Relationship between endothelial nitric oxide synthase (eNOS) and natural history of intracranial aneurysms: meta-analysis

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorPASCHOAL, Eric Homero Albuquerque
dc.contributor.authorYAMAKI, Vitor Nagai
dc.contributor.authorTEIXEIRA, Renan Kleber Costa
dc.contributor.authorPASCHOAL JUNIOR, Fernando Mendes
dc.contributor.authorJONG-A-LIEM, Glaucia Suzanna
dc.contributor.authorTEIXEIRA, Manoel Jacobsen
dc.contributor.authorYAMADA, Elizabeth Sumi
dc.contributor.authorRIBEIRO-DOS-SANTOS, Andrea
dc.contributor.authorBOR-SENG-SHU, Edson
dc.date.accessioned2018-02-02T16:55:36Z
dc.date.available2018-02-02T16:55:36Z
dc.date.issued2018
dc.description.abstractThe aneurysmal subarachnoid hemorrhage is a major public health problem described as a sudden drastic event with no warning symptoms and high morbidity and mortality rates. The role of the endothelial isoform of nitric oxide synthase gene polymorphism in intracranial aneurysms (IAs) is still a matter of controversy with divergent findings among European, American, and Asian populations. Our study purposed to test the association between intracranial aneurysms formation and nitric oxide gene polymorphisms through a systematic review and meta-analysis. Systematic search on Medline, Lilacs, and EMBASE was performed. The primary search resulted in 139 papers, out of which 9 met our inclusion criteria after a full text analysis. The dominant T786C model found a significant association with IA (OR 1.22, 95 % CI 1.04-1.44, p = 0.01), so did studies of the recessive T786C model (OR 0.37, 95 % CI 0.30-0.45, p < 0.0001) but with opposite effect. Our findings support the presence of the T786C polymorphism as a predictor for the development of intracranial aneurysm in the cerebral vascular system. More studies are necessary in order to elucidate the pathways of the endothelial nitric oxide synthase (eNOS) in cerebrovascular diseases and in defining how different allelic combinations of the eNOS gene single-nucleotide polymorphism (SNP) could favor this pathological process.
dc.description.indexMEDLINE
dc.identifier.citationNEUROSURGICAL REVIEW, v.41, n.1, p.87-94, 2018
dc.identifier.doi10.1007/s10143-016-0761-4
dc.identifier.eissn1437-2320
dc.identifier.issn0344-5607
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/24923
dc.language.isoeng
dc.publisherSPRINGER
dc.relation.ispartofNeurosurgical Review
dc.rightsrestrictedAccess
dc.rights.holderCopyright SPRINGER
dc.subjectEndothelial nitric oxide synthase
dc.subjectGenetic polymorphisms
dc.subjectIntracranial aneurysms
dc.subjectMeta-analysis
dc.subjectSubarachnoid hemorrhage
dc.subject.othersingle-nucleotide polymorphism
dc.subject.othersubarachnoid hemorrhage
dc.subject.othercerebral vasospasm
dc.subject.othergene polymorphisms
dc.subject.otheraortic-aneurysm
dc.subject.otherrisk-factor
dc.subject.otherdisease
dc.subject.otheratherosclerosis
dc.subject.otherrupture
dc.subject.othersize
dc.subject.wosClinical Neurology
dc.subject.wosSurgery
dc.titleRelationship between endothelial nitric oxide synthase (eNOS) and natural history of intracranial aneurysms: meta-analysis
dc.typearticle
dc.type.categoryreview
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalYAMAKI, Vitor Nagai:Univ Estado Para, Dept Neurosurg, Belem, Para, Brazil
hcfmusp.author.externalTEIXEIRA, Renan Kleber Costa:Univ Estado Para, Dept Surg, Belem, Para, Brazil
hcfmusp.author.externalJONG-A-LIEM, Glaucia Suzanna:Univ Estado Para, Dept Neurosurg, Belem, Para, Brazil
hcfmusp.author.externalYAMADA, Elizabeth Sumi:Univ Fed Para, Dept Genet, Belem, Para, Brazil
hcfmusp.author.externalRIBEIRO-DOS-SANTOS, Andrea:Univ Fed Para, Dept Genet, Belem, Para, Brazil
hcfmusp.citation.scopus18
hcfmusp.contributor.author-fmusphcERIC HOMERO ALBUQUERQUE PASCHOAL
hcfmusp.contributor.author-fmusphcFERNANDO MENDES PASCHOAL JUNIOR
hcfmusp.contributor.author-fmusphcMANOEL JACOBSEN TEIXEIRA
hcfmusp.contributor.author-fmusphcEDSON BOR-SENG SHU
hcfmusp.description.beginpage87
hcfmusp.description.endpage94
hcfmusp.description.issue1
hcfmusp.description.volume41
hcfmusp.origemWOS
hcfmusp.origem.pubmed27339197
hcfmusp.origem.scopus2-s2.0-84976295071
hcfmusp.origem.wosWOS:000419166400009
hcfmusp.publisher.cityNEW YORK
hcfmusp.publisher.countryUSA
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