Prenatal exposure to Cannabis smoke induces early and lasting damage to the brain

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorBENEVENUTO, Sarah G. M.
dc.contributor.authorDOMENICO, Marlise D.
dc.contributor.authorYARIWAKE, Victor Y.
dc.contributor.authorDIAS, Clarissa Tavares
dc.contributor.authorMENDES-DA-SILVA, Cristiano
dc.contributor.authorALVES, Nilmara de O.
dc.contributor.authorCAUMO, Sofia Ellen da S.
dc.contributor.authorVASCONCELLOS, Perola
dc.contributor.authorMORAIS, Damila R.
dc.contributor.authorCARDOSO, Marilia S.
dc.contributor.authorIANICELLI, Janaina
dc.contributor.authorWAKED, Dunia
dc.contributor.authorDAVEY, Gavin P.
dc.contributor.authorBOYLAN, Fabio
dc.contributor.authorCOSTA, Jose L.
dc.contributor.authorVERAS, Mariana Matera
dc.date.accessioned2022-12-21T13:33:37Z
dc.date.available2022-12-21T13:33:37Z
dc.date.issued2022
dc.description.abstractCannabis is the most widely used illegal drug during pregnancy, however, the effects of gestational exposure to Cannabis smoke (CS) on the central nervous system development remain uncharacterised. This study investigates the effects of maternal CS inhalation on brain function in the offspring. Pregnant mice were exposed daily to 5 min of CS during gestational days (GD) 5.5-17.5. On GD 18.5 half of the dams were euthanized for foetus removal. The offspring from the remaining dams were euthanized on postnatal days (PND) 20 and 60 for evaluation. Brain volume, cortex cell number, SOX2, histone-H3, parvalbumin, NeuN, and BDNF immunoreac-tivity were assessed in all groups. In addition, levels of NeuN, CB1 receptor, and BDNF expression were assessed and cortical primary neurons from rats were treated with Cannabis smoke extract (CSE) for assessment of cell viability. We found that male foetuses from the CS exposed group had decreased brain volume, whereas mice at PND 60 from the exposed group presented with increased brain volume. Olfactory bulb and diencephalon vol-ume were found lower in foetuses exposed to CS. Mice at PND 60 from the exposed group had a smaller volume in the thalamus and hypothalamus while the cerebellum presented with a greater volume. Also, there was an increase in cortical BDNF immunoreactivity in CS exposed mice at PND 60. Protein expression analysis showed an increase in pro-BDNF in foetus brains exposed to CS. Mice at PND 60 presented an increase in mature BDNF in the prefrontal cortex (PFC) in the exposed group and a higher CB1 receptor expression in the PFC. Moreover, hippocampal NeuN expression was higher in adult animals from the exposed group. Lastly, treatment of cortical primary neurons with doses of CSE resulted in decreased cell viability. These findings highlight the potential negative neurodevelopmental outcomes induced by gestational CS exposure.eng
dc.description.indexMEDLINEeng
dc.identifier.citationNEUROCHEMISTRY INTERNATIONAL, v.160, article ID 105406, 15p, 2022
dc.identifier.doi10.1016/j.neuint.2022.105406
dc.identifier.eissn1872-9754
dc.identifier.issn0197-0186
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/50908
dc.language.isoeng
dc.publisherPERGAMON-ELSEVIER SCIENCE LTDeng
dc.relation.ispartofNeurochemistry International
dc.rightsrestrictedAccesseng
dc.rights.holderCopyright PERGAMON-ELSEVIER SCIENCE LTDeng
dc.subjectCannabinoidseng
dc.subjectGestationeng
dc.subjectBrain developmenteng
dc.subjectNeuroneng
dc.subjectCannabis smoke extracteng
dc.subject.otherpolycyclic aromatic-hydrocarbonseng
dc.subject.othermarijuana smokeeng
dc.subject.otherneurotrophic factoreng
dc.subject.othercb1 receptorseng
dc.subject.otherendocannabinoid systemeng
dc.subject.othercognitive-developmenteng
dc.subject.otherneuronal developmenteng
dc.subject.othersubventricular zoneeng
dc.subject.otherperinatal exposureeng
dc.subject.otheradult ratseng
dc.subject.wosBiochemistry & Molecular Biologyeng
dc.subject.wosNeuroscienceseng
dc.titlePrenatal exposure to Cannabis smoke induces early and lasting damage to the braineng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.affiliation.countryIrlanda
hcfmusp.affiliation.countryFrança
hcfmusp.affiliation.countryisofr
hcfmusp.affiliation.countryisoie
hcfmusp.author.externalDOMENICO, Marlise D.:Univ Sao Paulo, Sch Med, Dept Pathol, Lab Expt Air Pollut, Sao Paulo, Brazil
hcfmusp.author.externalDIAS, Clarissa Tavares:Univ Fed Sao Paulo, Dept Biosci, Lab Neurosci & Nutr, UNIFESP, Santos, SP, Brazil
hcfmusp.author.externalMENDES-DA-SILVA, Cristiano:Univ Fed Sao Paulo, Dept Biosci, Lab Neurosci & Nutr, UNIFESP, Santos, SP, Brazil
hcfmusp.author.externalALVES, Nilmara de O.:Univ Sao Paulo, Sch Med, Dept Pathol, Lab Expt Air Pollut, Sao Paulo, Brazil; Univ Lille, Inserm, U1003, F-59000 Lille, France
hcfmusp.author.externalCAUMO, Sofia Ellen da S.:Univ Sao Paulo, Inst Chem, Sao Paulo, Brazil
hcfmusp.author.externalVASCONCELLOS, Perola:Univ Sao Paulo, Inst Chem, Sao Paulo, Brazil; Sergio Arouca Natl Sch Publ Hlth, Oswaldo Cruz Fdn, Rio De Janeiro, RJ, Brazil
hcfmusp.author.externalMORAIS, Damila R.:Shimadzu Brazil, Barueri, SP, Brazil
hcfmusp.author.externalCARDOSO, Marilia S.:Univ Estadual Campinas, Fac Med Sci, Campinas Poison Control Ctr, Campinas, SP, Brazil
hcfmusp.author.externalDAVEY, Gavin P.:Trinity Biomed Sci Inst, Trinity Coll Dublin, Sch Biochem & Immunol, Dublin, Ireland
hcfmusp.author.externalBOYLAN, Fabio:Trinity Biomed Sci Inst, Trinity Coll Dublin, Sch Pharm & Pharmaceut Sci, Dublin, Ireland
hcfmusp.author.externalCOSTA, Jose L.:Univ Estadual Campinas, Fac Pharmaceut Sci, Campinas, SP, Brazil
hcfmusp.citation.scopus1
hcfmusp.contributor.author-fmusphcSARAH GOMES DE MENEZES BENEVENUTO
hcfmusp.contributor.author-fmusphcVICTOR YUJI YARIWAKE
hcfmusp.contributor.author-fmusphcJANAINA IANNICELLI TORRES
hcfmusp.contributor.author-fmusphcDUNIA WAKED
hcfmusp.contributor.author-fmusphcMARIANA MATERA VERAS
hcfmusp.description.articlenumber105406
hcfmusp.description.volume160
hcfmusp.origemWOS
hcfmusp.origem.pubmed35970295
hcfmusp.origem.scopus2-s2.0-85136109599
hcfmusp.origem.wosWOS:000848578600001
hcfmusp.publisher.cityOXFORDeng
hcfmusp.publisher.countryENGLANDeng
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