GLUT4 translocation is not impaired after acute exercise in skeletal muscle of women with obesity and polycystic ovary syndrome

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art_DANTAS_GLUT4_translocation_is_not_impaired_after_acute_exercise_2015.PDF (470.2 KB)
Citações na Scopus
15
Tipo de produção
article
Data de publicação
2015
DOI
Scopus
Web of Science
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ISSN da Revista
Título do Volume
Editora
WILEY-BLACKWELL
Autores
DANTAS, Wagner Silva
ZAMBELLI, Vanessa Olzon
NEVES, Willian Das
BARCELLOS, Cristiano Roberto Grimaldi
ROCHA, Michele Patrocinio
PEREIRA, Renato Tavares Dos Santos
Citação
OBESITY, v.23, n.11, p.2207-2215, 2015
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
ObjectiveThe aim of this study was to examine the effects of acute exercise on insulin signaling in skeletal muscle of women with polycystic ovary syndrome (PCOS) and controls (CTRL). MethodsFifteen women with obesity and PCOS and 12 body mass index-matched CTRL participated in this study. Subjects performed a 40-min single bout of exercise. Muscle biopsies were performed before and 60 min after exercise. Selected proteins were assessed by Western blotting. ResultsCTRL, but not PCOS, showed a significant increase in PI3-k p85 and AS160 Thr 642 after a single bout of exercise (P=0.018 and P=0.018, respectively). Only PCOS showed an increase in Akt Thr 308 and AMPK phosphorylation after exercise (P=0.018 and P=0.018, respectively). Total GLUT4 expression was comparable between groups (P>0.05). GLUT4 translocation tended to be significantly higher in both groups after exercise (PCOS: P=0.093; CTRL: P=0.091), with no significant difference between them (P>0.05). ConclusionsA single bout of exercise elicited similar GLUT4 translocation in skeletal muscle of PCOS and CTRL, despite a slightly differential pattern of protein phosphorylation. The absence of impairment in GLUT4 translocation suggests that PCOS patients with obesity and insulin resistance may benefit from exercise training.
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https://observatorio.fm.usp.br/handle/OPI/12620
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MCM
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/17
Artigos e Materiais de Revistas Científicas - ODS/03