Skeletal muscle histidine-containing dipeptide contents are increased in freshwater turtles (C. picta bellii) with cold-acclimation

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0
Tipo de produção
article
Data de publicação
2021
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
ELSEVIER SCIENCE INC
Autores
DOLAN, Eimear
WARREN, Daniel E.
HARRIS, Roger C.
SALE, Craig
Citação
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY, v.262, article ID 111071, 6p, 2021
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Freshwater turtles found in higher latitudes can experience extreme challenges to acid-base homeostasis while overwintering, due to a combination of cold temperatures along with the potential for environmental hypoxia. Histidine-containing dipeptides (HCDs; carnosine, anserine and balenine) may facilitate pH regulation in response to these challenges, through their role as pH buffers. We measured the HCD content of three tissues (liver, cardiac and skeletal muscle) from the anoxia-tolerant painted turtle (C. picta bellii) acclimated to either 3 or 20 degrees C. HCDs were detected in all tissues, with the highest content shown in the skeletal muscle. Turtles acclimated to 3 degrees C had more HCD in their skeletal muscle than those acclimated to 20 degrees C (carnosine = 20.8 +/- 4.5 vs 12.5 +/- 5.9 mmol. kg DM-1; ES = 1.59 (95%CI: 0.16-3.00), P = 0.013). The higher HCD content shown in the skeletal muscle of the cold-acclimated turtles suggests a role in acid-base regulation in response to physiological challenges associated with living in the cold, with the increase possibly related to the temperature sensitivity of carnosine's dissociation constant.
Palavras-chave
Alphastat, pH, Acid-base, Carnosine, Buffering, Hypoxia, Hibernation
URI
https://observatorio.fm.usp.br/handle/OPI/44331
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MCM
Artigos e Materiais de Revistas Científicas - LIM/17