Validation of an algorithmic nutritional approach in children undergoing chemotherapy for cancer

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorTOTADRI, Sidharth
dc.contributor.authorTREHAN, Annita
dc.contributor.authorMAHAJAN, Diviyaa
dc.contributor.authorVIANI, Karina
dc.contributor.authorBARR, Ronald
dc.contributor.authorLADAS, Elena J.
dc.date.accessioned2020-03-24T14:55:09Z
dc.date.available2020-03-24T14:55:09Z
dc.date.issued2019
dc.description.abstractBackground Undernutrition impacts clinical outcome adversely in children with cancer. This study aimed to validate a nutritional algorithm with specific application to the low- and middle-income country (LMIC) setting. Procedure Fifty children with a new diagnosis of cancer were enrolled in this randomized interventional study. Weight, height/length, and mid-upper-arm circumference (MUAC) were measured at baseline. The study arm was administered nutritional care as per the algorithm and the control arm received the institutional standard of care. Weight was monitored regularly and MUAC was repeated after 3 months. Children were classified based on weight for height if <2 years of age or body mass index if >= 2 years, as normal, wasted, and severely wasted. The algorithmic approach comprised administration of oral supplements, nasogastric feeds, and/or parenteral nutrition based on objective assessment of the nutritional status. Results Fifty patients were analyzed (study: 25, control: 25). Four in the study arm (16%) and six in the control arm (24%) had wasting at baseline. MUAC was <5th percentile in 15 (60%) and 13 (52%) patients in the study and control arms, respectively. At the end of 3 months, the median increment in weight was 0.8 kg (interquartile range [IQR]: -0.02; 2.00) and 0.0 kg (IQR: -0.70; 1.25) in the study and control arms, respectively (P = .153). The median increment in MUAC was 1.20 cm (IQR: 0.10; 2.30) and 0.00 cm (IQR: -0.50; 1.10) in the study and control arms, respectively (P = .020). Conclusions The application of an algorithm designed for use in LMICs resulted in significant improvement in nutritional status, as measured by MUAC.eng
dc.description.indexMEDLINEeng
dc.identifier.citationPEDIATRIC BLOOD & CANCER, v.66, n.12, article ID e27980, 6p, 2019
dc.identifier.doi10.1002/pbc.27980
dc.identifier.eissn1545-5017
dc.identifier.issn1545-5009
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/35653
dc.language.isoeng
dc.publisherWILEYeng
dc.relation.ispartofPediatric Blood & Cancer
dc.rightsrestrictedAccesseng
dc.rights.holderCopyright WILEYeng
dc.subjectdeveloping countryeng
dc.subjectmid-arm circumferenceeng
dc.subjectpediatric oncologyeng
dc.subjectsurvival gapeng
dc.subjectundernutritioneng
dc.subject.otherpediatric oncologyeng
dc.subject.wosOncologyeng
dc.subject.wosHematologyeng
dc.subject.wosPediatricseng
dc.titleValidation of an algorithmic nutritional approach in children undergoing chemotherapy for cancereng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.affiliation.countryEstados Unidos
hcfmusp.affiliation.countryCanadá
hcfmusp.affiliation.countryÍndia
hcfmusp.affiliation.countryisoin
hcfmusp.affiliation.countryisoca
hcfmusp.affiliation.countryisous
hcfmusp.author.externalTOTADRI, Sidharth:Postgrad Inst Med Educ & Res, Adv Pediat Ctr, Dept Pediat, Pediat Hematol Oncol Unit, Chandigarh 160012, India
hcfmusp.author.externalTREHAN, Annita:Postgrad Inst Med Educ & Res, Adv Pediat Ctr, Dept Pediat, Pediat Hematol Oncol Unit, Chandigarh 160012, India
hcfmusp.author.externalMAHAJAN, Diviyaa:Postgrad Inst Med Educ & Res, Adv Pediat Ctr, Dept Pediat, Pediat Hematol Oncol Unit, Chandigarh 160012, India
hcfmusp.author.externalBARR, Ronald:McMaster Childrens Hosp, Dept Pediat, Hamilton, ON, Canada; McMaster Childrens Hosp, Dept Pathol, Hamilton, ON, Canada; McMaster Childrens Hosp, Dept Med, Hamilton, ON, Canada
hcfmusp.author.externalLADAS, Elena J.:Columbia Univ, Med Ctr, Div Pediat Hematol Oncol Stem Cell Transplant, New York, NY USA
hcfmusp.citation.scopus19
hcfmusp.contributor.author-fmusphcKARINA HELENA CANTON VIANI
hcfmusp.description.articlenumbere27980
hcfmusp.description.issue12
hcfmusp.description.volume66
hcfmusp.origemWOS
hcfmusp.origem.pubmed31464100
hcfmusp.origem.scopus2-s2.0-85071566742
hcfmusp.origem.wosWOS:000484105400001
hcfmusp.publisher.cityHOBOKENeng
hcfmusp.publisher.countryUSAeng
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