The effects of zoledronic acid and dexamethasone on osseointegration of endosseous implants: histological and histomorphometrical evaluation in rats

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorOLIVEIRA, Marcio A. de
dc.contributor.authorASAHI, Denise A.
dc.contributor.authorSILVEIRA, Celey A. E.
dc.contributor.authorLIMA, Luiz Antonio P. A.
dc.contributor.authorGLICK, Michael
dc.contributor.authorGALLOTTINI, Marina
dc.date.accessioned2015-07-01T20:35:02Z
dc.date.available2015-07-01T20:35:02Z
dc.date.issued2015
dc.description.abstractBackgroundBisphosphonates are a widely used class of drugs that prevent bone loss. Several side effects related to bisphosphonate therapy have been reported, including osteonecrosis of the jaws associated with invasive dental procedures and implants placement. ObjectivesTo evaluate the influence of intravenous nitrogen-containing BPs in combination with or without dexamethasone on osseointegration of titanium implants placed in an animal model. MethodsTwenty-seven male Wistar rats were divided into three groups: group 1 was treated solely with zoledronic acid, group 2 was treated with zoledronic acid and dexamethasone, and group 3 did only receive saline solution injections. Two endosseous implants were placed in each tibia, and three animals from each group were sacrificed at postoperative times of seven, 14, and 28days. Non-decalcified sections were observed with light microscopy for histological and histomorphometrical analyses. ResultsHistomorphometrical analysis using the animals and the implants as unit of measurement revealed no statistically significant difference regarding bone-implant contact and bone density among the three groups. Histological observation revealed that zoledronic acid-treated animals in combination with or without dexamethasone showed expressive less bone remodeling activity at 14 and 28days after implants placement, compared with control specimens. ConclusionsThe studied bisphosphonate regimens did not interfere with the osseointegration of the implants, cortical, or medular bone deposition, but a possible lack of bone remodeling of the original cortical bone may affect long-term osseointegration.
dc.description.indexMEDLINE
dc.identifier.citationCLINICAL ORAL IMPLANTS RESEARCH, v.26, n.4, p.e17-e21, 2015
dc.identifier.doi10.1111/clr.12335
dc.identifier.eissn1600-0501
dc.identifier.issn0905-7161
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/9510
dc.language.isoeng
dc.publisherWILEY-BLACKWELL
dc.relation.ispartofClinical Oral Implants Research
dc.rightsrestrictedAccess
dc.rights.holderCopyright WILEY-BLACKWELL
dc.subjectanimal model
dc.subjectbisphosphonates
dc.subjectendosseous implants
dc.subject.otherbisphosphonate-related osteonecrosis
dc.subject.otherdental implants
dc.subject.otherbone
dc.subject.otherjaw
dc.subject.otherosteoporosis
dc.subject.otherglucocorticoids
dc.subject.otherextractions
dc.subject.otheralendronate
dc.subject.othernecrosis
dc.subject.othertherapy
dc.subject.wosDentistry, Oral Surgery & Medicine
dc.subject.wosEngineering, Biomedical
dc.titleThe effects of zoledronic acid and dexamethasone on osseointegration of endosseous implants: histological and histomorphometrical evaluation in rats
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.affiliation.countryEstados Unidos
hcfmusp.affiliation.countryisous
hcfmusp.author.externalOLIVEIRA, Marcio A. de:Univ Sao Paulo, Sch Dent, Dept Stomatol, BR-05508000 Sao Paulo, Brazil
hcfmusp.author.externalASAHI, Denise A.:Univ Sao Paulo, Sch Dent, Dept Stomatol, BR-05508000 Sao Paulo, Brazil
hcfmusp.author.externalLIMA, Luiz Antonio P. A.:Univ Sao Paulo, Sch Dent, Dept Stomatol, BR-05508000 Sao Paulo, Brazil
hcfmusp.author.externalGLICK, Michael:SUNY Buffalo, Sch Dent, Dept Oral Med, Buffalo, NY 14260 USA
hcfmusp.author.externalGALLOTTINI, Marina:Univ Sao Paulo, Sch Dent, Dept Stomatol, BR-05508000 Sao Paulo, Brazil
hcfmusp.citation.scopus15
hcfmusp.contributor.author-fmusphcCELEY APARECIDA EUGENIO SILVEIRA CASADIO
hcfmusp.description.beginpagee17
hcfmusp.description.endpagee21
hcfmusp.description.issue4
hcfmusp.description.volume26
hcfmusp.origemWOS
hcfmusp.origem.pubmed24438459
hcfmusp.origem.scopus2-s2.0-84924246610
hcfmusp.origem.wosWOS:000350755400003
hcfmusp.publisher.cityHOBOKEN
hcfmusp.publisher.countryUSA
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