Using structural MRI to identify bipolar disorders-13 site machine learning study in 3020 individuals from the ENIGMA Bipolar Disorders Working Group

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorNUNES, Abraham
dc.contributor.authorSCHNACK, Hugo G.
dc.contributor.authorCHING, Christopher R. K.
dc.contributor.authorAGARTZ, Ingrid
dc.contributor.authorAKUDJEDU, Theophilus N.
dc.contributor.authorALDA, Martin
dc.contributor.authorALNAES, Dag
dc.contributor.authorALONSO-LANA, Silvia
dc.contributor.authorBAUER, Jochen
dc.contributor.authorBAUNE, Bernhard T.
dc.contributor.authorBOEN, Erlend
dc.contributor.authorBONNIN, Caterina del Mar
dc.contributor.authorBUSATTO, Geraldo F.
dc.contributor.authorCANALES-RODRIGUEZ, Erick J.
dc.contributor.authorCANNON, Dara M.
dc.contributor.authorCASERAS, Xavier
dc.contributor.authorCHAIM-AVANCINI, Tiffany M.
dc.contributor.authorDANNLOWSKI, Udo
dc.contributor.authorDIAZ-ZULUAGA, Ana M.
dc.contributor.authorDIETSCHE, Bruno
dc.contributor.authorNhat Trung Doan
dc.contributor.authorDUCHESNAY, Edouard
dc.contributor.authorELVSASHAGEN, Torbjorn
dc.contributor.authorEMDEN, Daniel
dc.contributor.authorEYLER, Lisa T.
dc.contributor.authorFATJO-VILAS, Mar
dc.contributor.authorFAVRE, Pauline
dc.contributor.authorFOLEY, Sonya F.
dc.contributor.authorFULLERTON, Janice M.
dc.contributor.authorGLAHN, David C.
dc.contributor.authorGOIKOLEA, Jose M.
dc.contributor.authorGROTEGERD, Dominik
dc.contributor.authorHAHN, Tim
dc.contributor.authorHENRY, Chantal
dc.contributor.authorHIBAR, Derrek P.
dc.contributor.authorHOUENOU, Josselin
dc.contributor.authorHOWELLS, Fleur M.
dc.contributor.authorJAHANSHAD, Neda
dc.contributor.authorKAUFMANN, Tobias
dc.contributor.authorKENNEY, Joanne
dc.contributor.authorKIRCHER, Tilo T. J.
dc.contributor.authorKRUG, Axel
dc.contributor.authorV, Trine Lagerberg
dc.contributor.authorLENROOT, Rhoshel K.
dc.contributor.authorLOPEZ-JARAMILLO, Carlos
dc.contributor.authorMACHADO-VIEIRA, Rodrigo
dc.contributor.authorMALT, Ulrik F.
dc.contributor.authorMCDONALD, Colm
dc.contributor.authorMITCHELL, Philip B.
dc.contributor.authorMWANGI, Benson
dc.contributor.authorNABULSI, Leila
dc.contributor.authorOPEL, Nils
dc.contributor.authorOVERS, Bronwyn J.
dc.contributor.authorPINEDA-ZAPATA, Julian A.
dc.contributor.authorPOMAROL-CLOTET, Edith
dc.contributor.authorREDLICH, Ronny
dc.contributor.authorROBERTS, Gloria
dc.contributor.authorROSA, Pedro G.
dc.contributor.authorSALVADOR, Raymond
dc.contributor.authorSATTERTHWAITE, Theodore D.
dc.contributor.authorSOARES, Jair C.
dc.contributor.authorSTEIN, Dan J.
dc.contributor.authorTEMMINGH, Henk S.
dc.contributor.authorTRAPPENBERG, Thomas
dc.contributor.authorUHLMANN, Anne
dc.contributor.authorHAREN, Neeltje E. M. van
dc.contributor.authorVIETA, Eduard
dc.contributor.authorWESTLYE, Lars T.
dc.contributor.authorWOLF, Daniel H.
dc.contributor.authorYUEKSEL, Dilara
dc.contributor.authorZANETTI, Marcus V.
dc.contributor.authorANDREASSEN, Ole A.
dc.contributor.authorTHOMPSON, Paul M.
dc.contributor.authorHAJEK, Tomas
dc.contributor.groupauthorENIGMA Bipolar Disorders Working G
dc.date.accessioned2020-10-15T14:38:22Z
dc.date.available2020-10-15T14:38:22Z
dc.date.issued2020
dc.description.abstractBipolar disorders (BDs) are among the leading causes of morbidity and disability. Objective biological markers, such as those based on brain imaging, could aid in clinical management of BD. Machine learning (ML) brings neuroimaging analyses to individual subject level and may potentially allow for their diagnostic use. However, fair and optimal application of ML requires large, multi-site datasets. We applied ML (support vector machines) to MRI data (regional cortical thickness, surface area, subcortical volumes) from 853 BD and 2167 control participants from 13 cohorts in the ENIGMA consortium. We attempted to differentiate BD from control participants, investigated different data handling strategies and studied the neuroimaging/clinical features most important for classification. Individual site accuracies ranged from 45.23% to 81.07%. Aggregate subject-level analyses yielded the highest accuracy (65.23%, 95% CI = 63.47-67.00, ROC-AUC = 71.49%, 95% CI = 69.39-73.59), followed by leave-one-site-out cross-validation (accuracy = 58.67%, 95% CI = 56.70-60.63). Meta-analysis of individual site accuracies did not provide above chance results. There was substantial agreement between the regions that contributed to identification of BD participants in the best performing site and in the aggregate dataset (Cohen's Kappa = 0.83, 95% CI = 0.829-0.831). Treatment with anticonvulsants and age were associated with greater odds of correct classification. Although short of the 80% clinically relevant accuracy threshold, the results are promising and provide a fair and realistic estimate of classification performance, which can be achieved in a large, ecologically valid, multi-site sample of BD participants based on regional neurostructural measures. Furthermore, the significant classification in different samples was based on plausible and similar neuroanatomical features. Future multi-site studies should move towards sharing of raw/voxelwise neuroimaging data.eng
dc.description.indexMEDLINEeng
dc.description.sponsorshipMedical Research CouncilMedical Research Council UK (MRC) [MR/L010305/1] Funding Source: Medline
dc.description.sponsorshipNHLBI NIH HHSUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Heart Lung & Blood Institute (NHLBI) [R01 HL113323] Funding Source: Medline
dc.description.sponsorshipNIA NIH HHSUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute on Aging (NIA) [R01 AG058464] Funding Source: Medline
dc.description.sponsorshipNIBIB NIH HHSUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Biomedical Imaging & Bioengineering (NIBIB) [U54 EB020403] Funding Source: Medline
dc.description.sponsorshipNIMH NIH HHSUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Mental Health (NIMH) [R01 MH101111, R01 MH083968, R56 MH097940, R01 MH106324, U01 MH119690, R01 MH080912, R01 MH107703, U01 MH105630, R01 MH107248, K23 MH085096, R01 MH083824, R01 MH078143] Funding Source: Medline
dc.identifier.citationMOLECULAR PSYCHIATRY, v.25, n.9, p.2130-2143, 2020
dc.identifier.doi10.1038/s41380-018-0228-9
dc.identifier.eissn1476-5578
dc.identifier.issn1359-4184
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/37878
dc.language.isoeng
dc.publisherSPRINGERNATUREeng
dc.relation.ispartofMolecular Psychiatry
dc.rightsopenAccesseng
dc.rights.holderCopyright SPRINGERNATUREeng
dc.subject.othersupport vector machineeng
dc.subject.otherpattern-recognitioneng
dc.subject.otherneuroimaging dataeng
dc.subject.othermood disorderseng
dc.subject.othergenetic riskeng
dc.subject.otherbraineng
dc.subject.otherbiomarkerseng
dc.subject.otherschizophreniaeng
dc.subject.otherclassificationeng
dc.subject.othermetaanalysiseng
dc.subject.wosBiochemistry & Molecular Biologyeng
dc.subject.wosNeuroscienceseng
dc.subject.wosPsychiatryeng
dc.titleUsing structural MRI to identify bipolar disorders-13 site machine learning study in 3020 individuals from the ENIGMA Bipolar Disorders Working Groupeng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.affiliation.countryHolanda
hcfmusp.affiliation.countryCanadá
hcfmusp.affiliation.countryNoruega
hcfmusp.affiliation.countryEspanha
hcfmusp.affiliation.countryAlemanha
hcfmusp.affiliation.countryAustrália
hcfmusp.affiliation.countryPaís de Gales
hcfmusp.affiliation.countryColômbia
hcfmusp.affiliation.countryFrança
hcfmusp.affiliation.countryÁfrica do Sul
hcfmusp.affiliation.countryIrlanda
hcfmusp.affiliation.countrySuécia
hcfmusp.affiliation.countryEstados Unidos
hcfmusp.affiliation.countryisoca
hcfmusp.affiliation.countryisonl
hcfmusp.affiliation.countryisous
hcfmusp.affiliation.countryisose
hcfmusp.affiliation.countryisoie
hcfmusp.affiliation.countryisono
hcfmusp.affiliation.countryisoes
hcfmusp.affiliation.countryisode
hcfmusp.affiliation.countryisoau
hcfmusp.affiliation.countryisogb
hcfmusp.affiliation.countryisoco
hcfmusp.affiliation.countryisofr
hcfmusp.affiliation.countryisoza
hcfmusp.author.externalNUNES, Abraham:Dalhousie Univ, Dept Psychiat, Halifax, NS, Canada; Dalhousie Univ, Fac Comp Sci, Halifax, NS, Canada
hcfmusp.author.externalSCHNACK, Hugo G.:Univ Utrecht, Univ Med Ctr Utrecht, Brain Ctr Rudolf Magnus, Dept Psychiat, Utrecht, Netherlands
hcfmusp.author.externalCHING, Christopher R. K.:Univ Calif Los Angeles, Interdept Neurosci Program, Los Angeles, CA USA; Univ Southern Calif, Keck Sch Med USC, Mark & Mary Stevens Neuroimaging & Informat Inst, Imaging Genet Ctr, Marina Del Rey, CA USA
hcfmusp.author.externalAGARTZ, Ingrid:Univ Oslo, NORMENT KG Jebsen Ctr, Oslo, Norway; Oslo Univ Hosp, Div Mental Hlth & Addict, Oslo, Norway; Diakonhjemmet Hosp, Dept Psychiat Res, Oslo, Norway; Karolinska Inst, Ctr Psychiat Res, Dept Clin Neurosci, Stockholm, Sweden
hcfmusp.author.externalAKUDJEDU, Theophilus N.:Natl Univ Ireland Galway, Coll Med Nursing & Hlth Sci, NCBES Galway Neurosci Ctr, Ctr Neuroimaging & Cognit Genom NICOG,Clin Neuroi, Galway, Ireland
hcfmusp.author.externalALDA, Martin:Dalhousie Univ, Dept Psychiat, Halifax, NS, Canada
hcfmusp.author.externalALNAES, Dag:Univ Oslo, NORMENT KG Jebsen Ctr, Oslo, Norway; Oslo Univ Hosp, Div Mental Hlth & Addict, Oslo, Norway
hcfmusp.author.externalALONSO-LANA, Silvia:FIDMAG Germanes Hosp Res Fdn, Barcelona, Spain; Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
hcfmusp.author.externalBAUER, Jochen:Univ Munster, Inst Clin Radiol, Med Fac, Munster, Germany; Univ Hosp Muenster, Munster, Germany
hcfmusp.author.externalBAUNE, Bernhard T.:Univ Melbourne, Melbourne Med Sch, Dept Psychiat, Parkville, Vic, Australia
hcfmusp.author.externalBOEN, Erlend:Diakonhjemmet Hosp, Dept Psychiat Res, Oslo, Norway
hcfmusp.author.externalBONNIN, Caterina del Mar:Univ Barcelona, Hosp Clin, CIBERSAM, IDIBAPS, Barcelona, Catalonia, Spain
hcfmusp.author.externalCANALES-RODRIGUEZ, Erick J.:FIDMAG Germanes Hosp Res Fdn, Barcelona, Spain; Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
hcfmusp.author.externalCANNON, Dara M.:Natl Univ Ireland Galway, Coll Med Nursing & Hlth Sci, NCBES Galway Neurosci Ctr, Ctr Neuroimaging & Cognit Genom NICOG,Clin Neuroi, Galway, Ireland
hcfmusp.author.externalCASERAS, Xavier:Cardiff Univ, MRC Ctr Neuropsychiat Genet & Genom, Cardiff, Wales
hcfmusp.author.externalDANNLOWSKI, Udo:Univ Munster, Dept Psychiat, Munster, Germany
hcfmusp.author.externalDIAZ-ZULUAGA, Ana M.:Univ Antioquia, Fac Med, Dept Psychiat, Res Grp Psychiat, Medellin, Antioquia, Colombia
hcfmusp.author.externalDIETSCHE, Bruno:Philipps Univ Marburg, Dept Psychiat & Psychotherapy, Marburg, Germany
hcfmusp.author.externalNhat Trung Doan:Univ Oslo, NORMENT KG Jebsen Ctr, Oslo, Norway; Oslo Univ Hosp, Div Mental Hlth & Addict, Oslo, Norway
hcfmusp.author.externalDUCHESNAY, Edouard:Paris Saclay, CEA, NeuroSpin, Gif Sur Yvette, France
hcfmusp.author.externalELVSASHAGEN, Torbjorn:Univ Oslo, NORMENT KG Jebsen Ctr, Oslo, Norway; Oslo Univ Hosp, Dept Neurol, Oslo, Norway
hcfmusp.author.externalEMDEN, Daniel:Univ Munster, Dept Psychiat, Munster, Germany
hcfmusp.author.externalEYLER, Lisa T.:Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA; VA San Diego Healthcare Syst, Desert Pacific Mental Illness Res Educ & Clin Ctr, La Jolla, CA USA
hcfmusp.author.externalFATJO-VILAS, Mar:FIDMAG Germanes Hosp Res Fdn, Barcelona, Spain; Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain; Univ Barcelona, Fac Biol, Dept Biol Evolut Ecol & Ciencies Ambientals, Barcelona, Spain
hcfmusp.author.externalFAVRE, Pauline:Paris Saclay, CEA, NeuroSpin, Gif Sur Yvette, France
hcfmusp.author.externalFOLEY, Sonya F.:Cardiff Univ, Brain Res Imaging Ctr, Cardiff, Wales
hcfmusp.author.externalFULLERTON, Janice M.:Neurosci Res Australia, Sydney, NSW, Australia; Univ New South Wales, Sch Med Sci, Sydney, NSW, Australia
hcfmusp.author.externalGLAHN, David C.:Yale Univ, Dept Psychiat, New Haven, CT 06520 USA; Hartford Hosp, Inst Living, Olin Neuropsychiat Res Ctr, Hartford, CT 06115 USA
hcfmusp.author.externalGOIKOLEA, Jose M.:Univ Barcelona, Hosp Clin, CIBERSAM, IDIBAPS, Barcelona, Catalonia, Spain
hcfmusp.author.externalGROTEGERD, Dominik:Univ Munster, Dept Psychiat, Munster, Germany
hcfmusp.author.externalHAHN, Tim:Univ Munster, Dept Psychiat, Munster, Germany
hcfmusp.author.externalHENRY, Chantal:Inst Pasteur, Unite Percept & Memoire, Paris, France
hcfmusp.author.externalHIBAR, Derrek P.:Univ Southern Calif, Keck Sch Med USC, Mark & Mary Stevens Neuroimaging & Informat Inst, Imaging Genet Ctr, Marina Del Rey, CA USA
hcfmusp.author.externalHOUENOU, Josselin:Paris Saclay, CEA, NeuroSpin, Gif Sur Yvette, France; Univ Paris East, AP HP, INSERM U955 Team 15 Translat Psychiat, CHU Mondor,Fdn FondaMental, Creteil, France
hcfmusp.author.externalHOWELLS, Fleur M.:Univ Cape Town, Neurosci Inst, Cape Town, South Africa; Dept Psychiat & Mental Hlth, Translat Neurosci Grp, Cape Town, South Africa
hcfmusp.author.externalJAHANSHAD, Neda:Univ Southern Calif, Keck Sch Med USC, Mark & Mary Stevens Neuroimaging & Informat Inst, Imaging Genet Ctr, Marina Del Rey, CA USA
hcfmusp.author.externalKAUFMANN, Tobias:Univ Oslo, NORMENT KG Jebsen Ctr, Oslo, Norway; Oslo Univ Hosp, Div Mental Hlth & Addict, Oslo, Norway
hcfmusp.author.externalKENNEY, Joanne:Natl Univ Ireland Galway, Coll Med Nursing & Hlth Sci, NCBES Galway Neurosci Ctr, Ctr Neuroimaging & Cognit Genom NICOG,Clin Neuroi, Galway, Ireland
hcfmusp.author.externalKIRCHER, Tilo T. J.:Philipps Univ Marburg, Dept Psychiat & Psychotherapy, Marburg, Germany
hcfmusp.author.externalKRUG, Axel:Philipps Univ Marburg, Dept Psychiat & Psychotherapy, Marburg, Germany
hcfmusp.author.externalV, Trine Lagerberg:Univ Oslo, NORMENT KG Jebsen Ctr, Oslo, Norway
hcfmusp.author.externalLENROOT, Rhoshel K.:Univ New South Wales, Sch Psychiat, Sydney, NSW, Australia; Univ New Mexico, Dept Psychiat & Behav Sci, Albuquerque, NM 87131 USA
hcfmusp.author.externalLOPEZ-JARAMILLO, Carlos:Univ Antioquia, Fac Med, Dept Psychiat, Res Grp Psychiat, Medellin, Antioquia, Colombia; Hosp Univ San Vicente Fdn, Mood Disorders Program, Medellin, Antioquia, Colombia
hcfmusp.author.externalMALT, Ulrik F.:Oslo Univ Hosp, Psychosomat Unit, Div Mental Hlth & Dependence, Oslo, Norway; Univ Oslo, Oslo, Norway; Univ Oslo, Inst Clin Med, Oslo, Norway
hcfmusp.author.externalMCDONALD, Colm:Natl Univ Ireland Galway, Coll Med Nursing & Hlth Sci, NCBES Galway Neurosci Ctr, Ctr Neuroimaging & Cognit Genom NICOG,Clin Neuroi, Galway, Ireland
hcfmusp.author.externalMITCHELL, Philip B.:Univ New South Wales, Sch Psychiat, Sydney, NSW, Australia; Prince Wales Hosp, Black Dog Inst, Sydney, NSW, Australia
hcfmusp.author.externalMWANGI, Benson:Univ Texas Hlth Sci Ctr Houston, Dept Psychiat, Houston, TX 77030 USA
hcfmusp.author.externalNABULSI, Leila:Natl Univ Ireland Galway, Coll Med Nursing & Hlth Sci, NCBES Galway Neurosci Ctr, Ctr Neuroimaging & Cognit Genom NICOG,Clin Neuroi, Galway, Ireland
hcfmusp.author.externalOPEL, Nils:Univ Munster, Dept Psychiat, Munster, Germany
hcfmusp.author.externalOVERS, Bronwyn J.:Neurosci Res Australia, Sydney, NSW, Australia
hcfmusp.author.externalPINEDA-ZAPATA, Julian A.:Inst Alta Tecnol Med IATM, Res Grp, Medellin, Antioquia, Colombia
hcfmusp.author.externalPOMAROL-CLOTET, Edith:FIDMAG Germanes Hosp Res Fdn, Barcelona, Spain; Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
hcfmusp.author.externalREDLICH, Ronny:Univ Munster, Dept Psychiat, Munster, Germany
hcfmusp.author.externalROBERTS, Gloria:Univ New South Wales, Sch Psychiat, Sydney, NSW, Australia; Prince Wales Hosp, Black Dog Inst, Sydney, NSW, Australia
hcfmusp.author.externalSALVADOR, Raymond:FIDMAG Germanes Hosp Res Fdn, Barcelona, Spain; Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
hcfmusp.author.externalSATTERTHWAITE, Theodore D.:Univ Penn, Dept Psychiat, Philadelphia, PA 19104 USA
hcfmusp.author.externalSOARES, Jair C.:Univ Texas Hlth Sci Ctr Houston, Dept Psychiat, Houston, TX 77030 USA
hcfmusp.author.externalSTEIN, Dan J.:Univ Cape Town, Dept Psychiat, SA MRC Unit Risk & Resilience Mental Disorders, Cape Town, South Africa
hcfmusp.author.externalTEMMINGH, Henk S.:Univ Cape Town, Dept Psychiat, SA MRC Unit Risk & Resilience Mental Disorders, Cape Town, South Africa; Valkenberg Hosp, Western Cape Dept Hlth, Cape Town, Western Cape, South Africa
hcfmusp.author.externalTRAPPENBERG, Thomas:Dalhousie Univ, Fac Comp Sci, Halifax, NS, Canada
hcfmusp.author.externalUHLMANN, Anne:Univ Cape Town, Dept Psychiat, SA MRC Unit Risk & Resilience Mental Disorders, Cape Town, South Africa; Univ Vermont, Dept Psychiat, Burlington, VT USA
hcfmusp.author.externalHAREN, Neeltje E. M. van:Univ Utrecht, Univ Med Ctr Utrecht, Brain Ctr Rudolf Magnus, Dept Psychiat, Utrecht, Netherlands; Erasmus MC, Dept Child & Adolescent Psychiat Psychol, Rotterdam, Netherlands
hcfmusp.author.externalVIETA, Eduard:Univ Barcelona, Hosp Clin, CIBERSAM, IDIBAPS, Barcelona, Catalonia, Spain
hcfmusp.author.externalWESTLYE, Lars T.:Univ Oslo, NORMENT KG Jebsen Ctr, Oslo, Norway; Oslo Univ Hosp, Div Mental Hlth & Addict, Oslo, Norway; Univ Oslo, Dept Psychol, Oslo, Norway
hcfmusp.author.externalWOLF, Daniel H.:Univ Penn, Dept Psychiat, Philadelphia, PA 19104 USA
hcfmusp.author.externalYUEKSEL, Dilara:Philipps Univ Marburg, Dept Psychiat & Psychotherapy, Marburg, Germany
hcfmusp.author.externalANDREASSEN, Ole A.:Univ Oslo, NORMENT KG Jebsen Ctr, Oslo, Norway; Oslo Univ Hosp, Div Mental Hlth & Addict, Oslo, Norway
hcfmusp.author.externalTHOMPSON, Paul M.:Univ Southern Calif, Keck Sch Med USC, Mark & Mary Stevens Neuroimaging & Informat Inst, Imaging Genet Ctr, Marina Del Rey, CA USA
hcfmusp.author.externalHAJEK, Tomas:Dalhousie Univ, Dept Psychiat, Halifax, NS, Canada
hcfmusp.citation.scopus78
hcfmusp.contributor.author-fmusphcGERALDO BUSATTO FILHO
hcfmusp.contributor.author-fmusphcTIFFANY MOUKBEL CHAIM AVANCINI
hcfmusp.contributor.author-fmusphcRODRIGO MACHADO VIEIRA
hcfmusp.contributor.author-fmusphcPEDRO GOMES PENTEADO ROSA
hcfmusp.contributor.author-fmusphcMARCUS VINICIUS ZANETTI
hcfmusp.description.beginpage2130
hcfmusp.description.endpage2143
hcfmusp.description.issue9
hcfmusp.description.volume25
hcfmusp.origemWOS
hcfmusp.origem.pubmed30171211
hcfmusp.origem.scopus2-s2.0-85053320480
hcfmusp.origem.wosWOS:000565914600020
hcfmusp.publisher.cityLONDONeng
hcfmusp.publisher.countryENGLANDeng
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