Reference values for high-density lipoprotein particle size and volume by dynamic light scattering in a Brazilian population sample and their relationships with metabolic parameters

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art_ALEXANDRE_Reference_values_for_highdensity_lipoprotein_particle_size_and_2015.PDF (983.07 KB)
Citações na Scopus
4
Tipo de produção
article
Data de publicação
2015
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
ELSEVIER SCIENCE BV
Autores
ALEXANDRE, F.
ZAGO, V. H. S.
PANZOLDO, N. B.
PARRA, E. S.
SCHERRER, D. Z.
VENDRAME, F.
GOMES, E. I. L.
MARCATO, P. D.
Citação
CLINICA CHIMICA ACTA, v.442, p.63-72, 2015
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Background: Current data indicate that the size of high-density lipoprotein (HDL) may be considered an important marker for cardiovascular disease risk. We established reference values of mean HDL size and volume in an asymptomatic representative Brazilian population sample (n = 590) and their associations with metabolic parameters by gender. Methods: Size and volume were determined in HDL isolated from plasma by polyethyleneglycol precipitation of apoB-containing lipoproteins and measured using the dynamic light scattering (DLS) technique. Results: Although the gender and age distributions agreed with other studies, the mean HDL size reference value was slightly lower than in some other populations. Both HDL size and volume were influenced by gender and varied according to age. HDL size was associated with age and HDL-C (total population); non- white ethnicity and CETP inversely (females); HDL-C and PLTP mass (males). On the other hand, HDL volume was determined only by HDL-C (total population and in both genders) and by PLTP mass (males). Conclusions: The reference values for mean HDL size and volume using the DLS technique were established in an asymptomatic and representative Brazilian population sample, as well as their related metabolic factors. HDL-C was a major determinant of HDL size and volume, which were differently modulated in females and in males.
Palavras-chave
Dynamic light scattering, HDL size, HDL volume, Reference values, Metabolic parameters
URI
https://observatorio.fm.usp.br/handle/OPI/9679
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MCM
Artigos e Materiais de Revistas Científicas - LIM/10
Artigos e Materiais de Revistas Científicas - ODS/03