusions: Recent cocaine use was the most predictive variable for neurocognitive impairments, while DSM-5 criteria predicted cocaine relapse at three months post treatment. The integration of neurocognitive measures, DSM-5 criteria and cocaine use variables in CUD diagnosis could improve severity differentiation. Longitudinal studies using additional biomarkers are needed to disentangle the different roles of severity indicators in relapse prediction and to achieve more individualized and effective treatment strategies for these patients.eng
dc.description.indexMEDLINEeng
dc.description.sponsorshipNational Council for Scientific and Technological Development - CNPq [402721/2010-1]
dc.description.sponsorshipSao Paulo Research Foundation - FAPESP [2010/01272-6, 2010/15604-0, 2010/15786-1]
dc.description.sponsorshipCAPES Program of Excellency (CAPES-PROEX)
dc.identifier.citationDRUG AND ALCOHOL DEPENDENCE, v.197, p.255-261, 2019
dc.identifier.doi10.1016/j.drugalcdep.2019.01.013
dc.identifier.eissn1879-0046
dc.identifier.issn0376-8716
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/31807
dc.language.isoeng
dc.publisherELSEVIER IRELAND LTDeng
dc.relation.ispartofDrug and Alcohol Dependence
dc.rightsrestrictedAccesseng
dc.rights.holderCopyright ELSEVIER IRELAND LTDeng
dc.subjectAddictioneng
dc.subjectAssessmenteng
dc.subjectCocaineeng
dc.subjectNeurocognitioneng
dc.subjectRelapseeng
dc.subjectSeverityeng
dc.subject.otherexecutive functionseng
dc.subject.otheruse disorderseng
dc.subject.othergray-mattereng
dc.subject.otherdrug-useeng
dc.subject.othercognitive impairmenteng
dc.subject.othertreatment retentioneng
dc.subject.otherdependent patientseng
dc.subject.otherself-regulationeng
dc.subject.otheralcoholeng
dc.subject.otheronseteng
dc.subject.wosSubstance Abuseeng
dc.subject.wosPsychiatryeng
dc.titleThe role of neurocognitive functioning, substance use variables and the DSM-5 severity scale in cocaine relapse: A prospective studyeng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.author.externalSANTOS, Bernardo dos:Univ Sao Paulo, Fac Med, Hosp Clin HCFMUSP, Escola Enfermagem, Av Dr Eneas Carvalho Aguiar 419, BR-05403000 Sao Paulo, SP, Brazil
hcfmusp.author.externalCAVALLET, Mikael:Univ Sao Paulo, Fac Med, Hosp Clin HCFMUSP, Lab Neuroimagem Psiquiatria 21,Inst Psiquiatria I, R Dr Ovidio Pires Campos 785, BR-01060970 Sao Paulo, SP, Brazil
hcfmusp.citation.scopus13
hcfmusp.contributor.author-fmusphcDANIELLE RUIZ DE LIMA
hcfmusp.contributor.author-fmusphcPRISCILA DIB GONCALVES
hcfmusp.contributor.author-fmusphcMARIELLA OMETTO SCARPARO
hcfmusp.contributor.author-fmusphcANDRE MALBERGIER
hcfmusp.contributor.author-fmusphcRICARDO ABRANTES DO AMARAL
hcfmusp.contributor.author-fmusphcTIFFANY MOUKBEL CHAIM AVANCINI
hcfmusp.contributor.author-fmusphcMAURICIO HENRIQUES SERPA
hcfmusp.contributor.author-fmusphcLUIZ ROBERTO KOBUTI FERREIRA
hcfmusp.contributor.author-fmusphcFABIO LUIS DE SOUZA DURAN
hcfmusp.contributor.author-fmusphcMARCUS VINICIUS ZANETTI
hcfmusp.contributor.author-fmusphcSERGIO NICASTRI
hcfmusp.contributor.author-fmusphcGERALDO BUSATTO FILHO
hcfmusp.contributor.author-fmusphcARTHUR GUERRA DE ANDRADE
hcfmusp.contributor.author-fmusphcPAULO JANNUZZI CUNHA
hcfmusp.description.beginpage255
hcfmusp.description.endpage261
hcfmusp.description.volume197
hcfmusp.origemWOS
hcfmusp.origem.pubmed30875646
hcfmusp.origem.scopus2-s2.0-85062689648
hcfmusp.origem.wosWOS:000464479000036
hcfmusp.publisher.cityCLAREeng
hcfmusp.publisher.countryIRELANDeng
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