Longitudinal changes in blood pressure are preceded by changes in albuminuria and accelerated by increasing dietary sodium intake

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorKATAYAMA, Isis Akemi
dc.contributor.authorHUANG, Yuefei
dc.contributor.authorGARZA, Amanda E.
dc.contributor.authorBROOKS, Danielle L.
dc.contributor.authorWILLIAMS, Jonathan S.
dc.contributor.authorNASCIMENTO, Mariana M.
dc.contributor.authorHEIMANN, Joel C.
dc.contributor.authorPOJOGA, Luminita H.
dc.date.accessioned2023-06-21T14:06:22Z
dc.date.available2023-06-21T14:06:22Z
dc.date.issued2023
dc.description.abstractBackground: Dietary sodium is a well-known risk factor for cardiovascular and renal disease; however, direct evidence of the longitudinal changes that occur with aging, and the influence of dietary sodium on the age-associated alterations are scarce. Methods: C57BL/6 mice were maintained for 13 months on a low (LS, 0.02 % Na+), normal (NS, 0.3 % Na+) or high (HS, 1.6 % Na+) salt diet. We assessed 1) the longitudinal trajectories for two markers of cardiovascular and renal dysfunction (blood pressure (BP) and albuminuria), as well as hormonal changes, and 2) end-of-study cardiac and renal parameters. Results: The effect of aging on BP and kidney damage did not reach significance levels in the LS group; however, relative to baseline, there were significant increases in these parameters for animals maintained on NS and HS diets, starting as early as month 7 and month 5, respectively. Furthermore, changes in albuminuria preceded the changes in BP relative to baseline, irrespective of the diet. Circulating aldosterone and plasma renin activity displayed the expected decreasing trends with age and dietary sodium loading. As compared to LS - higher dietary sodium consumption associated with increasing trends in left ventricular mass and volume indices, consistent with an eccentric dilated phenotype. Functional and molecular markers of kidney dysfunction dis-played similar trends with increasing long-term sodium levels: higher renovascular resistance, increased glomerular volumes, as well as higher levels of renal angiotensin II type 1 and mineralocorticoid receptors, and lower renal Klotho levels. Conclusion: Our study provides a timeline for the development of cardiorenal dysfunction with aging, and doc-uments that increasing dietary salt accelerates the age-induced phenotypes. In addition, we propose albuminuria as a prognostic biomarker for the future development of hypertension. Last, we identified functional and mo-lecular markers of renal dysfunction that associate with long-term dietary salt loading.eng
dc.description.indexMEDLINE
dc.description.indexPubMed
dc.description.indexWoS
dc.description.indexScopus
dc.description.sponsorshipNIH [T32HL007609, R01HL127146, R01HL104032]
dc.description.sponsorshipNational Heart, Lung, and Blood Institute [14GRNT20500000]
dc.description.sponsorshipAmerican Heart Association [6752-14-4, 2016/14696-5]
dc.description.sponsorshipFunda?a?o de Amparo a` Pesquisa do Estado de Sa?o Paulo
dc.identifier.citationEXPERIMENTAL GERONTOLOGY, v.173, article ID 112114, 10p, 2023
dc.identifier.doi10.1016/j.exger.2023.112114
dc.identifier.eissn1873-6815
dc.identifier.issn0531-5565
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/53814
dc.language.isoeng
dc.publisherPERGAMON-ELSEVIER SCIENCE LTDeng
dc.relation.ispartofExperimental Gerontology
dc.rightsrestrictedAccesseng
dc.rights.holderCopyright PERGAMON-ELSEVIER SCIENCE LTDeng
dc.subjectDietary sodiumeng
dc.subjectBlood pressureeng
dc.subjectAgingeng
dc.subjectAlbuminuriaeng
dc.subject.otherage-related-changeseng
dc.subject.otherrenin-angiotensin systemeng
dc.subject.othermodest salt reductioneng
dc.subject.otherklotho geneeng
dc.subject.othervascular contractioneng
dc.subject.othermolecular-mechanismseng
dc.subject.otherresistive indexeng
dc.subject.otherhypertensioneng
dc.subject.othermiceeng
dc.subject.otherhypertrophyeng
dc.subject.wosGeriatrics & Gerontologyeng
dc.titleLongitudinal changes in blood pressure are preceded by changes in albuminuria and accelerated by increasing dietary sodium intakeeng
dc.typearticleeng
dc.type.categoryrevieweng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.affiliation.countryEstados Unidos
hcfmusp.affiliation.countryisous
hcfmusp.author.externalKATAYAMA, Isis Akemi:Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Div Endocrinol Diabet & Hypertens, Boston, MA USA; Univ Sao Paulo, Sch Med, Dept Internal Med, Lab Expt Hypertens, Sao Paulo, Brazil
hcfmusp.author.externalHUANG, Yuefei:Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Div Endocrinol Diabet & Hypertens, Boston, MA USA; NCI, Ctr Canc Res, Surg Branch, Bethesda, MD USA
hcfmusp.author.externalGARZA, Amanda E.:Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Div Endocrinol Diabet & Hypertens, Boston, MA USA
hcfmusp.author.externalBROOKS, Danielle L.:Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Div Endocrinol Diabet & Hypertens, Boston, MA USA
hcfmusp.author.externalWILLIAMS, Jonathan S.:Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Div Endocrinol Diabet & Hypertens, Boston, MA USA
hcfmusp.author.externalNASCIMENTO, Mariana M.:Univ Sao Paulo, Sch Med, Dept Internal Med, Lab Expt Hypertens, Sao Paulo, Brazil
hcfmusp.author.externalPOJOGA, Luminita H.:Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Div Endocrinol Diabet & Hypertens, Boston, MA USA; Brigham & Womens Hosp, Div Endocrinol Diabet & Hypertens, 221 Longwood Ave, Boston, MA 02115 USA
hcfmusp.citation.scopus0
hcfmusp.contributor.author-fmusphcJOEL CLAUDIO HEIMANN
hcfmusp.description.articlenumber112114
hcfmusp.description.volume173
hcfmusp.origemWOS
hcfmusp.origem.pubmed36738979
hcfmusp.origem.scopus2-s2.0-85147833569
hcfmusp.origem.wosWOS:000963972000001
hcfmusp.publisher.cityOXFORDeng
hcfmusp.publisher.countryENGLANDeng
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