Impact of Seasonality on the Prevalence of Dyslipidemia: A Large Population Study
Carregando...
Citações na Scopus
32
Tipo de produção
article
Data de publicação
2013
Título da Revista
ISSN da Revista
Título do Volume
Editora
INFORMA HEALTHCARE
Autores
MOURA, Filipe A.
DUTRA-RODRIGUES, Marcelo S.
CASSOL, Angela S.
PARRA, Eliane S.
ZAGO, Vanessa H. S.
PANZOLDO, Natalia B.
ALEXANDRE, Fernanda
VIEIRA, Isabela C.
VENDRAME, Felipe
VIRGINIO, Vitor W.
Citação
CHRONOBIOLOGY INTERNATIONAL, v.30, n.8, p.1011-1015, 2013
Resumo
Assessment of lipid profile parameters has been considered a cornerstone in classifying individuals and populations at risk for cardiovascular disease. Recently, however, preliminary data have raised the possibility of seasonal variations in these parameters, which may cause under- or overestimation. Biological rhythms and seasonal variation of lipid profile was investigated in 227 359 consecutive individuals who underwent health checkups in primary care centers between 2008 and 2010. Plasma low-density lipoprotein cholesterol (LDL-C) >130 mg/dL was 8% more prevalent during winter than summer, with a larger difference among women and middle-aged adults (p<0.001). High-density lipoprotein cholesterol (HDL-C) <40 mg/dL and triglycerides (TG) >150 mg/dL were respectively 9% and 5% more prevalent during the summer (p<0.001). Variation amplitude was 3.4 +/- 0.3 mg/dL for HDL-C (p = 0.005), 7 +/- 2 mg/dL for LDL-C (p = 0.047), and 12 +/- 9 mg/dL for TG (p = 0.058). Based on a large population sample, this study confirms the existence of biological rhythms and seasonal variation in lipid profile. This finding must be particularly accounted for in cross-sectional analyses of relative risk, prevalence, or the rate of goal achievement for lipid parameters.
Palavras-chave
Lipid profile, primary prevention, seasonality
Referências
- Alsheikh-Ali AA, 2007, AM J CARDIOL, V100, P1499, DOI 10.1016/j.amjcard.2007.06.058
- Bardini G, 2012, METABOLISM, V61, P1674, DOI 10.1016/j.metabol.2012.05.009
- Brinton EA, 2010, CURR OPIN LIPIDOL, V21, P346, DOI 10.1097/MOL.0b013e32833c1f41
- Catapano AL, 2011, ATHEROSCLEROSIS SUPP, V217, pS1
- Jorde R, 2011, PROG LIPID RES, V50, P303, DOI 10.1016/j.plipres.2011.05.001
- Knopp RH, 1997, JAMA-J AM MED ASSOC, V278, P1509, DOI 10.1001/jama.278.18.1509
- Leon AS, 2001, MED SCI SPORT EXER, V33, pS502, DOI 10.1097/00005768-200106001-00021
- Matthews CE, 2001, AM J EPIDEMIOL, V153, P172, DOI 10.1093/aje/153.2.172
- McQueen MJ, 2008, LANCET, V372, P224, DOI 10.1016/S0140-6736(08)61076-4
- MONTALBETTI N, 1989, CHRONOBIOLOGIA, V16, P409
- Nettleton JA, 2009, ATHEROSCLEROSIS, V203, P214, DOI 10.1016/j.atherosclerosis.2008.05.037
- Ockene IS, 2004, ARCH INTERN MED, V164, P863, DOI 10.1001/archinte.164.8.863
- Portaluppi F, 2010, CHRONOBIOL INT, V27, P1911, DOI 10.3109/07420528.2010.516381
- RASTAM L, 1992, AM J PREV MED, V8, P360
- RIVERACOLL A, 1994, CLIN CHEM, V40, P1549
- SMITH SJ, 1993, CLIN CHEM, V39, P1012
- Tung P, 2009, AM J CARDIOL, V103, P1056, DOI 10.1016/j.amjcard.2008.12.034
- Waters DD, 2009, CIRCULATION, V120, P28, DOI 10.1161/CIRCULATIONAHA.108.838466
- Zemel MB, 2000, FASEB J, V14, P1132