Changes in cartilage, synovial cells and synovial fluid after malleolar fractures: What its importance for post-traumatic ankle osteoarthitis?

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorGODOY-SANTOS, A.L.
dc.contributor.authorLOPES, D.
dc.contributor.authorGIAROLA, I.
dc.contributor.authorCESAR NETTO, C. de
dc.contributor.authorRAMMELT, S.
dc.date.accessioned2020-04-03T16:18:46Z
dc.date.available2020-04-03T16:18:46Z
dc.date.issued2019
dc.description.abstractBackground: Despite advances in malleolar fractures treatment, the overall risk to develop posttraumatic ankle osteoarthritis after 20 years is almost 40%, especially bimalleolar Weber type B and C fractures and fractures involving the posterior tibial rim. Methods: We performed a systematic literature review of clinical studies targeting the changes in cartilage, synovial cells and synovial fluid after malleolar fractures. Results: The acute ankle injury initiates a sequence of biological events potentially leading to progressive articular surface damage resulting from inflammatory changes in cartilage, synovial tissue and synovial fluid. Conclusion: A better understanding of the molecular and histological changes induced by acute trauma may potentially lead to novel, targeted treatment of malleolar fractures besides anatomical reduction and adequate stabilization. © 2019eng
dc.description.indexScopuseng
dc.identifier.citationFUSS UND SPRUNGGELENK, v.17, n.2, p.68-74, 2019
dc.identifier.doi10.1016/j.fuspru.2019.03.002
dc.identifier.issn1619-9987
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/35738
dc.language.isopor
dc.publisherELSEVIER GMBHeng
dc.relation.ispartofFuss und Sprunggelenk
dc.rightsrestrictedAccesseng
dc.rights.holderCopyright ELSEVIER GMBHeng
dc.subjectAnkle fractureeng
dc.subjectCartilageeng
dc.subjectOsteoarthritiseng
dc.subjectSynovialeng
dc.titleChanges in cartilage, synovial cells and synovial fluid after malleolar fractures: What its importance for post-traumatic ankle osteoarthitis?eng
dc.title.alternativeVeränderungen in Knorpel, Synovialzellen und Synovialflüssigkeit nach Malleolarfrakturen: Welche Bedeutung hat es für die posttraumatische Osteoarthritis des Sprunggelenks?
dc.typearticleeng
dc.type.categoryrevieweng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.affiliation.countryEstados Unidos
hcfmusp.affiliation.countryAlemanha
hcfmusp.affiliation.countryisous
hcfmusp.affiliation.countryisode
hcfmusp.author.externalCESAR NETTO, C. de:Department of Orthopedics Foot and Ankle Surgery, Hospital for Special Surgery, New York, United States
hcfmusp.author.externalRAMMELT, S.:UniversitätsCentrum für Orthopädie und Unfallchirurgie, Universitätsklinikum Carl Gustav Carus, Dresden, Germany
hcfmusp.citation.scopus2
hcfmusp.contributor.author-fmusphcALEXANDRE LEME GODOY DOS SANTOS
hcfmusp.contributor.author-fmusphcDEBORA MARIA BEFI LOPES
hcfmusp.contributor.author-fmusphcIVAN CARVALHO GIAROLA
hcfmusp.description.beginpage68
hcfmusp.description.endpage74
hcfmusp.description.issue2
hcfmusp.description.volume17
hcfmusp.origemSCOPUS
hcfmusp.origem.scopus2-s2.0-85063677792
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