The unexpected presence of iron in bone biopsies of hemodialysis patients

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art_CUSTODIO_The_unexpected_presence_of_iron_in_bone_biopsies_2018.PDF (1014.88 KB)
Citações na Scopus
2
Tipo de produção
article
Data de publicação
2018
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
SPRINGER
Autores
VELASQUEZ, Wagner D.
CARVALHO, Aluizio B.
Citação
INTERNATIONAL UROLOGY AND NEPHROLOGY, v.50, n.10, p.1907-1912, 2018
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Purpose Bone biopsy defines classical diseases that constitute the renal osteodystrophy. There is a recent concern regarding other histological findings that are not appreciated by using the turnover, mineralization, and volume (TMV) classification. Iron (Fe) overload has been considered a new challenge and the real significance of the presence of this metal in bones is not completely elucidated. Therefore, the main goal of the current study was to not only to identify bone Fe, but also correlate its presence with demographic, and biochemical characteristics. Methods This is a cross-sectional analysis of bone biopsies performed in 604 patients on dialysis from 2010 to 2014 in a tertiary academic Hospital. Results Histomorphometric findings revealed the presence of Fe in 29.1%. Fe was associated with higher levels of serum ferritin and serum calcium. No TMV status was related to Fe bone overload. Conclusion Our study has highlighted that the presence of Fe in one-third of bone samples has unknown clinical significance. The lack of other contemporary bone biopsy study reporting Fe prevents us from comparison. The findings presented here should be specifically addressed in a future research and will require attention prior to implementation of any clinical guideline. If any proposed treatment, however, would change the bone Fe-related morbidity is undetermined.
Palavras-chave
Bone biopsy, Iron, Dialysis, Histomorphometry, Ferritin
URI
https://observatorio.fm.usp.br/handle/OPI/29647
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Coleções
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/16