Antileukotriene Reverts the Early Effects of Inflammatory Response of Distal Parenchyma in Experimental Chronic Allergic Inflammation

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorGOBBATO, Nathalia Brandao
dc.contributor.authorSOUZA, Flavia Castro Ribas de
dc.contributor.authorFUMAGALLI, Stella Bruna Napolitano
dc.contributor.authorLOPES, Fernanda Degobbi Tenorio Quirino dos Santos
dc.contributor.authorPRADO, Carla Maximo
dc.contributor.authorMARTINS, Milton Arruda
dc.contributor.authorTIBERIO, Iolanda de Fatima Lopes Calvo
dc.contributor.authorLEICK, Edna Aparecida
dc.date.accessioned2014-01-28T22:17:23Z
dc.date.available2014-01-28T22:17:23Z
dc.date.issued2013
dc.description.abstractAims. Compare the effects of montelukast or dexamethasone in distal lung parenchyma and airway walls of guinea pigs (GP) with chronic allergic inflammation. Methods. GP have inhaled ovalbumin (OVA group-2x/week/4weeks). After the 4th inhalation, GP were treated with montelukast or dexamethasone. After 72 hours of the 7th inhalation, GP were anesthetised, and lungs were removed and submitted to histopathological evaluation. Results. Montelukast and dexamethasone treatments reduced the number of eosinophils in airway wall and distal lung parenchyma compared to OVA group (P < 0.05). On distal parenchyma, both treatments were effective in reducing RANTES, NF-kappa B, and fibronectin positive cells compared to OVA group (P < 0.001). Montelukast was more effective in reducing eotaxin positive cells on distal parenchyma compared to dexamethasone treatment (P < 0.001), while there was a more expressive reduction of IGF-I positive cells in OVA-D group (P < 0.001). On airway walls, montelukast and dexamethasone were effective in reducing IGF-I, RANTES, and fibronectin positive cells compared to OVA group (P < 0.05). Dexamethasone was more effective in reducing the number of eotaxin and NF-kappa B positive cells than Montelukast (P < 0.05). Conclusions. In this animal model, both treatments were effective in modulating allergic inflammation and remodeling distal lung parenchyma and airway wall, contributing to a better control of the inflammatory response.
dc.description.indexMEDLINE
dc.description.sponsorshipCoordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico and Tecnologico (CNPq), Brazil
dc.description.sponsorshipBrazilian agency Laboratories for Medical Research(LIMs), Hospital das Clinicas, University of Sao Paulo Medical School [FMUSP-HC/LIM-20]
dc.identifier.citationBIOMED RESEARCH INTERNATIONAL, article ID 523761, 15p, 2013
dc.identifier.doi10.1155/2013/523761
dc.identifier.issn2314-6133
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/3930
dc.language.isoeng
dc.publisherHINDAWI PUBLISHING CORPORATION
dc.relation.ispartofBiomed Research International
dc.rightsopenAccess
dc.rights.holderCopyright HINDAWI PUBLISHING CORPORATION
dc.subject.otherleukotriene receptor antagonist
dc.subject.otherobstructive pulmonary-disease
dc.subject.othernf-kappa-b
dc.subject.otherlung-tissue mechanics
dc.subject.othermouse asthma model
dc.subject.otherinhaled corticosteroids
dc.subject.otherairway inflammation
dc.subject.otherguinea-pigs
dc.subject.othereosinophilic inflammation
dc.subject.othercysteinyl leukotrienes
dc.subject.wosBiotechnology & Applied Microbiology
dc.subject.wosMedicine, Research & Experimental
dc.titleAntileukotriene Reverts the Early Effects of Inflammatory Response of Distal Parenchyma in Experimental Chronic Allergic Inflammation
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalFUMAGALLI, Stella Bruna Napolitano:Univ Sao Paulo, Sch Med, Dept Med, BR-01246903 Sao Paulo, Brazil
hcfmusp.author.externalPRADO, Carla Maximo:Univ Fed Sao Paulo, Dept Biol Sci, BR-09972270 Diadema, SP, Brazil
hcfmusp.citation.scopus4
hcfmusp.contributor.author-fmusphcNATHALIA BRANDAO GOBBATO
hcfmusp.contributor.author-fmusphcFLAVIA CASTRO RIBAS DE SOUZA
hcfmusp.contributor.author-fmusphcFERNANDA DEGOBBI TENORIO QUIRINO DOS SANTOS LOPES
hcfmusp.contributor.author-fmusphcMILTON DE ARRUDA MARTINS
hcfmusp.contributor.author-fmusphcIOLANDA DE FATIMA LOPES CALVO TIBERIO
hcfmusp.contributor.author-fmusphcEDNA APARECIDA LEICK
hcfmusp.description.articlenumber523761
hcfmusp.description.volume2013
hcfmusp.origemWOS
hcfmusp.origem.pubmed24151607
hcfmusp.origem.scopus2-s2.0-84885615980
hcfmusp.origem.wosWOS:000325019100001
hcfmusp.publisher.cityNEW YORK
hcfmusp.publisher.countryUSA
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