Kinin B1 receptor deficiency attenuates cisplatin-induced acute kidney injury by modulating immune cell migration

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorESTRELA, Gabriel R.
dc.contributor.authorWASINSKI, Frederick
dc.contributor.authorALMEIDA, Danilo C.
dc.contributor.authorAMANO, Mariane T.
dc.contributor.authorCASTOLDI, Angela
dc.contributor.authorDIAS, Carolina C.
dc.contributor.authorMALHEIROS, Denise M. A. C.
dc.contributor.authorALMEIDA, Sandro S.
dc.contributor.authorPAREDES-GAMERO, Edgar J.
dc.contributor.authorPESQUERO, Joao B.
dc.contributor.authorBARROS, Carlos C.
dc.contributor.authorCAMARA, Niels O. S.
dc.contributor.authorARAUJO, Ronaldo C.
dc.date.accessioned2015-02-06T19:47:54Z
dc.date.available2015-02-06T19:47:54Z
dc.date.issued2014
dc.description.abstractCisplatin is a chemotherapeutic agent that causes severe renal dysfunction. The kinin B1 receptor has been associated with the migration of immune cells to injured tissue as well as with renal inflammation. To examine the role of the kinin B1 receptor in cisplatin-induced acute kidney injury, we used kinin B1 receptor knockout mice and treatment with a receptor antagonist before and after cisplatin administration. Cisplatin injection caused exacerbation of renal macrophage and neutrophil migration, higher levels of serum creatinine and blood urea, upregulation of B1 receptor mRNA and an increase in pro-inflammatory cytokines expression. B1 receptor knockout mice exhibited a reduction in serum creatinine and blood urea levels, diminished apoptosis, and decreased cisplatin-induced upregulation of inflammatory components. Moreover, treatment with the B1 receptor antagonist prior to cisplatin administration normalized serum creatinine, blood urea levels, protected from acute tubular necrosis, apoptosis-related genes, and prevented upregulation of pro-inflammatory cytokines. Thus, we propose that kinins have an important role in cisplatin-induced acute kidney injury by impairing immune cells migration to renal tissue during cisplatin nephrotoxicity. <UnorderedList Mark=""Bullet""> <ItemContent> <Para>Kinin B1 receptor is upregulated after cisplatin exposure. Kinin B1 receptor deficiency diminishes the nephrotoxicity caused by cisplatin. Kinin B1 receptor deficiency ameliorates the inflammatory response. Kinin B1 receptor deficiency diminishes apoptosis caused by cisplatin. Kinin B1 receptor antagonism ameliorates renal function after cisplatin injection.
dc.description.indexMEDLINE
dc.description.sponsorshipFAPESP (Fundacao de Apoio a Pesquisa do Estado de Sao Paulo) [2011/03528-0]
dc.identifier.citationJOURNAL OF MOLECULAR MEDICINE-JMM, v.92, n.4, p.399-409, 2014
dc.identifier.doi10.1007/s00109-013-1116-z
dc.identifier.eissn1432-1440
dc.identifier.issn0946-2716
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/8643
dc.language.isoeng
dc.publisherSPRINGER
dc.relation.ispartofJournal of Molecular Medicine-Jmm
dc.rightsrestrictedAccess
dc.rights.holderCopyright SPRINGER
dc.subjectKinins
dc.subjectNephrotoxicity
dc.subjectCisplatin
dc.subjectAcute kidney
dc.subjectinjury
dc.subjectInflammation
dc.subject.otheracute-renal-failure
dc.subject.otherischemia-reperfusion injury
dc.subject.otherchemotactic activity
dc.subject.otherrelease neutrophil
dc.subject.otherdendritic cells
dc.subject.otherbradykinin b1
dc.subject.otherb-1 receptor
dc.subject.othermice
dc.subject.otherexpression
dc.subject.othernephrotoxicity
dc.subject.wosGenetics & Heredity
dc.subject.wosMedicine, Research & Experimental
dc.titleKinin B1 receptor deficiency attenuates cisplatin-induced acute kidney injury by modulating immune cell migration
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalESTRELA, Gabriel R.:Univ Fed Sao Paulo, Dept Biofis, BR-04023062 Sao Paulo, Brazil; Univ Fed Sao Paulo, Disciplina Nefrol, Dept Med, BR-04023062 Sao Paulo, Brazil
hcfmusp.author.externalWASINSKI, Frederick:Univ Fed Sao Paulo, Dept Biofis, BR-04023062 Sao Paulo, Brazil; Univ Fed Sao Paulo, Disciplina Nefrol, Dept Med, BR-04023062 Sao Paulo, Brazil
hcfmusp.author.externalALMEIDA, Danilo C.:Univ Fed Sao Paulo, Disciplina Nefrol, Dept Med, BR-04023062 Sao Paulo, Brazil
hcfmusp.author.externalAMANO, Mariane T.:Univ Sao Paulo, Inst Ciencias Biomed, Dept Imunol, BR-05508 Sao Paulo, Brazil
hcfmusp.author.externalCASTOLDI, Angela:Univ Sao Paulo, Inst Ciencias Biomed, Dept Imunol, BR-05508 Sao Paulo, Brazil
hcfmusp.author.externalDIAS, Carolina C.:Univ Fed Sao Paulo, Dept Biofis, BR-04023062 Sao Paulo, Brazil
hcfmusp.author.externalALMEIDA, Sandro S.:Univ Fed Sao Paulo, Dept Biofis, BR-04023062 Sao Paulo, Brazil
hcfmusp.author.externalPAREDES-GAMERO, Edgar J.:Univ Fed Sao Paulo, Dept Biofis, BR-04023062 Sao Paulo, Brazil
hcfmusp.author.externalPESQUERO, Joao B.:Univ Fed Sao Paulo, Dept Biofis, BR-04023062 Sao Paulo, Brazil
hcfmusp.author.externalBARROS, Carlos C.:Univ Fed Sao Paulo, Dept Nutr, Escola Nutr, BR-04023062 Sao Paulo, Brazil
hcfmusp.author.externalCAMARA, Niels O. S.:Univ Sao Paulo, Inst Ciencias Biomed, Dept Imunol, BR-05508 Sao Paulo, Brazil
hcfmusp.author.externalARAUJO, Ronaldo C.:Univ Fed Sao Paulo, Dept Biofis, BR-04023062 Sao Paulo, Brazil; Univ Fed Sao Paulo, Dept Biophys, BR-04023062 Sao Paulo, Brazil
hcfmusp.citation.scopus16
hcfmusp.contributor.author-fmusphcDENISE MARIA AVANCINI COSTA MALHEIROS
hcfmusp.description.beginpage399
hcfmusp.description.endpage409
hcfmusp.description.issue4
hcfmusp.description.volume92
hcfmusp.origemWOS
hcfmusp.origem.scopus2-s2.0-84898409721
hcfmusp.origem.wosWOS:000334269200009
hcfmusp.publisher.cityNEW YORK
hcfmusp.publisher.countryUSA
hcfmusp.relation.referenceAHLUWALIA A, 1994, EUR J PHARMACOL, V264, P407, DOI 10.1016/0014-2999(94)00503-6
hcfmusp.relation.referenceAraujo RC, 2006, BIOL CHEM, V387, P431, DOI 10.1515/BC.2006.057
hcfmusp.relation.referenceAraujo RC, 2001, BIOL CHEM, V382, P91, DOI 10.1515/BC.2001.014
hcfmusp.relation.referenceBarros CC, 2012, LAB INVEST, V92, P1419, DOI 10.1038/labinvest.2012.105
hcfmusp.relation.referenceDong X, 2007, KIDNEY INT, V71, P619, DOI 10.1038/sj.ki.5002132
hcfmusp.relation.referenceDRAY A, 1993, TRENDS NEUROSCI, V16, P99, DOI 10.1016/0166-2236(93)90133-7
hcfmusp.relation.referenceDuchene J, 2009, CURR OPIN PHARMACOL, V9, P125, DOI 10.1016/j.coph.2008.11.011
hcfmusp.relation.referenceFaubel S, 2007, J PHARMACOL EXP THER, V322, P8, DOI 10.1124/jpet.107.119792
hcfmusp.relation.referenceFerreira J, 2002, NEUROPHARMACOLOGY, V43, P1188, DOI 10.1016/S0028-3908(02)00311-8
hcfmusp.relation.referenceKim HR, 2011, NEPHROLOGY, V16, P545, DOI 10.1111/j.1440-1797.2011.01473.x
hcfmusp.relation.referenceKimura A, 2012, KIDNEY INT, V82, P1093, DOI 10.1038/ki.2012.240
hcfmusp.relation.referenceKlein J, 2009, FASEB J, V23, P134, DOI 10.1096/fj.08-115600
hcfmusp.relation.referenceKlein J, 2010, J AM SOC NEPHROL, V21, P1157, DOI 10.1681/ASN.2009090887
hcfmusp.relation.referenceKoyama S, 2000, AM J RESP CELL MOL, V22, P75
hcfmusp.relation.referenceLi L, 2008, KIDNEY INT, V74, P1526, DOI 10.1038/ki.2008.500
hcfmusp.relation.referenceLim SK, 2012, LIFE SCI, V91, P895, DOI 10.1016/j.lfs.2012.07.020
hcfmusp.relation.referenceLu LH, 2008, J PHARMACOL EXP THER, V324, P111, DOI 10.1124/jpet.107.130161
hcfmusp.relation.referenceMarceau F, 1998, CLIN REV ALLERG IMMU, V16, P385, DOI 10.1007/BF02737658
hcfmusp.relation.referenceMarceau F, 1998, PHARMACOL REV, V50, P357
hcfmusp.relation.referenceMcLean PG, 2000, J EXP MED, V192, P367, DOI 10.1084/jem.192.3.367
hcfmusp.relation.referenceMiller RP, 2010, TOXINS, V2, P2490, DOI 10.3390/toxins2112490
hcfmusp.relation.referenceOkusa MD, 2002, NEPHRON, V90, P133, DOI 10.1159/000049032
hcfmusp.relation.referencePereira RL, 2011, KIDNEY INT, V79, P1217, DOI 10.1038/ki.2011.14
hcfmusp.relation.referencePERRETTI M, 1993, AGENTS ACTIONS, V38, pC64, DOI 10.1007/BF01991139
hcfmusp.relation.referencePesquero JB, 2000, P NATL ACAD SCI USA, V97, P8140, DOI 10.1073/pnas.120035997
hcfmusp.relation.referenceRamesh G, 2002, J CLIN INVEST, V110, P835, DOI 10.1172/JCI200215606
hcfmusp.relation.referenceRamesh G, 2003, AM J PHYSIOL-RENAL, V285, pF610, DOI 10.1152/ajprenal.00101.2003
hcfmusp.relation.referenceRamesh G, 2004, KIDNEY INT, V65, P490, DOI 10.1111/j.1523-1755.2004.00413.x
hcfmusp.relation.referenceREGOLI D, 1980, PHARMACOL REV, V32, P1
hcfmusp.relation.referenceSato E, 1996, J IMMUNOL, V157, P3122
hcfmusp.relation.referenceTadagavadi RK, 2010, J AM SOC NEPHROL, V21, P53, DOI 10.1681/ASN.2009040407
hcfmusp.relation.referenceWang P, 2008, INT J CLIN EXP MED, V1, P1
hcfmusp.relation.referenceWang PHM, 2006, INT IMMUNOPHARMACOL, V6, P1960, DOI 10.1016/j.intimp.2006.07.031
hcfmusp.relation.referenceWang PHM, 2009, INT IMMUNOPHARMACOL, V9, P653, DOI 10.1016/j.intimp.2008.10.018
hcfmusp.relation.referenceWestermann D, 2008, BIOL CHEM, V389, P713, DOI 10.1515/BC.2008.070
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