Correlation between cardiovascular autonomic control dysfunction and oxidative stress in an experimental model of hypertensive and menopause submitted to fructose overload

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorCONTI, Filipe Fernandes
dc.contributor.authorBRITO, Janaina O.
dc.contributor.authorPALMA, Renata K.
dc.contributor.authorBERNARDES, Nathalia
dc.contributor.authorSANCHES, Iris C.
dc.contributor.authorIRIGOYEN, Maria C.
dc.contributor.authorANGELIS, Katia De
dc.date.accessioned2013-10-11T21:31:49Z
dc.date.available2013-10-11T21:31:49Z
dc.date.issued2013
dc.description.abstractThe aim of this study was to verify the effects of fructose overload in an experimental model of hypertensive and menopause on cardiovascular autonomic control and cardiac oxidative stress. Female SHR rats were divided into (n=8/group): hypertensive (H), hypertensive ovariectomized (HO) and hypertensive ovariectomized submitted to fructose overload (100g/L in drinking water) (FHO). Arterial pressure (AP) signals were directly recorded. Cardiovascular autonomic modulation was evaluated by spectral analysis. Oxidative stress was evaluated by chemiluminescence (CL), total reactive antioxidant potential (TRAP) and redox balance of glutathione (GSH/GSSG) determinations. AP was higher in FHO group (174±4 vs. H: 146±4 HO: 164±5 mmHg) than others groups. FHO group showed reduced vagal tonus (5±3 vs. H: 23±4; HO: 35±7 bpm) and increased sympathetic tonus (91±18 vs. H: 56±11; HO: 60±3 bpm) when compared to other groups. CL was higher in FHO group than other groups. GSH/GSSG was lower in FOH group (8.94±0.80 umol/g) than HO group (13.0±1.4 umol/g). Negative correlation was obtained between VAR-SAP and TRAP (r: –0.71, p≤0.05) and a positive correlation between RMSSD index and GSH/GSSG (r: 0.68, p≤0.05). In conclusion, fructose overload induced impairment in cardiovascular autonomic control associated with increased oxidative stress in hypertensive rats submitted to ovarian hormones deprivation.
dc.description.conferencedateAPR 20-24, 2013
dc.description.conferencelocalBoston - MA, EUA
dc.description.conferencenameJoint Annual Meeting of the ASPET/BPS at Experimental Biology (EB)
dc.description.indexMEDLINE
dc.identifier.citationFASEB JOURNAL, v.27, article ID 1143.10, 1p, 2013
dc.identifier.issn0892-6638
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/3159
dc.language.isoeng
dc.publisherFEDERATION AMER SOC EXP BIOL
dc.relation.ispartofFaseb Journal
dc.rightsrestrictedAccess
dc.rights.holderCopyright FEDERATION AMER SOC EXP BIOL
dc.subject.wosBiochemistry & Molecular Biology
dc.subject.wosBiology
dc.subject.wosCell Biology
dc.titleCorrelation between cardiovascular autonomic control dysfunction and oxidative stress in an experimental model of hypertensive and menopause submitted to fructose overload
dc.typeconferenceObject
dc.type.categorymeeting abstract
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalCONTI, Filipe Fernandes:Nove Julho Univ, Translac Physiol Lab, Sao Paulo, Brazil
hcfmusp.author.externalBRITO, Janaina O.:Nove Julho Univ, Translac Physiol Lab, Sao Paulo, Brazil
hcfmusp.author.externalPALMA, Renata K.:Nove Julho Univ, Translac Physiol Lab, Sao Paulo, Brazil
hcfmusp.author.externalBERNARDES, Nathalia:Nove Julho Univ, Translac Physiol Lab, Sao Paulo, Brazil
hcfmusp.author.externalSANCHES, Iris C.:Nove Julho Univ, Translac Physiol Lab, Sao Paulo, Brazil
hcfmusp.author.externalANGELIS, Katia De:Nove Julho Univ, Translac Physiol Lab, Sao Paulo, Brazil
hcfmusp.contributor.author-fmusphcMARIA CLAUDIA COSTA IRIGOYEN
hcfmusp.description.volume27
hcfmusp.origemWOS
hcfmusp.origem.wosWOS:000319860501130
hcfmusp.publisher.cityBETHESDA
hcfmusp.publisher.countryUSA
relation.isAuthorOfPublication124821b6-302b-4392-8a9a-b693916724e1
relation.isAuthorOfPublication.latestForDiscovery124821b6-302b-4392-8a9a-b693916724e1
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