Heat shock protein production and immunity and altered fetal development in diabetic pregnant rats

Imagem de Miniatura
Arquivos
art_LINHARES_Heat_shock_protein_production_and_immunity_and_altered_2013.PDF (207.16 KB)
Citações na Scopus
14
Tipo de produção
article
Data de publicação
2013
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
SPRINGER
Autores
SAITO, Felipe Hiroshi
DAMASCENO, Debora Cristina
DALLAQUA, Bruna
RUDGE, Marilza Vieira Cunha
CALDERON, Iracema De Mattos Paranhos
WITKIN, Steven S.
Citação
CELL STRESS & CHAPERONES, v.18, n.1, p.25-33, 2013
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
We evaluated associations between the concentrations of heat shock proteins (hsp60 and hsp70) and their respective antibodies, alterations in maternal reproductive performance, and fetal malformations in pregnant rats with hyperglycemia. Mild diabetes (MD) or severe diabetes (SD) was induced in Sprague-Dawley rats prior to mating; non-treated non-diabetic rats (ND) served as controls. On day 21 of pregnancy, maternal blood was analyzed for hsp60 and hsp70 and their antibodies; and fetuses were weighed and analyzed for congenital malformations. Hsp and anti-hsp levels were correlated with blood glucose levels during gestation. There was a positive correlation between hsp60 and hsp70 levels and the total number of malformations (R = 0.5908, P = 0.0024; R = 0.4877, P = 0.0134, respectively) and the number of malformations per fetus (R = 0.6103, P = 0.0015; R = 0.4875, P = 0.0134, respectively). The anti-hsp60 IgG concentration was correlated with the number of malformations per fetus (R = 0.3887, P = 0.0451) and the anti-hsp70 IgG level correlated with the total number of malformations (R = 0.3999, P = 0.0387). Moreover, both hsp and anti-hsp antibodies showed negative correlations with fetal weight. The results suggest that there is a relationship between hsp60 and hsp70 levels and their respective antibodies and alterations in maternal reproductive performance and impaired fetal development and growth in pregnancies associated with diabetes.
Palavras-chave
Diabetes, Pregnancy, Malformation, Heat shock protein
URI
https://observatorio.fm.usp.br/handle/OPI/2318
Referências
  1. Akerfelt M, 2007, ANN NY ACAD SCI, V1113, P15, DOI 10.1196/annals.1391.005
  2. ALIVERTI V, 1979, TERATOLOGY, V20, P237, DOI 10.1002/tera.1420200208
  3. Alsat E, 1995, REPROD FERT DEVELOP, V7, P1457, DOI 10.1071/RD9951457
  4. American Diabetes Association, 2011, DIABETES CARE S1, V34, pS62, DOI 10.2337/DC11-S062
  5. Anderson Robin L., 1998, Cell Stress and Chaperones, V3, P209, DOI 10.1054/csac.1998.0109
  6. Belhia F, 2010, GYNECOL OBSTET INVES, V70, P299, DOI 10.1159/000314021
  7. Bruce CR, 2003, DIABETES, V52, P2338, DOI 10.2337/diabetes.52.9.2338
  8. Calabrese V, 2007, CELL STRESS CHAPERON, V12, P299, DOI 10.1379/CSC-270.1
  9. Calderon IMP, 1992, ACTA CIR BRAS, V7, P142
  10. Caluwaerts S, 2003, J SOC GYNECOL INVEST, V10, P216, DOI 10.1016/S1071-5576(03)00044-3
  11. CHIERI RA, 1969, FERTIL STERIL, V20, P661
  12. Child DF, 2006, CELL STRESS CHAPERON, V11, P101, DOI 10.1379/CSC-130R1.1
  13. Chung J, 2008, P NATL ACAD SCI USA, V105, P1739, DOI 10.1073/pnas.0705799105
  14. Cnattingius S, 1998, NEW ENGL J MED, V338, P147, DOI 10.1056/NEJM199801153380302
  15. Damasceno DC, 2011, DIABETOL METAB SYNDR, V3, DOI 10.1186/1758-5996-3-20
  16. Daskalakis G, 2008, ACTA OBSTET GYN SCAN, V87, P403, DOI 10.1080/00016340801908783
  17. de Souza MDS, 2009, REPROD BIOMED ONLINE, V18, P562
  18. Dienelt A, 2011, STEM CELLS DEV, V20, P465, DOI 10.1089/scd.2010.0205
  19. Dix DJ, 1998, MOL REPROD DEV, V51, P373, DOI 10.1002/(SICI)1098-2795(199812)51:4<373::AID-MRD3>3.0.CO;2-E
  20. Eriksson UJ, 2000, UPSALA J MED SCI, V105, P53
  21. Eriksson UJ, 2009, SEMIN FETAL NEONAT M, V14, P85, DOI 10.1016/j.siny.2008.11.001
  22. Eriksson UJ, 2003, REV ENDOCR METAB DIS, V4, P79, DOI 10.1023/A:1021879504372
  23. Febbraio MA, 2004, CELL STRESS CHAPERON, V9, P390, DOI 10.1379/CSC-24R1.1
  24. GARRIS DR, 1986, ANAT REC, V216, P359, DOI 10.1002/ar.1092160304
  25. Gruden G, 2009, J INTERN MED, V266, P527, DOI 10.1111/j.1365-2796.2009.02129.x
  26. Henderson B, 2012, CELL STRESS CHAPERON, V17, P303, DOI 10.1007/s12192-011-0318-y
  27. Hunter-Lavin C, 2004, CELL STRESS CHAPERON, V9, P344, DOI 10.1379/CSC-28R.1
  28. Iessi IL, 2010, DIABETOL METAB SYNDR, V2, DOI 10.1186/1758-5996-2-37
  29. Jawerbaum A, 2006, CURR MED CHEM, V13, P2127, DOI 10.2174/092986706777935302
  30. Jawerbaum A, 2010, ENDOCR REV, V31, P680, DOI 10.1210/er.2009-0038
  31. Kavanagh K, 2009, CELL STRESS CHAPERON, V14, P291, DOI 10.1007/s12192-008-0084-7
  32. Kirchick HJ, 1978, ENDOCRINOLOGY, V109, P316
  33. Luft JC, 1999, CELL STRESS CHAPERON, V4, P162, DOI 10.1379/1466-1268(1999)004<0162:HEAFDE>2.3.CO;2
  34. Matwee C, 2001, MOL HUM REPROD, V7, P829, DOI 10.1093/molehr/7.9.829
  35. MORANGE M, 1984, MOL CELL BIOL, V4, P730
  36. Morgan SC, 2008, BIRTH DEFECTS RES A, V82, P453, DOI 10.1002/bdra.20457
  37. Neuer A, 2000, HUM REPROD UPDATE, V6, P149, DOI 10.1093/humupd/6.2.149
  38. Neuer A, 1998, HUM REPROD, V13, P987, DOI 10.1093/humrep/13.4.987
  39. Oglesbee MJ, 2005, CLIN BIOCHEM, V38, P900, DOI 10.1016/j.clinbiochem.2005.05.011
  40. OH W, 1991, PEDIATR RES, V29, P606, DOI 10.1203/00006450-199106010-00016
  41. Ornoy A, 2007, REPROD TOXICOL, V24, P31, DOI 10.1016/j.reprotox.2007.04.004
  42. Portha B, 1974, DIABETES, V23, P888
  43. Reece EA, 2005, AM J OBSTET GYNECOL, V192, P967, DOI 10.1016/j.ajog.2004.10.592
  44. Rudge MVC, 2007, BRAZ J MED BIOL RES, V40, P1095, DOI 10.1590/S0100-879X2006005000132
  45. Saito FH, 2010, DIABETOL METAB SYNDR, V2, DOI 10.1186/1758-5996-2-26
  46. Schaefer-Graf UM, 2000, AM J OBSTET GYNECOL, V182, P313, DOI 10.1016/S0002-9378(00)70217-1
  47. Siman CM, 2000, TERATOLOGY, V61, P355, DOI 10.1002/(SICI)1096-9926(200005)61:5<355::AID-TERA7>3.0.CO;2-W
  48. Sinzato YK, 2009, REV ASSOC MED BRAS, V55, P384, DOI 10.1590/S0104-42302009000400010
  49. Sinzato YK, 2011, BRAZ J MED BIOL RES, V44, P206, DOI 10.1590/S0100-879X2011000300005
  50. Sivan E, 1997, TERATOLOGY, V56, P343, DOI 10.1002/(SICI)1096-9926(199712)56:6<343::AID-TERA1>3.0.CO;2-X
  51. Soulimane-Mokhtari NA, 2005, CLIN SCI, V109, P287, DOI 10.1042/CS20050028
  52. STAPLES RE, 1964, STAIN TECHNOL, V39, P61
  53. Sugimura Y, 2009, DIABETOLOGIA, V52, P962, DOI 10.1007/s00125-009-1312-0
  54. Tan H, 2007, CELL STRESS CHAPERON, V12, P230, DOI 10.1379/CSC-266.1
  55. Toscano C. M., 2004, Ciência & Saúde Coletiva, V9, P885, DOI 10.1590/S1413-81232004000400010
  56. TSUJI K, 1988, METABOLISM, V37, P1040, DOI 10.1016/0026-0495(88)90064-9
  57. Vambergue Anne, 2011, World J Diabetes, V2, P196, DOI 10.4239/wjd.v2.i11.196
  58. Volpato GT, 2008, J ETHNOPHARMACOL, V116, P131, DOI 10.1016/j.jep.2007.11.013
  59. VOMACHKA MS, 1982, P SOC EXP BIOL MED, V171, P207
  60. Wilson JC, 1965, TERATOLOGY PRINCIPLE
  61. WITTIG S, 1983, DEV BIOL, V96, P507, DOI 10.1016/0012-1606(83)90187-2
  62. Yabunaka N, 1995, DIABETES RES CLIN PR, V30, P143, DOI 10.1016/0168-8227(95)01151-X
  63. Zhong X, 2011, CELL STRESS CHAPERON, V15, P335
  64. Zhu Y, 2012, TOXICOL IND HEALTH, DOI [10.1177/0748233712446720, DOI 10.1177/0748233712446720]

Coleções
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/58
Artigos e Materiais de Revistas Científicas - ODS/03