Choroidal Thickness in Eyes with Band Atrophy of the Optic Nerve from Chiasmal Compression

Imagem de Miniatura
Arquivos
art_MELLO_Choroidal_Thickness_in_Eyes_with_Band_Atrophy_of_2022.PDF (1.32 MB)
Citações na Scopus
2
Tipo de produção
article
Data de publicação
2022
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
HINDAWI LTD
Autores
Citação
JOURNAL OF OPHTHALMOLOGY, v.2022, article ID 5625803, 6p, 2022
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Background. The choroid is a vascular tissue that helps maintain retinal and prelaminar optic nerve head function. Choroidal thickness has been previously studied in diseases accompanied by retinal neural loss, but the relationship between the two sets of measurements is not clear. In eyes with temporal hemianopia as a result of chiasmal compression lesions (CCL), retinal neural loss tends to be greater in the nasal than the temporal hemiretina, a fact that may be useful in evaluating the effect of inner retinal layer loss on choroidal thickness. Purpose. To evaluate macular and peripapillary choroidal thickness on swept-source optical coherence tomography (SS-OCT) in eyes with temporal hemianopia as a result of chiasmal compression and in healthy controls. Methods. 33 eyes of 26 patients with band atrophy of the optic nerve and temporal visual field defects as a result of previously treated suprasellar tumors (CCL group) and 40 eyes of 21 healthy controls underwent SS-OCT scanning. The thickness of the peripapillary retinal nerve fiber layer (pRNFL), the peripapillary choroid (pChoroid), the macular RNFL (mRNFL), the macular ganglion cell layer (mGCL), and the macular choroid (mChoroid) was expressed globally and by sector (peripapillary quadrants and macular hemifield and quadrants). Ratios between macular nasal and temporal hemifield and quadrantic measurements were calculated using generalized estimated equation models, and the two groups were compared. Results. The pRNFL, mRNFL, and mGCC thicknesses were significantly smaller in the CCL group than in the control group (64.67 +/- 10.53 mu m, 29.68 & nbsp;+/- 5.80 mu m, and 80.60 & nbsp;+/- 10.17 mu m vs. 103.78 & nbsp;+/- 12.23 mu m, 39.89 & nbsp;+/- 3.82 mu m, and 105.51 +/-& nbsp;7.76 mu m, respectively; p < 0.001). For the choroid, the only difference between the groups was increased macular nasal hemifield and superonasal quadrant thickness in CCL (222.47 & nbsp;+/- 61.05 mu m and 230.45 +/- 58.59 mu m in the CCL group, respectively vs. 190.68 & nbsp;+/- 52.54 mu m and 197.65 & nbsp;+/- 54.80 mu m in the control group, respectively; p < 0.05). The temporal/nasal ratios were significantly higher for the mRNFL and mGCC parameters and significantly lower for the mChoroid parameters in the CCL group, except for the superotemporal/superonasal quadrant ratio. Conclusions. The choroid does not thin after the inner retinal layer becomes damaged due to CCL and may even be thicker in some areas with corresponding severe retinal neural loss. While further studies are needed to interpret these findings, choroidal thinning is most likely not secondary to optic nerve disease-related inner retinal neural loss.
Palavras-chave
URI
https://observatorio.fm.usp.br/handle/OPI/47169
Referências
  1. Abdellatif MK, 2019, J OPHTHALMOL, V2019, DOI 10.1155/2019/1698967
  2. Abdolrahimzadeh S, 2016, RETINA-J RET VIT DIS, V36, P2329, DOI 10.1097/IAE.0000000000001097
  3. Borrelli E, 2016, SCI REP-UK, V6, DOI 10.1038/srep37332
  4. Cunha LP, 2008, DOC OPHTHALMOL, V117, P223, DOI 10.1007/s10633-008-9126-9
  5. Cunha LP, 2009, ARQ BRAS OFTALMOL, V72, P622, DOI 10.1590/S0004-27492009000500004
  6. Darvizeh F, 2020, EYE, V34, P1624, DOI 10.1038/s41433-019-0695-5
  7. de Araujo RB, 2017, FRONT NEUROL, V8, DOI 10.3389/fneur.2017.00619
  8. Di Staso F, 2019, IN VIVO, V33, P1403, DOI 10.21873/invivo.11617
  9. Ehrlich JR, 2011, EXP EYE RES, V92, P189, DOI 10.1016/j.exer.2011.01.002
  10. Eraslan M, 2016, ACTA OPHTHALMOL, V94, pE68, DOI 10.1111/aos.12809
  11. Ferreira CS, 2017, RETINA-J RET VIT DIS, V37, P529, DOI 10.1097/IAE.0000000000001193
  12. HAYREH SS, 1969, BRIT J OPHTHALMOL, V53, P721, DOI 10.1136/bjo.53.11.721
  13. HAYREH SS, 1990, EYE, V4, P273, DOI 10.1038/eye.1990.39
  14. Hayreh SS, 2001, PROG RETIN EYE RES, V20, P563, DOI 10.1016/S1350-9462(01)00004-0
  15. Hirooka K, 2012, CLIN EXP OPHTHALMOL, V40, P576, DOI 10.1111/j.1442-9071.2012.02762.x
  16. Lee JY, 2017, CURR EYE RES, V42, P1628, DOI 10.1080/02713683.2017.1358374
  17. Lee KM, 2016, ACTA OPHTHALMOL, V94, pE697, DOI 10.1111/aos.13086
  18. Li L, 2013, AM J OPHTHALMOL, V156, P1277, DOI 10.1016/j.ajo.2013.07.011
  19. Maul EA, 2011, OPHTHALMOLOGY, V118, P1571, DOI 10.1016/j.ophtha.2011.01.016
  20. Mrejen S, 2013, SURV OPHTHALMOL, V58, P387, DOI 10.1016/j.survophthal.2012.12.001
  21. Mukherjee C, 2019, THER ADV OPHTHALMOL, V11, DOI 10.1177/2515841419831155
  22. Mwanza JC, 2011, INVEST OPHTH VIS SCI, V52, P3430, DOI 10.1167/iovs.10-6600
  23. Park JH, 2018, MEDICINE, V97, DOI 10.1097/MD.0000000000011001
  24. Suzuki ACF, 2020, EYE, V34, P695, DOI 10.1038/s41433-019-0564-2
  25. UNSOLD R, 1980, ARCH OPHTHALMOL-CHIC, V98, P1637, DOI 10.1001/archopht.1980.01020040489020

Coleções
Artigos e Materiais de Revistas Científicas - FM/MOF
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/33