Diagnostic accuracy of a noninvasive hepatic ultrasound score for non-alcoholic fatty liver disease (NAFLD) in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorGOULART, Alessandra Carvalho
dc.contributor.authorOLIVEIRA, Ilka Regina Souza de
dc.contributor.authorALENCAR, Airlane Pereira
dc.contributor.authorSANTOS, Maira Solange Camara dos
dc.contributor.authorSANTOS, Itamar Souza
dc.contributor.authorMARTINES, Brenda Margatho Ramos
dc.contributor.authorMEIRELES, Danilo Peron
dc.contributor.authorMARTINES, Joao Augusto dos Santos
dc.contributor.authorMISCIAGNA, Giovanni
dc.contributor.authorBENSENOR, Isabela Martins
dc.contributor.authorLOTUFO, Paulo Andrade
dc.date.accessioned2015-10-26T16:26:29Z
dc.date.available2015-10-26T16:26:29Z
dc.date.issued2015
dc.description.abstractCONTEXT AND OBJECTIVE: Noninvasive strategies for evaluating non-alcoholic fatty liver disease (NAFLD) have been investigated over the last few decades. Our aim was to evaluate the diagnostic accuracy of a new hepatic ultrasound score for NAFLD in the ELSA-Brasil study. DESIGN AND SETTINGS: Diagnostic accuracy study conducted in the ELSA center, in the hospital of a public university. METHODS: Among the 15,105 participants of the ELSA study who were evaluated for NAFLD, 195 individuals were included in this sub-study. Hepatic ultrasound was performed (deep beam attenuation, hepatorenal index and anteroposterior diameter of the right hepatic lobe) and compared with the hepatic steatosis findings from 64-channel high-resolution computed tomography (CT). We also evaluated two clinical indices relating to NAFLD: the fatty liver index (FLI) and the hepatic steatosis index (HSI). RESULTS: Among the 195 participants, the NAFLD frequency was 34.4%. High body mass index, high waist circumference, diabetes and hypertriglyceridemia were associated with high hepatic attenuation and large anteroposterior diameter of the right hepatic lobe, but not with the hepatorenal index. The hepatic ultrasound score, based on hepatic attenuation and the anteroposterior diameter of the right hepatic lobe, presented the best performance for NAFLD screening at the cutoff point >= 1 point; sensitivity: 85.1%; specificity: 73.4%; accuracy: 79.3%; and area under the curve (AUC 0.85; 95% confidence interval, CI: 0.78-0.91)]. FLI and HSI presented lower performance (AUC 0.76; 95% CI: 0.69-0.83) than CT. CONCLUSION: The hepatic ultrasound score based on hepatic attenuation and the anteroposterior diameter of the right hepatic lobe has good reproducibility and accuracy for NAFLD screening.
dc.description.indexMEDLINE
dc.description.sponsorshipBrazilian Ministry of Health (Science and Technology Department)
dc.description.sponsorshipBrazilian Ministry of Science and Technology (Funding Agency for Studies and Projects) [01 06 0010.00 RS, 01 060212.00 BA, 01 06 0300.00 ES, 01 06 0278.00 MG, 01 06 0115.00 SP, 01 060071.00 RJ]
dc.description.sponsorshipBrazilian Ministry of Science and Technology (CNPq National Research Council) [01 06 0010.00 RS, 01 060212.00 BA, 01 06 0300.00 ES, 01 06 0278.00 MG, 01 06 0115.00 SP, 01 060071.00 RJ]
dc.identifier.citationSAO PAULO MEDICAL JOURNAL, v.133, n.2, p.115-124, 2015
dc.identifier.doi10.1590/1516-3180.2014.9150812
dc.identifier.issn1516-3180
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/11618
dc.language.isoeng
dc.publisherASSOCIACAO PAULISTA MEDICINA
dc.relation.ispartofSao Paulo Medical Journal
dc.rightsopenAccess
dc.rights.holderCopyright ASSOCIACAO PAULISTA MEDICINA
dc.subjectLiver disease
dc.subjectEpidemiology
dc.subjectDiagnostic techniques and procedures
dc.subjectUltrasonography
dc.subjectTomography, x-ray computed
dc.subject.otherhepatorenal index
dc.subject.othercardiovascular-disease
dc.subject.othercomputed-tomography
dc.subject.othersteatosis
dc.subject.otherattenuation
dc.subject.otherct
dc.subject.otherpopulation
dc.subject.otherrisk
dc.subject.otherquantification
dc.subject.otherbackscatter
dc.subject.wosMedicine, General & Internal
dc.titleDiagnostic accuracy of a noninvasive hepatic ultrasound score for non-alcoholic fatty liver disease (NAFLD) in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)
dc.title.alternativeAcurácia diagnóstica de um escore de ultrassonografia hepática não invasivo para doença hepática gordurosa não alcoólica (DHGNA) no Estudo Longitudinal de Saúde do Adulto (ELSA-Brasil)
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.affiliation.countryItália
hcfmusp.affiliation.countryisoit
hcfmusp.author.externalALENCAR, Airlane Pereira:Univ Sao Paulo, Inst Math & Stat, Stat & Math, BR-09500900 Sao Paulo, Brazil
hcfmusp.author.externalMARTINES, Joao Augusto dos Santos:FMUSP, Dept Radiol, Sao Paulo, Brazil
hcfmusp.author.externalMISCIAGNA, Giovanni:Univ Bari, Univ Hosp, Researcher Eth Comm, I-70121 Bari, Italy
hcfmusp.citation.scopus22
hcfmusp.contributor.author-fmusphcALESSANDRA CARVALHO GOULART
hcfmusp.contributor.author-fmusphcILKA REGINA SOUZA DE OLIVEIRA
hcfmusp.contributor.author-fmusphcMAIRA SOLANGE CAMARA DOS SANTOS
hcfmusp.contributor.author-fmusphcITAMAR DE SOUZA SANTOS
hcfmusp.contributor.author-fmusphcBRENDA MARGATHO RAMOS MARTINES
hcfmusp.contributor.author-fmusphcDANILO PERON MEIRELES
hcfmusp.contributor.author-fmusphcISABELA JUDITH MARTINS BENSEñOR
hcfmusp.contributor.author-fmusphcPAULO ANDRADE LOTUFO
hcfmusp.description.beginpage115
hcfmusp.description.endpage124
hcfmusp.description.issue2
hcfmusp.description.volume133
hcfmusp.origemWOS
hcfmusp.origem.pubmed26018881
hcfmusp.origem.scieloSCIELO:S1516-31802015000200115
hcfmusp.origem.scopus2-s2.0-84929688378
hcfmusp.origem.wosWOS:000355314900008
hcfmusp.publisher.citySAO PAULO
hcfmusp.publisher.countryBRAZIL
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