16th International Congress on Antiphospholipid Antibodies Task Force Report on Antiphospholipid Syndrome Treatment Trends
dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | |
dc.contributor.author | COHEN, Hannah | |
dc.contributor.author | CUADRADO, Maria J. | |
dc.contributor.author | ERKAN, Doruk | |
dc.contributor.author | DUARTE-GARCIA, Ali | |
dc.contributor.author | ISENBERG, David A. | |
dc.contributor.author | KNIGHT, Jason S. | |
dc.contributor.author | ORTEL, Thomas L. | |
dc.contributor.author | RAHMAN, Anisur | |
dc.contributor.author | SALMON, Jane E. | |
dc.contributor.author | TEKTONIDOU, Maria G. | |
dc.contributor.author | WILLIAMS, David J. | |
dc.contributor.author | WILLIS, Rohan | |
dc.contributor.author | WOLLER, Scott C. | |
dc.contributor.author | ANDRADE, Danieli | |
dc.date.accessioned | 2021-06-17T13:57:53Z | |
dc.date.available | 2021-06-17T13:57:53Z | |
dc.date.issued | 2020 | |
dc.description.abstract | Antiphospholipid syndrome (APS), an acquired autoimmune thrombophilia, is characterised by thrombosis and/or pregnancy morbidity in association with persistent antiphospholipid antibodies. The 16th International Congress on Antiphospholipid Antibodies Task Force on APS Treatment Trends reviewed the current status with regard to existing and novel treatment trends for APS, which is the focus of this Task Force report. The report addresses current treatments and developments since the last report, on the use of direct oral anticoagulants in patients with APS, antiplatelet agents, adjunctive therapies (hydroxychloroquine, statins and vitamin D), targeted treatment including rituximab, belimumab, and anti-TNF agents, complement inhibition and drugs based on peptides of beta-2-glycoprotein I. In addition, the report summarises potential new players, including coenzyme Q10, adenosine receptor agonists and adenosine potentiation. In each case, the report provides recommendations for clinicians, based on the current state of the art, and suggests a clinical research agenda. The initiation and development of appropriate clinical studies requires a focus on devising suitable outcome measures, including a disease activity index, an optimal damage index, and a specific quality of life index. | eng |
dc.description.index | MEDLINE | eng |
dc.description.sponsorship | Medical Research CouncilUK Research & Innovation (UKRI)Medical Research Council UK (MRC)European Commission [MR/P017371/1] Funding Source: Medline | |
dc.identifier.citation | LUPUS, v.29, n.12, p.1571-1593, 2020 | |
dc.identifier.doi | 10.1177/0961203320950461 | |
dc.identifier.eissn | 1477-0962 | |
dc.identifier.issn | 0961-2033 | |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/41009 | |
dc.language.iso | eng | |
dc.publisher | SAGE PUBLICATIONS LTD | eng |
dc.relation.ispartof | Lupus | |
dc.rights | openAccess | eng |
dc.rights.holder | Copyright SAGE PUBLICATIONS LTD | eng |
dc.subject | Antiphospholipid syndrome | eng |
dc.subject | direct oral anticoagulants | eng |
dc.subject | biologics | eng |
dc.subject | complement inhibition | eng |
dc.subject | anti-β | eng |
dc.subject | 2-glycoprotein I peptides | eng |
dc.subject | potential new players | eng |
dc.subject.other | systemic-lupus-erythematosus | eng |
dc.subject.other | neutrophil extracellular traps | eng |
dc.subject.other | primary thrombosis prophylaxis | eng |
dc.subject.other | acute venous thromboembolism | eng |
dc.subject.other | direct oral anticoagulants | eng |
dc.subject.other | vitamin-d deficiency | eng |
dc.subject.other | tissue factor | eng |
dc.subject.other | complement activation | eng |
dc.subject.other | pregnancy loss | eng |
dc.subject.other | primary prevention | eng |
dc.subject.wos | Rheumatology | eng |
dc.title | 16th International Congress on Antiphospholipid Antibodies Task Force Report on Antiphospholipid Syndrome Treatment Trends | eng |
dc.type | article | eng |
dc.type.category | original article | eng |
dc.type.version | publishedVersion | eng |
dspace.entity.type | Publication | |
hcfmusp.affiliation.country | Grécia | |
hcfmusp.affiliation.country | Estados Unidos | |
hcfmusp.affiliation.country | Espanha | |
hcfmusp.affiliation.country | Inglaterra | |
hcfmusp.affiliation.countryiso | gb | |
hcfmusp.affiliation.countryiso | es | |
hcfmusp.affiliation.countryiso | us | |
hcfmusp.affiliation.countryiso | gr | |
hcfmusp.author.external | COHEN, Hannah:UCL, Haemostasis Res Unit, Dept Haematol, 1st Floor,51 Chenies Mews, London WC1E 6HX, England; Univ Coll London Hosp NHS Fdn Trust, London, England | |
hcfmusp.author.external | CUADRADO, Maria J.:Clin Univ Navarra, Rheumatol Dept, Madrid, Spain | |
hcfmusp.author.external | ERKAN, Doruk:Weill Cornell Med, Barbara Volcker Ctr Women & Rheumat Dis, Hosp Special Surg, New York, NY USA | |
hcfmusp.author.external | DUARTE-GARCIA, Ali:Mayo Clin, Div Rheumatol, Dept Internal Med, Rochester, MN USA; Mayo Clin, Robert D & Patricia E Kern Ctr Sci Hlth Care Deli, Rochester, MN USA | |
hcfmusp.author.external | ISENBERG, David A.:Univ Coll London Hosp NHS Fdn Trust, London, England; UCL, Div Med, Ctr Rheumatol, London, England | |
hcfmusp.author.external | KNIGHT, Jason S.:Univ Michigan, Div Rheumatol, Ann Arbor, MI 48109 USA | |
hcfmusp.author.external | ORTEL, Thomas L.:Duke Univ, Med Ctr, Dept Med, Div Hematol, Durham, NC 27710 USA; Duke Univ, Med Ctr, Dept Pathol, Durham, NC 27710 USA | |
hcfmusp.author.external | RAHMAN, Anisur:UCL, Div Med, Ctr Rheumatol, London, England | |
hcfmusp.author.external | SALMON, Jane E.:Weill Cornell Med, Hosp Special Surg, Div Rheumatol, New York, NY USA | |
hcfmusp.author.external | TEKTONIDOU, Maria G.:Natl & Kapodistrian Univ Athens, Dept Propaedeut Internal Med 1, Athens, Greece | |
hcfmusp.author.external | WILLIAMS, David J.:Univ Coll London Hosp NHS Fdn Trust, London, England; UCL, UCL EGA Inst Womens Hlth, London, England | |
hcfmusp.author.external | WILLIS, Rohan:Univ Texas Med Branch, Antiphospholipid Standardizat Lab, Galveston, TX 77555 USA | |
hcfmusp.author.external | WOLLER, Scott C.:Intermt Med Ctr, Dept Med, Murray, UT USA; Univ Utah, Sch Med, Div Gen Internal Med, Salt Lake City, UT USA | |
hcfmusp.citation.scopus | 74 | |
hcfmusp.contributor.author-fmusphc | DANIELI CASTRO OLIVEIRA DE ANDRADE | |
hcfmusp.description.beginpage | 1571 | |
hcfmusp.description.endpage | 1593 | |
hcfmusp.description.issue | 12 | |
hcfmusp.description.volume | 29 | |
hcfmusp.origem | WOS | |
hcfmusp.origem.pubmed | 33100166 | |
hcfmusp.origem.scopus | 2-s2.0-85094628694 | |
hcfmusp.origem.wos | WOS:000584375600009 | |
hcfmusp.publisher.city | LONDON | eng |
hcfmusp.publisher.country | ENGLAND | eng |
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