Seroprevalence of Zika in Brazil stratified by age and geographic distribution

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Citações na Scopus
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Tipo de produção
article
Data de publicação
2023
Título da Revista
ISSN da Revista
Título do Volume
Editora
CAMBRIDGE UNIV PRESS
Autores
BOTOSSO, Viviane Fongaro
PRECIOSO, Alexander Roberto
WILDER-SMITH, Annelies
OLIVEIRA, Danielle Bruna Leal de
OLIVEIRA, Fabyano Bruno Leal de
OLIVEIRA, Cairo Monteiro De
SOARES, Camila Pereira
OLIVEIRA, Lucyana Trindade Leal
SANTO, Ralyria Mello Vieira dos
UTESCHER, Carla Lilian de Agostini
Citação
EPIDEMIOLOGY AND INFECTION, v.151, article ID e197, 7p, 2023
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Congenital Zika is a devastating consequence of maternal Zika virus infections. Estimates of age-dependent seroprevalence profiles are central to our understanding of the force of Zika virus infections. We set out to calculate the age-dependent seroprevalence of Zika virus infections in Brazil. We analyzed serum samples stratified by age and geographic location, collected from 2016 to 2019, from about 16,000 volunteers enrolled in a Phase 3 dengue vaccine trial led by the Institute Butantan in Brazil. Our results show that Zika seroprevalence has a remarkable age-dependent and geographical distribution, with an average age of the first infection varying from region to region, ranging from 4.97 (3.03-5.41) to 7.24 (6.98-7.90) years. The calculated basic reproduction number, $ {R}_0 $, varied from region to region, ranging from 1.18 (1.04-1.41) to 2.33 (1.54-3.85). Such data are paramount to determine the optimal age to vaccinate against Zika, if and when such a vaccine becomes available.
Palavras-chave
arboviruses, emerging infections, epidemiology, mathematical modelling, Zika virus
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