IL28B Gene Polymorphism SNP rs8099917 Genotype GG Is Associated with HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) in HTLV-1 Carriers

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorASSONE, Tatiane
dc.contributor.authorSOUZA, Fernando Vieira de
dc.contributor.authorGAESTER, Karen Oliveira
dc.contributor.authorFONSECA, Luiz Augusto Marcondes
dc.contributor.authorLUIZ, Olinda do Carmo
dc.contributor.authorMALTA, Fernanda
dc.contributor.authorPINHO, Joao Renato Rebello
dc.contributor.authorGONCALVES, Fernanda de Toledo
dc.contributor.authorDUARTE, Alberto Jose da Silva
dc.contributor.authorOLIVEIRA, Augusto Cesar Penalva de
dc.contributor.authorCASSEB, Jorge
dc.date.accessioned2015-02-06T19:47:49Z
dc.date.available2015-02-06T19:47:49Z
dc.date.issued2014
dc.description.abstractBackground: The polymorphisms of IL28B have been described as important in the pathogenesis of infections caused by some viruses. The aim of this research was to evaluate whether IL28B gene polymorphisms (SNP rs8099917 and SNP rs12979860) are associated with HAM/TSP. Methods: The study included 229 subjects, classified according to their neurological status in two groups: Group I (136 asymptomatic HTLV-1 carriers) and Group II (93 HAM/TSP patients). The proviral loads were quantified, and the rs8099917 and rs12979860 SNPs in the region of IL28B-gene were analyzed by StepOnePlus Real-time PCR System. Results: A multivariate model analysis, including gender, age, and HTLV-1 DNA proviral load, showed that IL28B polymorphisms were independently associated with HAM/TSP outcome in rs12979860 genotype CT (OR = 2.03; IC95% = 0.96-4.27) and in rs8099917 genotype GG (OR = 7.61; IC95% = 1.82-31.72). Conclusion: Subjects with SNP rs8099917 genotype GG and rs12979618 genotype CT may present a distinct immune response against HTLV-1 infection. So, it seems reasonable to suggest that a search for IL28B polymorphisms should be performed for all HTLV-1-infected subjects in order to monitor their risk for disease development; however, since this is the first description of such finding in the literature, we should first replicate this study with more HTLV-1-infected persons to strengthen the evidence already provided by our results.
dc.description.indexMEDLINE
dc.description.sponsorshipCNPq [134001/2011-7]
dc.description.sponsorshipFAPESP [2010/07076-4, 2012/23397-0]
dc.identifier.citationPLOS NEGLECTED TROPICAL DISEASES, v.8, n.9, article ID e3199, 5p, 2014
dc.identifier.doi10.1371/journal.pntd.0003199
dc.identifier.issn1935-2735
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/8617
dc.language.isoeng
dc.publisherPUBLIC LIBRARY SCIENCE
dc.relation.ispartofPlos Neglected Tropical Diseases
dc.rightsopenAccess
dc.rights.holderCopyright PUBLIC LIBRARY SCIENCE
dc.subject.otherhepatitis-c virus
dc.subject.othert-cell leukemia
dc.subject.otheri proviral load
dc.subject.otherinfection
dc.subject.otheroutcomes
dc.subject.othermarkers
dc.subject.othertype-1
dc.subject.wosInfectious Diseases
dc.subject.wosParasitology
dc.subject.wosTropical Medicine
dc.titleIL28B Gene Polymorphism SNP rs8099917 Genotype GG Is Associated with HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) in HTLV-1 Carriers
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalSOUZA, Fernando Vieira de:Inst Doencas Infecciosas Emilio Ribas IIER Sao Pa, Sao Paulo, Brazil
hcfmusp.author.externalOLIVEIRA, Augusto Cesar Penalva de:Inst Doencas Infecciosas Emilio Ribas IIER Sao Pa, Sao Paulo, Brazil
hcfmusp.citation.scopus26
hcfmusp.contributor.author-fmusphcTATIANE ASSONE CASSEB
hcfmusp.contributor.author-fmusphcKAREN ELIANE DE OLIVEIRA GAESTER
hcfmusp.contributor.author-fmusphcLUIZ AUGUSTO MARCONDES FONSECA
hcfmusp.contributor.author-fmusphcOLINDA DO CARMO LUIZ
hcfmusp.contributor.author-fmusphcFERNANDA DE MELLO MALTA
hcfmusp.contributor.author-fmusphcJOAO RENATO REBELLO PINHO
hcfmusp.contributor.author-fmusphcFERNANDA DE TOLEDO GONCALVES
hcfmusp.contributor.author-fmusphcALBERTO JOSE DA SILVA DUARTE
hcfmusp.contributor.author-fmusphcJORGE SIMAO DO ROSARIO CASSEB
hcfmusp.description.articlenumbere3199
hcfmusp.description.issue9
hcfmusp.description.volume8
hcfmusp.origemWOS
hcfmusp.origem.scopus2-s2.0-84907584290
hcfmusp.origem.wosWOS:000342796600067
hcfmusp.publisher.citySAN FRANCISCO
hcfmusp.publisher.countryUSA
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