EPILAT-IRA Study: A contribution to the understanding of the epidemiology of acute kidney injury in Latin America

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorLOMBARDI, Raul
dc.contributor.authorFERREIRO, Alejandro
dc.contributor.authorGRANADO, Rolando Claure-Del
dc.contributor.authorBURDMANN, Emmanuel A.
dc.contributor.authorROSA-DIEZ, Guillermo
dc.contributor.authorYU, Luis
dc.contributor.authorYOUNES-IBRAHIM, Mauricio
dc.contributor.authorCARLINO, Cristina
dc.contributor.authorCHAVEZ-INIGUEZ, Jonathan S.
dc.contributor.authorPEREIRE, Mariana B.
dc.contributor.authorVARELA, Carlos F.
dc.contributor.authorZAMONER, Welder
dc.contributor.authorJANIQUES, Diego
dc.contributor.authorLECUEDER, Soledad
dc.contributor.authorCERRON-MILLAN, Victor
dc.contributor.authorCUETO-MANZANO, Alfonso
dc.contributor.groupauthorEPILAT-ITA Study Grp
dc.date.accessioned2020-08-20T13:19:51Z
dc.date.available2020-08-20T13:19:51Z
dc.date.issued2019
dc.description.abstractIntroduction Epidemiology of acute kidney injury (AKI) is highly dependent on patient characteristics, context and geography. Considering the limited information in Latin America and the Caribbean, we performed a study with the aim to contribute to improve its better understanding. Methods Observational, prospective, longitudinal, multinational cohort study addressed to determine risk factors, clinical profile, process of care and outcomes of AKI in the region. Patients meeting KDIGO AKI definition were included over a 9-month period and designated community or hospital-acquired. De-identified clinical and lab data were entered in a specifically designed on-line platform. Co-variables potentially linked to AKI onset, in-hospital and 90-days mortality, were recorded and correlated using a multiple logistic regression model. Results Fifty-seven physicians from 15 countries provided data on 905 patients, most with acceptable basic needs coverage. Median age 64 (50-74) yrs; most of them were male (61%) and mestizos (42%). Comorbidities were present in 77%. AKI was community-acquired in 62%. Dehydration, shock and nephrotoxic drugs were the commonest causes. During their process of care, 77% of patients were assessed by nephrologists. Kidney replacement therapy (KRT) was performed in 29% of cases. In-hospital mortality was 26.5% and independently associated to older age, chronic liver disease, hypotension, shock, cardiac disturbances, hospital-acquired sepsis, KRT and mechanical ventilation. At 90-days follow up partial or complete renal recovery was 81% and mortality 24%. Conclusions AKI was mainly community-acquired, in patients with comorbidities and linked to fluid loss and nephrotoxic drugs. Mortality was high and long-term follow up poor. Notwithstanding, the study shows partially the situation in the participant countries rather than the actual epidemiology of AKI in Latin America and Caribbean, a pending and needed task.eng
dc.description.indexMEDLINEeng
dc.description.sponsorshipAKI Commission of the Latin American Society of Nephrology and Hypertension
dc.identifier.citationPLOS ONE, v.14, n.11, article ID e0224655, 14p, 2019
dc.identifier.doi10.1371/journal.pone.0224655
dc.identifier.issn1932-6203
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/36731
dc.language.isoeng
dc.publisherPUBLIC LIBRARY SCIENCEeng
dc.relation.ispartofPlos One
dc.rightsopenAccesseng
dc.rights.holderCopyright PUBLIC LIBRARY SCIENCEeng
dc.subject.otheracute-renal-failureeng
dc.subject.otherintensive-care unitseng
dc.subject.otherinternational societyeng
dc.subject.otherreplacement therapyeng
dc.subject.otherraising awarenesseng
dc.subject.wosMultidisciplinary Scienceseng
dc.titleEPILAT-IRA Study: A contribution to the understanding of the epidemiology of acute kidney injury in Latin Americaeng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.affiliation.countryBolívia
hcfmusp.affiliation.countryArgentina
hcfmusp.affiliation.countryMéxico
hcfmusp.affiliation.countryPeru
hcfmusp.affiliation.countryUruguai
hcfmusp.affiliation.countryisouy
hcfmusp.affiliation.countryisobo
hcfmusp.affiliation.countryisoar
hcfmusp.affiliation.countryisomx
hcfmusp.affiliation.countryisope
hcfmusp.author.externalLOMBARDI, Raul:Univ Republica, Sch Med, Dept Nephrol, Montevideo, Uruguay
hcfmusp.author.externalFERREIRO, Alejandro:Univ Republica, Sch Med, Dept Nephrol, Montevideo, Uruguay
hcfmusp.author.externalGRANADO, Rolando Claure-Del:Univ Mayor, San Simon Sch Med, Hosp Obrero CNS Univ 2, Div Nephrol, Cochabamba, Bolivia
hcfmusp.author.externalROSA-DIEZ, Guillermo:Hosp Italiano Buenos Aires, Dept Nehrol, Buenos Aires, DF, Argentina
hcfmusp.author.externalYOUNES-IBRAHIM, Mauricio:Univ Rio de Janeiro, Dept Internal Med, Rio De Janeiro, Brazil
hcfmusp.author.externalCARLINO, Cristina:Hosp Prov, Rosario, Santa Fe, Argentina
hcfmusp.author.externalCHAVEZ-INIGUEZ, Jonathan S.:Hosp Civil Guadalajara, Ctr Univ Ciencias Salud, Guadalajara, Jalisco, Mexico
hcfmusp.author.externalPEREIRE, Mariana B.:Univ Nove Julho, Hosp Servidor Publ Estadual, Nephrol Div, Sao Paulo, Brazil
hcfmusp.author.externalVARELA, Carlos F.:Hosp Italiano Buenos Aires, Dept Nehrol, Buenos Aires, DF, Argentina
hcfmusp.author.externalZAMONER, Welder:Sao Paulo State Univ UNESP, Botucatu Sch Med, Sao Paulo, Brazil
hcfmusp.author.externalJANIQUES, Diego:Pontificia Univ Catolica, Clin Renalle, Petropolis, RJ, Brazil
hcfmusp.author.externalLECUEDER, Soledad:Sanatorio Casa Galicia, Montevideo, Uruguay
hcfmusp.author.externalCERRON-MILLAN, Victor:Hosp Nacl Daniel Alcides Carrion, Serv Nefrol, Dept Med, Callao Lima, Peru
hcfmusp.author.externalCUETO-MANZANO, Alfonso:Hosp Especialidades Ctr Med La Raza, Med Res Unit Renal Dis, CMNO, IMSS, Guadalajara, Mexico
hcfmusp.citation.scopus16
hcfmusp.contributor.author-fmusphcEMMANUEL DE ALMEIDA BURDMANN
hcfmusp.contributor.author-fmusphcLUIS YU
hcfmusp.description.articlenumbere0224655
hcfmusp.description.issue11
hcfmusp.description.volume14
hcfmusp.origemWOS
hcfmusp.origem.pubmed31725746
hcfmusp.origem.scopus2-s2.0-85075071489
hcfmusp.origem.wosWOS:000532764500022
hcfmusp.publisher.citySAN FRANCISCOeng
hcfmusp.publisher.countryUSAeng
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