Efficacy and safety of methylphenidate in treating ADHD symptoms in children and adolescents with uncontrolled seizures: A Brazilian sample study and literature review

Imagem de Miniatura
Arquivos
art_KONESKI_Efficacy_and_safety_of_methylphenidate_in_treating_ADHD_2011.PDF (178.09 KB)
Citações na Scopus
37
Tipo de produção
article
Data de publicação
2011
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
ACADEMIC PRESS INC ELSEVIER SCIENCE
Autores
KONESKI, Julio A. S.
AGERTT, Fabio
FERREIRA, Maria Gabriela
Citação
EPILEPSY & BEHAVIOR, v.21, n.3, p.228-232, 2011
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Objective: Attention-deficit/hyperactivity disorder (ADHD) is observed in 30% of children and adolescents with epilepsy. Recent studies have demonstrated the safety of methylphenidate (MPH) in patients with controlled epilepsy. There are few studies of patients with uncontrolled epilepsy. The goal was to study the efficacy and safety of MPH use in children and adolescents diagnosed with ADHD and uncontrolled epilepsy. Methods: We evaluated 24 patients ranging from 7 to 16 years of age who took MPH for 6 months. Inclusion criteria were at least two epileptic seizures in the previous 6 months and a diagnosis of ADHD based on DSM-IV criteria. Conclusion: Patients were classified according to ADHD subtype as follows: 41.7% inattentive type, 37.5% combined, and 20.8% hyperactive/impulsive type; 58.3% had partial epilepsy and 41.7% generalized epilepsy. There was an overall improvement in ADHD symptoms in 70.8% of patients, and there was no increase in frequency of epileptic seizures in 22 patients (91.6%).
Palavras-chave
Attention-deficit/hyperactivity disorder, Epilepsy, Methylphenidate, Attention-deficit/hyperactivity disorder and comorbidity, Behavior
URI
https://observatorio.fm.usp.br/handle/OPI/23803
Referências
  1. Aldenkamp AP, 2006, NEUROLOGY, V67, pS49
  2. American Psychiatric Association, 1994, DIAGN STAT MAN MENT
  3. Lahey BB, 2005, ARCH GEN PSYCHIAT, V62, P896, DOI 10.1001/archpsyc.62.8.896
  4. Hermann B, 2007, BRAIN, V130, P3135, DOI 10.1093/brain/awm227
  5. McAfee AT, 2007, EPILEPSIA, V48, P1075, DOI 10.1111/j.1528-1167.2007.01108.x
  6. Pisani F, 2002, DRUG SAFETY, V25, P91, DOI 10.2165/00002018-200225020-00004
  7. Sherman EMS, 2007, EPILEPSIA, V48, P1083, DOI 10.1111/j.1528-1167.2007.01028.x
  8. Faraone SV, 2004, J CLIN PSYCHOPHARM, V24, P24, DOI 10.1097/01.jcp.0000108984.11879.95
  9. Zaccara G, 2009, ACTA NEUROL SCAND, V120, P1, DOI 10.1111/j.1600-0404.2008.01146.x
  10. Moore JL, 2002, EPILEPSY BEHAV, V3, P92, DOI 10.1006/ebeh.2001.0313
  11. Dunn DW, 2003, DEV MED CHILD NEUROL, V45, P50, DOI 10.1017/S0012162203000094
  12. Turky A, 2008, EPILEPSY BEHAV, V12, P136, DOI 10.1016/j.yebeh.2007.08.003
  13. Koneski JAS, 2010, ARQ NEURO-PSIQUIAT, V68, P107, DOI 10.1590/S0004-282X2010000100023
  14. Semrud-Clikeman M, 1999, EPILEPSIA, V40, P211, DOI 10.1111/j.1528-1157.1999.tb02077.x
  15. Handen BL, 1998, J ABNORM CHILD PSYCH, V26, P269, DOI 10.1023/A:1022654417460
  16. Baptista-Neto L, 2008, EXPERT OPIN INV DRUG, V17, P77, DOI 10.1517/13543784.17.1.77
  17. Biederman J, 2005, LANCET, V366, P237, DOI 10.1016/S0140-6736(05)66915-2
  18. Parisi P, 2010, BRAIN DEV-JPN, V32, P10, DOI 10.1016/j.braindev.2009.03.005
  19. Nissen SE, 2006, NEW ENGL J MED, V354, P1445, DOI 10.1056/NEJMp068049
  20. Jones JE, 2007, DEV MED CHILD NEUROL, V49, P493
  21. Davies S, 2003, DEV MED CHILD NEUROL, V45, P292, DOI 10.1017/S0012162203000550
  22. Jensen PS, 1999, ARCH GEN PSYCHIAT, V56, P1073
  23. Van der Oord S, 2008, CLIN PSYCHOL REV, V28, P783, DOI 10.1016/j.cpr.2007.10.007
  24. Davis SM, 2010, PEDIATR NEUROL, V42, P325, DOI 10.1016/j.pediatrneurol.2010.01.005
  25. Gucuyener K, 2003, J CHILD NEUROL, V18, P109, DOI 10.1177/08830738030180020601
  26. Hesdorffer DC, 2004, ARCH GEN PSYCHIAT, V61, P731, DOI 10.1001/archpsyc.61.7.731
  27. FELDMAN H, 1989, AM J DIS CHILD, V143, P1081
  28. GrossTsur V, 1997, J PEDIATR-US, V130, P670, DOI 10.1016/S0022-3476(97)70258-0
  29. Ben-Ari Y, 2006, LANCET NEUROL, V5, P1055, DOI 10.1016/S1474-4422(06)70626-3
  30. Kaufmann R, 2009, J CHILD NEUROL, V24, P727, DOI [10.1177/0883073808330165, 10.1177/0883073809330165]
  31. [Anonymous], 2000, REV BRAS PSIQUIAT S2, DOI 10.1590/S1516-44462000000600015
  32. FINCK S, 1995, ANN NEUROL, V38, P520
  33. Kadesjo B, 2001, J CHILD PSYCHOL PSYC, V42, P487, DOI 10.1017/S0021963001007090
  34. Thome-Souza S, 2004, EPILEPSY BEHAV, V5, P988, DOI 10.1016/j.yebeh.2004.09.001
  35. Engel J, 2001, EPILEPSIA, V42, P796, DOI 10.1046/j.1528-1157.2001.10401.x
  36. Patsalos PN, 2008, EPILEPSIA, V49, P1239, DOI 10.1111/j.1528-1167.2008.01561.x
  37. MCBRIDE MC, 1986, ANN NEUROL, V20, P428
  38. Fabiano GA, 2009, CLIN PSYCHOL REV, V29, P129, DOI 10.1016/j.cpr.2008.11.001
  39. Hemmer SA, 2001, PEDIATR NEUROL, V24, P99, DOI 10.1016/S0887-8994(00)00240-X
  40. Dunn DW, 2009, DEV MED CHILD NEUROL, V51, P364, DOI 10.1111/j.1469-8749.2008.03172.x
  41. Torres AR, 2008, EPILEPSY BEHAV, V12, P217, DOI 10.1016/j.yebeh.2007.08.001
  42. Schubert R, 2005, PEDIATR NEUROL, V32, P1, DOI 10.1016/j.pediatrneurol.2004.06.007
  43. Antshel KM, 2006, CLIN PSYCHOL REV, V26, P555, DOI 10.1016/j.cpr.2006.03.002
  44. Bechtel N, 2009, EPILEPSY BEHAV, V15, P294, DOI 10.1016/j.yebeh.2009.04.005
  45. Correia Filho Alceu Gomes, 2005, J Am Acad Child Adolesc Psychiatry, V44, P748, DOI 10.1097/01.chi.0000166986.30592.67
  46. Bordin I. A. S., 1995, Revista ABP-APAL (Associacao Brasileira de Psiquiatria-Asociacion Psiquiatrica de la America Latina), V17, P55
  47. Commission on Classification and Terminology of the International League Against Epilepsy, 1989, EPILEPSIA, V30, P389
  48. Dunn David W, 2005, Semin Pediatr Neurol, V12, P222, DOI 10.1016/j.spen.2005.12.004
  49. Dunn DW, 2004, EPILEPSY BEHAV, V5, pS10, DOI 10.1016/j.yebeh.2004.06.011
  50. Faraone Stephen V, 2003, World Psychiatry, V2, P104
  51. Gonzalez-Heydrich J, 2007, EPILEPSY BEHAV, V10, P384, DOI 10.1016/j.yebeh.2007.01.010
  52. Gonzalez-Heydrich J, 2006, J AM ACAD CHILD PSY, V45, P1527, DOI 10.1097/01.chi.0000240836.71361.39
  53. Gonzalez-Heydrich J, 2004, AM AC CHILD AD PSYCH
  54. Gonzalez-Heydrich J, 2010, EPILEPSY BEHAV, V18, P229, DOI 10.1016/j.yebeh.2010.02.022
  55. GONZALEZHEYDRIC.J, 2006, AM AC CHILD AD PSYCH
  56. Greenhill Laurence L., 2002, Journal of the American Academy of Child and Adolescent Psychiatry, V41, p26S
  57. Greenhill LL, 2001, J AM ACAD CHILD PSY, V40, P1352
  58. Hanssen-Bauer K, 2007, EPILEPSY BEHAV, V10, P255, DOI 10.1016/j.yebeh.2006.11.011
  59. Hermann Bruce P, 2007, Semin Pediatr Neurol, V14, P173, DOI 10.1016/j.spen.2007.08.003
  60. BANCAUD J, 1981, EPILEPSIA, V22, P489
  61. Kanner AM, 2008, SEMIN NEUROL, V28, P379, DOI 10.1055/s-2008-1079342
  62. Lampert T L, 2004, J Atten Disord, V8, P63, DOI 10.1177/108705470400800204
  63. Mattos Paulo, 2006, Rev. psiquiatr. Rio Gd. Sul, V28, P290, DOI 10.1590/S0101-81082006000300008
  64. Mulas F, 2004, REV NEUROLOGIA, V39, P192
  65. PALMINI A, 2004, J EPILEPSY CLIN N S2, V10, P53
  66. Pellock JM, 2004, NEUROLOGY, V62, pS17
  67. Rohde LA, 1999, J AM ACAD CHILD PSY, V38, P716, DOI 10.1097/00004583-199906000-00019
  68. Sanchez-Carpintero R, 2003, EPILEPSIA, V44, P1340, DOI 10.1046/j.1528-1157.2003.16403.x
  69. Souza I, 2001, ARQ NEURO-PSIQUIAT, V59, P401, DOI 10.1590/S0004-282X2001000300017
  70. Tan M, 2005, ARCH DIS CHILD, V90, P57, DOI 10.1136/adc.2003.048504
  71. Teicher MH, 2006, J CHILD ADOL PSYCHOP, V16, P416, DOI 10.1089/cap.2006.16.416
  72. Van der Feltz-Cornelis CM, 2006, EPILEPSY BEHAV, V8, P659, DOI 10.1016/j.yebeh.2006.01.015
  73. Weber P, 2002, PEDIATR NEUROL, V26, P261, DOI 10.1016/S0887-8994(01)00408-8
  74. WESCHLER D, 2002, WISC 3 ESCALA INTELI
  75. Wiegartz P, 1999, NEUROLOGY, V53, pS3
  76. WROBLEWSKI BA, 1992, J CLIN PSYCHIAT, V53, P86

Coleções
Artigos e Materiais de Revistas Científicas - HC/ICr