Understanding the gut microbiota in cancer cachexia

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art_ROCHA_Understanding_the_gut_microbiota_in_cancer_cachexia_2023.PDF (776.57 KB)
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0
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article
Data de publicação
2023
DOI
Scopus
Web of Science
PubMed
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Editora
LIPPINCOTT WILLIAMS & WILKINS
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CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE, v.26, n.5, p.482-489, 2023
Projetos de Pesquisa
Unidades Organizacionais
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Resumo
Purpose of reviewCachexia is a complex, multifactorial syndrome primarily characterized by weight loss, muscle wasting, anorexia, and systemic inflammation. It is prevalent in cancer patients and is associated with a poor prognosis, including lower resistance to intervention toxicity, quality of life, and survival, compared to patients without the syndrome. The gut microbiota and its metabolites have been shown to influence host metabolism and immune response. Our article reviews the current evidence suggesting a role of gut microbiota in the development and progression of cachexia, while discussing the potential mechanisms involved. We also describe promising interventions targeting gut microbiota aiming to improve outcomes related to cachexia.Recent findingsDysbiosis, an imbalance in gut microbiota, has been associated with cancer cachexia through pathways involving muscle wasting, inflammation, and gut barrier dysfunction. Interventions targeting gut microbiota, such as probiotics, prebiotics, synbiotics, and fecal microbiota transplantation, have shown promising results in managing this syndrome in animal models. However, evidence in humans is currently limited.Mechanisms linking gut microbiota and cancer cachexia need to be further explored, and additional human research is necessary to evaluate the appropriate dosages, safety, and long-term outcomes of prebiotic and probiotic use in microbiota management for cancer cachexia.
Palavras-chave
cancer cachexia, gut microbiota, inflammation
URI
https://observatorio.fm.usp.br/handle/OPI/56093
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MGT
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/35
Artigos e Materiais de Revistas Científicas - ODS/03