Sex differences in the association between alcohol intake and cognitive decline over 4 years in a middle-aged cohort: The Brazilian Longitudinal Study of Adult Health

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorSALVADOR, Larissa
dc.contributor.authorGIATTI, Luana
dc.contributor.authorVIANA, Maria Carmen
dc.contributor.authorSUEMOTO, Claudia Kimie
dc.contributor.authorDUNCAN, Bruce B.
dc.contributor.authorMOLINA, Maria del Carmen Bisi
dc.contributor.authorFONSECA, Maria de Jesus Mendes da
dc.contributor.authorBRUNONI, Andre R.
dc.contributor.authorBARRETO, Sandhi Maria
dc.contributor.authorCARAMELLI, Paulo
dc.date.accessioned2022-08-12T17:03:41Z
dc.date.available2022-08-12T17:03:41Z
dc.date.issued2022
dc.description.abstractBackground and purpose The association between alcohol intake and cognitive decline has been widely studied. Sex differences and cognitive domains affected by alcohol intake patterns make this topic complex. The objective of this study was to investigate the effect of alcohol intake on cognition in middle-aged participants in the Brazilian Longitudinal Study of Adult Health by sex during 4 years of follow-up. Methods A total of 7595 participants (55% women) aged between 50 and 75 years at baseline were assessed. Semantic and phonemic fluency, memory, and executive functions were assessed at baseline (2008-2010) and repeated during Visit 2. Linear mixed models were used to investigate the association between cognition and current abstainers, never drinkers, light drinkers, moderate drinkers, and heavy drinkers. Results Heavy alcohol intake accentuated the decline in executive functions for men (beta = -0.01, p < 0.05), and in semantic fluency (beta = -0.02, p < 0.05) and memory (beta = -0.02, p < 0.05) for women. Never drinker men also showed an accentuated decline in semantic fluency (beta = -0.02, p < 0.01). Moderate alcohol intake slowed cognitive decline in phonemic fluency for men (beta = 0.02, p < 0.01) and women (beta = 0.01, p < 0.01), and in executive functions (beta = 0.01, p < 0.05) for women. Conclusions Having more than 14 drinks per week can impact executive functions in men and memory in women. In addition, alcohol consumption of seven to 14 drinks per week may have a protective effect on gender-specific cognitive functions. These findings should be considered in public health policies and guidelines on alcohol and cognitive aging.eng
dc.description.indexMEDLINEeng
dc.description.sponsorshipBrazilian Ministry of Health (Department of Science and Technology)
dc.description.sponsorshipBrazilian Ministry of Science, Technology, and Innovation (Financiadora de Estudos e Projetos)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico [CNPq] [01 06 0010.00, 01 06 0212.00, 01 06 0300.00, 01 06 0278.00, 01 06 0115.00, 01 06 0071.00]
dc.identifier.citationEUROPEAN JOURNAL OF NEUROLOGY, v.29, n.7, p.1903-1912, 2022
dc.identifier.doi10.1111/ene.15315
dc.identifier.eissn1468-1331
dc.identifier.issn1351-5101
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/48288
dc.language.isoeng
dc.publisherWILEYeng
dc.relation.ispartofEuropean Journal of Neurology
dc.rightsrestrictedAccesseng
dc.rights.holderCopyright WILEYeng
dc.subjectalcohol drinkingeng
dc.subjectcognitioneng
dc.subjectcognitive disruptionseng
dc.subjectepidemiologyeng
dc.subjectsexeng
dc.subject.otherlate-lifeeng
dc.subject.otherconsumptioneng
dc.subject.otherbraineng
dc.subject.othermortalityeng
dc.subject.otherdementiaeng
dc.subject.wosClinical Neurologyeng
dc.subject.wosNeuroscienceseng
dc.titleSex differences in the association between alcohol intake and cognitive decline over 4 years in a middle-aged cohort: The Brazilian Longitudinal Study of Adult Healtheng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.author.externalSALVADOR, Larissa:Univ Fed Minas Gerais, Fac Med, Postgrad Program Appl Sci Adult Hlth, Belo Horizonte, MG, Brazil
hcfmusp.author.externalGIATTI, Luana:Univ Fed Minas Gerais, Sch Med & Clin Hosp, Belo Horizonte, MG, Brazil
hcfmusp.author.externalVIANA, Maria Carmen:Univ Fed Espirito Santo, Ctr Estudo & Pesquisa Epidemiol Psiquiatr CEPEP U, Dept Social Med, Vitoria, MG, Brazil; Univ Fed Espirito Santo, Ctr Estudo & Pesquisa Epidemiol Psiquiatr CEPEP U, Postgrad Program Publ Hlth, Vitoria, MG, Brazil
hcfmusp.author.externalDUNCAN, Bruce B.:Univ Fed Rio Grande do Sul, Postgrad Program Epidemiol & Clin Hosp, Porto Alegre, RS, Brazil
hcfmusp.author.externalMOLINA, Maria del Carmen Bisi:Univ Fed Espirito Santo, Univ Fed Ouro Preto, Postgrad Program Hlth & Nutr, Postgrad Program Publ Hlth, Ouro Preto, MG, Brazil
hcfmusp.author.externalFONSECA, Maria de Jesus Mendes da:Fundacao Oswaldo Cruz, Dept Epidemiol & Quantitat Methods Hlth, Escola Nacl Saude Publ, Rio De Janeiro, Brazil
hcfmusp.author.externalBRUNONI, Andre R.:Univ Fed Minas Gerais, Sch Med & Clin Hosp, Belo Horizonte, MG, Brazil
hcfmusp.author.externalBARRETO, Sandhi Maria:Univ Fed Minas Gerais, Sch Med & Clin Hosp, Belo Horizonte, MG, Brazil
hcfmusp.author.externalCARAMELLI, Paulo:Univ Fed Minas Gerais, Fac Med, Postgrad Program Appl Sci Adult Hlth, Belo Horizonte, MG, Brazil; Univ Fed Minas Gerais, Fac Med, Dept Clin Med, Behav & Cognit Neurol Res Grp, Belo Horizonte, MG, Brazil
hcfmusp.citation.scopus1
hcfmusp.contributor.author-fmusphcCLAUDIA KIMIE SUEMOTO
hcfmusp.description.beginpage1903
hcfmusp.description.endpage1912
hcfmusp.description.issue7
hcfmusp.description.volume29
hcfmusp.origemWOS
hcfmusp.origem.pubmed35262995
hcfmusp.origem.scopus2-s2.0-85127301581
hcfmusp.origem.wosWOS:000773477800001
hcfmusp.publisher.cityHOBOKENeng
hcfmusp.publisher.countryUSAeng
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