Immunohistochemical Evidence for Myofibroblast-like Cells Associated with Liver Injury Induced by Aflatoxin B1 in Rainbow Trout (Oncorhynchus mykiss)

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorARANA, S.
dc.contributor.authorALVES, V. A. F.
dc.contributor.authorSABINO, M.
dc.contributor.authorTABATA, Y. A.
dc.contributor.authorNONOGAKI, S.
dc.contributor.authorZAIDAN-DAGLI, M. -L.
dc.contributor.authorHERNANDEZ-BAZQUEZ, F. J.
dc.date.accessioned2014-09-30T14:45:21Z
dc.date.available2014-09-30T14:45:21Z
dc.date.issued2014
dc.description.abstractIn mammalian species, profibrogenic cells are activated to become myofibroblasts in response to liver damage. Few studies have examined hepatic myofibroblasts and their role in liver damage in teleosts. The aim of the present study was to investigate the involvement of myofibroblast-like cells in rainbow trout (Oncorhynchus mykiss) with hepatic damage induced by aflatoxin B1 (AFB1). Histopathological and immunohistochemical analyses characterized alterations in the liver stroma during the carcinogenic process. Anti-human a-smooth muscle actin (SMA) and anti-human desmin primary antibodies were used in immunohistochemistry. Only the anti-SMA reagent labelled cells in. trout liver. In the livers of control fish, only smooth muscle in blood vessels and around bile ducts was labelled. In the livers from AFB1-treated fish, SMA-positive cells were present in the stroma surrounding neoplastic lesions and in areas of desmoplastic reaction. These observations indicate that in teleosts, as in mammals, the myofibroblast-like cell is involved in fibrosis associated with liver injury. Chronic liver injury induced in trout by aflatoxin may provide a useful model system for study of the evolution of such mechanisms.
dc.description.indexMEDLINE
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
dc.description.sponsorshipFundo de Apoio ao Ensino, Pesquisa e Extensao da Universidade Estadual de Campinas (Faepex/Unicamp)
dc.identifier.citationJOURNAL OF COMPARATIVE PATHOLOGY, v.150, n.2-3, p.258-265, 2014
dc.identifier.doi10.1016/j.jcpa.2013.07.003
dc.identifier.eissn1532-3129
dc.identifier.issn0021-9975
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/7702
dc.language.isoeng
dc.publisherELSEVIER SCI LTD
dc.relation.ispartofJournal of Comparative Pathology
dc.rightsrestrictedAccess
dc.rights.holderCopyright ELSEVIER SCI LTD
dc.subjectfish
dc.subjecthepatocarcinogenesis
dc.subjectliver fibrosis
dc.subjectmyofibroblast
dc.subject.otherhepatocellular-carcinoma cells
dc.subject.othermedaka oryzias-latipes
dc.subject.otherhepatic stellate cells
dc.subject.otherfat-storing cells
dc.subject.otherfish model
dc.subject.otherito-cells
dc.subject.otherfibrosis
dc.subject.otherexpression
dc.subject.othercirrhosis
dc.subject.otherlesions
dc.subject.wosPathology
dc.subject.wosVeterinary Sciences
dc.titleImmunohistochemical Evidence for Myofibroblast-like Cells Associated with Liver Injury Induced by Aflatoxin B1 in Rainbow Trout (Oncorhynchus mykiss)
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalARANA, S.:Univ Estadual Campinas, UNICAMP, Inst Biol, Dept Histol & Embryol, BR-13083970 Sao Paulo, Brazil
hcfmusp.author.externalSABINO, M.:Adolfo Lutz Inst, Sao Paulo, Brazil
hcfmusp.author.externalTABATA, Y. A.:Secretaria Agr & Abastecimento Sao Paulo, APTA, Estacao Expt Salmonicultura Dr Ascanio de Faria, Sao Paulo, Brazil
hcfmusp.author.externalNONOGAKI, S.:Adolfo Lutz Inst, Sao Paulo, Brazil
hcfmusp.author.externalZAIDAN-DAGLI, M. -L.:Univ Sao Paulo, Sch Vet Med & Anim Sci, Dept Pathol, Sao Paulo, Brazil
hcfmusp.author.externalHERNANDEZ-BAZQUEZ, F. J.:Univ Sao Paulo, Sch Vet Med & Anim Sci, Dept Surg, Sao Paulo, Brazil
hcfmusp.citation.scopus16
hcfmusp.contributor.author-fmusphcVENANCIO AVANCINI FERREIRA ALVES
hcfmusp.description.beginpage258
hcfmusp.description.endpage265
hcfmusp.description.issue2-3
hcfmusp.description.volume150
hcfmusp.origemWOS
hcfmusp.origem.pubmed24016778
hcfmusp.origem.scopus2-s2.0-84895871661
hcfmusp.origem.wosWOS:000334141500019
hcfmusp.publisher.cityOXFORD
hcfmusp.publisher.countryENGLAND
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hcfmusp.remissive.sponsorshipCNPq
hcfmusp.remissive.sponsorshipFAPESP
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