Gene expression alterations in the postmortem hippocampus from older patients with bipolar disorder-A hypothesis generating study

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorNASCIMENTO, Camila
dc.contributor.authorKIM, Helena Kyunghee
dc.contributor.authorNUNES, Paula Villela
dc.contributor.authorLEITE, Renata Elaine Paraiso
dc.contributor.authorCRISTINA, De Oliveira Katia
dc.contributor.authorBARBOSA, Andre
dc.contributor.authorBERTONHA, Fernanda Bernardi
dc.contributor.authorMOREIRA-FILHO, Carlos Alberto
dc.contributor.authorJACOB-FILHO, Wilson
dc.contributor.authorNITRINI, Ricardo
dc.contributor.authorPASQUALUCCI, Carlos A.
dc.contributor.authorGRINBERG, Lea Tenenholz
dc.contributor.authorSUEMOTO, Claudia Kimie
dc.contributor.authorBRENTANI, Helena Paula
dc.contributor.authorLAFER, Beny
dc.date.accessioned2023-08-16T18:01:52Z
dc.date.available2023-08-16T18:01:52Z
dc.date.issued2023
dc.description.abstractBipolar disorder (BD) presents with a progressive course in a subset of patients. However, our knowledge of molecular changes in older BD is limited. In this study, we examined gene expression changes in the hippocampus of BD from the Biobank of Aging Studies to identify genes of interest that warrant further exploration. RNA was extracted from the hippocampus from 11 subjects with BD and 11 age and sex-matched controls. Gene expression data was generated using the SurePrint G3 Human Gene Expression v3 microarray. Rank feature selection was performed to identify a subset of features that can optimally differentiate BD and controls. Genes ranked in the top 0.1% with log2 fold change >1.2 were identified as genes of interest. Average age of the subjects was 64 years old; duration of disease was 21 years and 82% were female. Twenty-five genes were identified, of which all but one was downregulated in BD. Of these, CNTNAP4, MAP4, SLC4A1, COBL, and NEURL4 had been associated with BD and other psychiatric conditions in previous studies. We believe our findings have identified promising targets to inform future studies aiming to understand the pathophysiology of BD in later life.eng
dc.description.indexMEDLINE
dc.description.indexPubMed
dc.description.indexWoS
dc.description.indexScopus
dc.description.sponsorshipNational Council for Scientific and Technological Development (CNPq) [466763/2014-0]
dc.description.sponsorshipSao Paulo Research Foundation (FAPESP) [2017/07089-8]
dc.identifier.citationJOURNAL OF PSYCHIATRIC RESEARCH, v.164, p.329-334, 2023
dc.identifier.doi10.1016/j.jpsychires.2023.06.002
dc.identifier.eissn1879-1379
dc.identifier.issn0022-3956
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/54751
dc.language.isoeng
dc.publisherPERGAMON-ELSEVIER SCIENCE LTDeng
dc.relation.ispartofJournal of Psychiatric Research
dc.rightsrestrictedAccesseng
dc.rights.holderCopyright PERGAMON-ELSEVIER SCIENCE LTDeng
dc.subjectBipolar disordereng
dc.subjectTranscriptomeeng
dc.subjectGene expressioneng
dc.subjectHippocampuseng
dc.subjectPostmortem braineng
dc.subject.otherfrontal-cortexeng
dc.subject.otherpathwayseng
dc.subject.otherstresseng
dc.subject.othersuicideeng
dc.subject.otherdnaeng
dc.subject.wosPsychiatryeng
dc.titleGene expression alterations in the postmortem hippocampus from older patients with bipolar disorder-A hypothesis generating studyeng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.affiliation.countryCanadá
hcfmusp.affiliation.countryisoca
hcfmusp.author.externalKIM, Helena Kyunghee:Univ Toronto, Dept Psychiat, Toronto, ON, Canada
hcfmusp.author.externalCRISTINA, De Oliveira Katia:Fed Univ ABC, Sao Bernardo Do Campo, SP, Brazil
hcfmusp.author.externalBARBOSA, Andre:Univ Sao Paulo, Dept Psychiat, Med Sch, Sao Paulo, SP, Brazil
hcfmusp.citation.scopus1
hcfmusp.contributor.author-fmusphcCAMILA APARECIDA NASCIMENTO DOS SANTOS LIMA
hcfmusp.contributor.author-fmusphcPAULA VILLELA NUNES
hcfmusp.contributor.author-fmusphcRENATA ELAINE PARAIZO LEITE
hcfmusp.contributor.author-fmusphcFERNANDA BERNARDI BERTONHA
hcfmusp.contributor.author-fmusphcCARLOS ALBERTO MOREIRA FILHO
hcfmusp.contributor.author-fmusphcWILSON JACOB FILHO
hcfmusp.contributor.author-fmusphcRICARDO NITRINI
hcfmusp.contributor.author-fmusphcCARLOS AUGUSTO GONCALVES PASQUALUCCI
hcfmusp.contributor.author-fmusphcLEA TENENHOLZ GRINBERG
hcfmusp.contributor.author-fmusphcCLAUDIA KIMIE SUEMOTO
hcfmusp.contributor.author-fmusphcHELENA PAULA BRENTANI
hcfmusp.contributor.author-fmusphcBENY LAFER
hcfmusp.description.beginpage329
hcfmusp.description.endpage334
hcfmusp.description.volume164
hcfmusp.origemWOS
hcfmusp.origem.pubmed37393798
hcfmusp.origem.scopus2-s2.0-85163497755
hcfmusp.origem.wosWOS:001031995700001
hcfmusp.publisher.cityOXFORDeng
hcfmusp.publisher.countryENGLANDeng
hcfmusp.relation.referenceAl Shweiki MHDR, 2020, TRANSL PSYCHIAT, V10, DOI 10.1038/s41398-020-0825-7eng
hcfmusp.relation.referenceAlhenawi E, 2022, COMPUT BIOL MED, V140, DOI 10.1016/j.compbiomed.2021.105051eng
hcfmusp.relation.referenceBerk M, 2011, NEUROSCI BIOBEHAV R, V35, P804, DOI 10.1016/j.neubiorev.2010.10.001eng
hcfmusp.relation.referenceBigos KL, 2010, ARCH GEN PSYCHIAT, V67, P939, DOI 10.1001/archgenpsychiatry.2010.96eng
hcfmusp.relation.referenceBolstad BM, 2003, BIOINFORMATICS, V19, P185, DOI 10.1093/bioinformatics/19.2.185eng
hcfmusp.relation.referenceBrietzke E, 2010, BIPOLAR DISORD, V12, P453, DOI 10.1111/j.1399-5618.2010.00822.xeng
hcfmusp.relation.referenceCerimele JM, 2017, J CLIN PSYCHIAT, V78, pE506, DOI 10.4088/JCP.16r10897eng
hcfmusp.relation.referenceChe Y, 2010, J PSYCHIATR NEUROSCI, V35, P296, DOI 10.1503/jpn.090083eng
hcfmusp.relation.referenceChen C, 2014, BIPOLAR DISORD, V16, P790, DOI 10.1111/bdi.12255eng
hcfmusp.relation.referenceChepenik LG, 2012, BIOL PSYCHOL, V90, P18, DOI 10.1016/j.biopsycho.2012.01.008eng
hcfmusp.relation.referenceChoi J, 2021, J PSYCHIATR RES, V142, P328, DOI 10.1016/j.jpsychires.2021.08.011eng
hcfmusp.relation.referenceCohen-Mansfield J, 2013, INT J AGING HUM DEV, V77, P37, DOI 10.2190/AG.77.1.ceng
hcfmusp.relation.referenceConejero I, 2018, CLIN INTERV AGING, V13, P691, DOI 10.2147/CIA.S130670eng
hcfmusp.relation.referenceCoon H, 2013, TRANSL PSYCHIAT, V3, DOI 10.1038/tp.2013.100eng
hcfmusp.relation.referencede Oliveira KC, 2012, CELL TISSUE BANK, V13, P315, DOI 10.1007/s10561-011-9258-0eng
hcfmusp.relation.referenceDu XH, 2022, ENVIRON INT, V163, DOI 10.1016/j.envint.2022.107242eng
hcfmusp.relation.referenceFerrer I, 2008, CELL TISSUE BANK, V9, P181, DOI 10.1007/s10561-008-9077-0eng
hcfmusp.relation.referenceFrey BN, 2007, BEHAV PHARMACOL, V18, P419, DOI 10.1097/FBP.0b013e3282df3cdeeng
hcfmusp.relation.referenceGigante AD, 2011, INT J NEUROPSYCHOPH, V14, P1075, DOI 10.1017/S146114571000146Xeng
hcfmusp.relation.referenceGrewal S, 2023, AUST NZ J PSYCHIAT, V57, P328, DOI 10.1177/00048674221091731eng
hcfmusp.relation.referenceHarrison PJ, 2020, MOL PSYCHIATR, V25, P1787, DOI 10.1038/s41380-018-0213-3eng
hcfmusp.relation.referenceKarayannis T, 2014, NATURE, V511, P236, DOI 10.1038/nature13248eng
hcfmusp.relation.referenceKessing LV, 2004, ACTA PSYCHIAT SCAND, V109, P339, DOI 10.1046/j.1600-0447.2003.00266.xeng
hcfmusp.relation.referenceKim HK, 2019, J PSYCHIATR RES, V110, P38, DOI 10.1016/j.jpsychires.2018.12.007eng
hcfmusp.relation.referenceKim HK, 2018, J PSYCHIATR RES, V99, P39, DOI 10.1016/j.jpsychires.2018.01.011eng
hcfmusp.relation.referenceKim HK, 2016, J PSYCHIATR RES, V72, P43, DOI 10.1016/j.jpsychires.2015.10.015eng
hcfmusp.relation.referenceKim HK, 2014, J PSYCHIATR NEUROSCI, V39, P276, DOI 10.1503/jpn.130155eng
hcfmusp.relation.referenceKupka R, 2021, BIPOLAR DISORD, V23, P659, DOI 10.1111/bdi.13105eng
hcfmusp.relation.referenceLanz TA, 2019, TRANSL PSYCHIAT, V9, DOI 10.1038/s41398-019-0492-8eng
hcfmusp.relation.referenceLeirer DJ, 2019, SCHIZOPHR RES, V209, P88, DOI 10.1016/j.schres.2019.05.011eng
hcfmusp.relation.referenceLi ZF, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0202167eng
hcfmusp.relation.referenceLiguori I, 2018, CLIN INTERV AGING, V13, P757, DOI 10.2147/CIA.S158513eng
hcfmusp.relation.referenceNascimento C, 2020, BRAIN BEHAV IMMUN, V90, P286, DOI 10.1016/j.bbi.2020.08.034eng
hcfmusp.relation.referenceNovick DM, 2010, BIPOLAR DISORD, V12, P1, DOI 10.1111/j.1399-5618.2009.00786.xeng
hcfmusp.relation.referencePark SW, 2022, TRANSL PSYCHIAT, V12, DOI 10.1038/s41398-022-01944-8eng
hcfmusp.relation.referencePhillips ML, 2014, AM J PSYCHIAT, V171, P829, DOI 10.1176/appi.ajp.2014.13081008eng
hcfmusp.relation.referenceRen R., 2017, ONCOTARGETeng
hcfmusp.relation.referenceSadeghi I, 2022, COMPUT STRUCT BIOTEC, V20, P4549, DOI 10.1016/j.csbj.2022.08.037eng
hcfmusp.relation.referenceSafran M., 2021, PRACTICAL GUIDE LIFE, P27, DOI 10.1007/978-981-16-5812-9_2eng
hcfmusp.relation.referenceSajatovic M, 2019, BIPOLAR DISORD, V21, P642, DOI 10.1111/bdi.12795eng
hcfmusp.relation.referenceSajatovic M, 2013, NEUROPSYCHIATRY-LOND, V3, P621, DOI 10.2217/npy.13.78eng
hcfmusp.relation.referenceScarr E, 2019, AUST NZ J PSYCHIAT, V53, P1189, DOI 10.1177/0004867419857808eng
hcfmusp.relation.referenceSuemoto CK, 2017, PLOS MED, V14, DOI 10.1371/journal.pmed.1002267eng
hcfmusp.relation.referenceTakao K, 2015, P NATL ACAD SCI USA, V112, P1167, DOI 10.1073/pnas.1401965111eng
hcfmusp.relation.referenceToma C, 2020, JAMA NETW OPEN, V3, DOI 10.1001/jamanetworkopen.2020.3382eng
hcfmusp.relation.referenceValnegri P, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-01333-6eng
hcfmusp.relation.referenceWhiteford HA, 2013, LANCET, V382, P1575, DOI 10.1016/S0140-6736(13)61611-6eng
hcfmusp.relation.referenceXie PX, 2013, BIOL PSYCHIAT, V74, P656, DOI 10.1016/j.biopsych.2013.04.013eng
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