Prognostic value of regional metastasis in squamous cell carcinoma of the tongue and floor of mouth

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorAMAR, Ali
dc.contributor.authorRAPOPORT, Abrao
dc.contributor.authorCURIONI, Otavio Alberto
dc.contributor.authorDEDIVITIS, Rogerio Aparecido
dc.contributor.authorCERNEA, Claudio Roberto
dc.contributor.authorBRANDAO, Lenine Garcia
dc.date.accessioned2014-04-25T21:49:52Z
dc.date.available2014-04-25T21:49:52Z
dc.date.issued2013
dc.description.abstractThe presence of metastatic nodes is a survival-limiting factor for patients with mouth tumors. Objective: To evaluate the causes of treatment failure in carcinomas of the tongue and floor of the mouth due to staging. Method: This study included 365 patients with squamous cell carcinoma of the mouth treated from 1978 to 2007; 48 were staged as T1, 156 as T2, 98 as T3, and 63 as T4, of which 193 were pNo and 172 pN+. Results: Among the pN+ cases, 17/46 (36.9%) of the patients not treated with radiation therapy had relapsing tumors, against 46/126 (36.5 %) of the patients who underwent radiation therapy. Success rates in the group of subjects submitted to salvage procedures were 16/51 (31.3%) for pN0 patients and 3/77 (3.9%) for pN+ patients. Conclusion: Salvage procedure success and survival rates are lower for pN+ patients; pN+ individuals also have more relapsing local disease.
dc.description.abstractA presença da metástase linfonodal é um fator limitante da sobrevida no câncer da boca. Objetivo: Avaliar as causas de falha no tratamento dos carcinomas de língua e soalho de boca em função do estadiamento. Método: Foram analisados 365 casos de carcinoma epidermoide de boca, tratados de 1978 a 2007, sendo 48 T1, 156 T2, 98 T3 e 63 T4, dos quais 193 foram pNo e 172 pN+. Resultados: Entre os casos pN+, foram observados 17/46 recidivas (36,9%) nos casos não irradiados e 46/126 (36,5%) nos casos irradiados. Quanto aos resgates, nos casos pN0, obtivemos 16/51 (31,3%) e, nos pacientes pN+, de 3/77 (3,9%). Conclusão: O sucesso dos resgates é menor em pacientes com pN+, com maior recidiva local e menor sobrevida.
dc.description.indexMEDLINE
dc.identifier.citationBRAZILIAN JOURNAL OF OTORHINOLARYNGOLOGY, v.79, n.6, p.734-737, 2013
dc.identifier.doi10.5935/1808-8694.20130134
dc.identifier.eissn1808-8686
dc.identifier.issn1808-8694
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/5058
dc.language.isoeng
dc.language.isopor
dc.publisherASSOC BRASILEIRA OTORRINOLARINGOLOGIA & CIRURGIA CERVICOFACIAL
dc.relation.ispartofBrazilian Journal of Otorhinolaryngology
dc.rightsopenAccess
dc.rights.holderCopyright ASSOC BRASILEIRA OTORRINOLARINGOLOGIA & CIRURGIA CERVICOFACIAL
dc.subjectcarcinoma, squamous cell
dc.subjectlymphatic metastasis
dc.subjectmouth neoplasms
dc.subjectcarcinoma de células escamosas
dc.subjectmetástase linfática
dc.subjectneoplasias bucais
dc.subject.otherlymph-node metastases
dc.subject.otherpredictive factors
dc.subject.otherhead
dc.subject.wosOtorhinolaryngology
dc.titlePrognostic value of regional metastasis in squamous cell carcinoma of the tongue and floor of mouth
dc.title.alternativeValor prognóstico da metástase regional no carcinoma epidermoide de língua e soalho bucal
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalAMAR, Ali:Univ Fed Sao Paulo, Sao Paulo, Brazil; Heliopolis Hosp, Dept Head & Neck Surg & Otorhinolaryngol, Sao Paulo, Brazil
hcfmusp.citation.scopus5
hcfmusp.contributor.author-fmusphcABRAO RAPOPORT
hcfmusp.contributor.author-fmusphcOTAVIO ALBERTO CURIONI
hcfmusp.contributor.author-fmusphcROGERIO APARECIDO DEDIVITIS
hcfmusp.contributor.author-fmusphcCLAUDIO ROBERTO CERNEA
hcfmusp.contributor.author-fmusphcLENINE GARCIA BRANDAO
hcfmusp.description.beginpage734
hcfmusp.description.endpage737
hcfmusp.description.issue6
hcfmusp.description.volume79
hcfmusp.origemWOS
hcfmusp.origem.pubmed24474486
hcfmusp.origem.scieloSCIELO:S1808-86942013000600734
hcfmusp.origem.scopus2-s2.0-84892598408
hcfmusp.origem.wosWOS:000330031700014
hcfmusp.publisher.citySAO PAULO
hcfmusp.publisher.countryBRAZIL
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hcfmusp.scopus.lastupdate2024-05-10
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