New Players in the Same Old Game: Disturbance of Group 2 Innate Lymphoid Cells in HIV-1 and Mycobacterium leprae Coinfected Patients

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorPAPOTTO, Pedro Henrique
dc.contributor.authorMAEDA, Solange
dc.contributor.authorTOMIMORI, Jane
dc.contributor.authorXAVIER, Marilia Brasil
dc.contributor.authorRIZZO, Luiz Vicente
dc.contributor.authorKALLAS, Esper Georges
dc.contributor.authorCARVALHO, Karina Inacio
dc.date.accessioned2015-12-10T16:41:12Z
dc.date.available2015-12-10T16:41:12Z
dc.date.issued2015
dc.description.abstractLeprosy control is achieved through a fine-tuning of T(H)1 and T(H)2 immune response pattern balance. Given the increasing epidemiological overlay of HIV and M. leprae infections, immune response in co-infected patients consists in an important contemporary issue. Here we describe for the first time the innate lymphoid cells compartment in peripheral blood of leprosy and HIV/M. leprae co-infected patients, and show that co-infection increases group 2 innate lymphoid whilst decreasing group 1 innate lymphoid cells frequencies and function.
dc.description.indexMEDLINE
dc.description.sponsorshipUS National Institutes of Health [52731]
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo [2013/15448-7]
dc.identifier.citationPLOS NEGLECTED TROPICAL DISEASES, v.9, n.9, article ID e0004030, 8p, 2015
dc.identifier.doi10.1371/journal.pntd.0004030
dc.identifier.issn1935-2735
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/12310
dc.language.isoeng
dc.publisherPUBLIC LIBRARY SCIENCE
dc.relation.ispartofPlos Neglected Tropical Diseases
dc.rightsopenAccess
dc.rights.holderCopyright PUBLIC LIBRARY SCIENCE
dc.subject.othert-cells
dc.subject.otherleprosy
dc.subject.wosInfectious Diseases
dc.subject.wosParasitology
dc.subject.wosTropical Medicine
dc.titleNew Players in the Same Old Game: Disturbance of Group 2 Innate Lymphoid Cells in HIV-1 and Mycobacterium leprae Coinfected Patients
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalPAPOTTO, Pedro Henrique:Hosp Israelita Albert Einstein, Inst Israelita Ensino & Pesquisa, Sao Paulo, Brazil
hcfmusp.author.externalMAEDA, Solange:Univ Fed Sao Paulo, Dept Dermatol, Sao Paulo, Brazil
hcfmusp.author.externalTOMIMORI, Jane:Univ Fed Sao Paulo, Dept Dermatol, Sao Paulo, Brazil
hcfmusp.author.externalXAVIER, Marilia Brasil:Fed Univ Para, Dept Dermatol, BR-66059 Belem, Para, Brazil
hcfmusp.author.externalRIZZO, Luiz Vicente:Hosp Israelita Albert Einstein, Inst Israelita Ensino & Pesquisa, Sao Paulo, Brazil
hcfmusp.author.externalCARVALHO, Karina Inacio:Hosp Israelita Albert Einstein, Inst Israelita Ensino & Pesquisa, Sao Paulo, Brazil
hcfmusp.citation.scopus2
hcfmusp.contributor.author-fmusphcESPER GEORGES KALLAS
hcfmusp.description.articlenumbere0004030
hcfmusp.description.issue9
hcfmusp.description.volume9
hcfmusp.origemWOS
hcfmusp.origem.pubmed26335023
hcfmusp.origem.scopus2-s2.0-84943153734
hcfmusp.origem.wosWOS:000363031200023
hcfmusp.publisher.citySAN FRANCISCO
hcfmusp.publisher.countryUSA
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hcfmusp.scopus.lastupdate2024-05-10
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Artigos e Materiais de Revistas Científicas - FM/MCM
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/60
Artigos e Materiais de Revistas Científicas - ODS/03