S100B is downregulated in the nuclear proteome of schizophrenia corpus callosum

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorSTEINER, Johann
dc.contributor.authorSCHMITT, Andrea
dc.contributor.authorSCHROETER, Matthias L.
dc.contributor.authorBOGERTS, Bernhard
dc.contributor.authorFALKAI, Peter
dc.contributor.authorTURCK, Christoph W.
dc.contributor.authorMARTINS-DE-SOUZA, Daniel
dc.date.accessioned2015-02-06T19:59:39Z
dc.date.available2015-02-06T19:59:39Z
dc.date.issued2014
dc.description.abstractHere we report the downregulation of S100B in the nuclear proteome of the corpus callosum from nine schizophrenia patients compared to seven mentally healthy controls. Our data have been obtained primarily by mass spectrometry and later confirmed by Western blot. This is an intriguing finding coming from a brain region which is essentially composed by white matter, considering the potential role of S100B in the control of oligodendrocyte maturation. This data reinforce the importance of oligodendrocytes in schizophrenia, shedding more light to its pathobiology.
dc.description.indexMEDLINE
dc.description.sponsorshipFAPESP (Sao Paulo Research Foundation), Brazil [2013/08711-3]
dc.identifier.citationEUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE, v.264, n.4, p.311-316, 2014
dc.identifier.doi10.1007/s00406-014-0490-z
dc.identifier.eissn1433-8491
dc.identifier.issn0940-1334
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/8797
dc.language.isoeng
dc.publisherSPRINGER HEIDELBERG
dc.relation.ispartofEuropean Archives of Psychiatry and Clinical Neuroscience
dc.rightsrestrictedAccess
dc.rights.holderCopyright SPRINGER HEIDELBERG
dc.subjectS100B
dc.subjectCorpus callosum
dc.subjectWhite matter
dc.subjectOligodendrocytes
dc.subjectProteomics
dc.subjectMass spectrometry
dc.subject.otherserum-levels
dc.subject.otherbrain
dc.subject.otherglia
dc.subject.othercells
dc.subject.wosClinical Neurology
dc.subject.wosPsychiatry
dc.titleS100B is downregulated in the nuclear proteome of schizophrenia corpus callosum
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.affiliation.countryAlemanha
hcfmusp.affiliation.countryisode
hcfmusp.author.externalSTEINER, Johann:Univ Magdeburg, Dept Psychiat, D-39106 Magdeburg, Germany; Ctr Behav Brain Sci, Magdeburg, Germany
hcfmusp.author.externalSCHROETER, Matthias L.:Max Planck Inst Cognit & Human Brain Sci, Leipzig, Germany; Univ Hosp, Clin Cognit Neurol, Leipzig, Germany
hcfmusp.author.externalBOGERTS, Bernhard:Univ Magdeburg, Dept Psychiat, D-39106 Magdeburg, Germany; Ctr Behav Brain Sci, Magdeburg, Germany
hcfmusp.author.externalFALKAI, Peter:Ludwig Maximilians Univ Munich LMU, Dept Psychiat & Psychotherapy, Munich, Germany
hcfmusp.author.externalTURCK, Christoph W.:Max Planck Inst Psychiat, D-80804 Munich, Germany
hcfmusp.citation.scopus19
hcfmusp.contributor.author-fmusphcANDREA SCHMITT
hcfmusp.contributor.author-fmusphcDANIEL MARTINS DE SOUZA
hcfmusp.description.beginpage311
hcfmusp.description.endpage316
hcfmusp.description.issue4
hcfmusp.description.volume264
hcfmusp.origemWOS
hcfmusp.origem.scopus2-s2.0-84903643592
hcfmusp.origem.wosWOS:000339883300005
hcfmusp.publisher.cityHEIDELBERG
hcfmusp.publisher.countryGERMANY
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