Biomechanical Analysis of Tissue Engineering Construct for Articular Cartilage Restoration-A Pre-clinical Study

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorFARIA, R. R. de
dc.contributor.authorMAIZATO, M. J. S.
dc.contributor.authorCESTARI, I. A.
dc.contributor.authorHERNANDEZ, A. J.
dc.contributor.authorBUENO, D. F.
dc.contributor.authorBORTOLUSSI, R.
dc.contributor.authorALBUQUERQUE, C.
dc.contributor.authorFERNANDES, T. L.
dc.date.accessioned2022-11-25T13:46:26Z
dc.date.available2022-11-25T13:46:26Z
dc.date.issued2022
dc.description.abstractThe chondral lesion and osteoarthritis are conditions associated with an economic burden, since if left untreated may cause changes in the biomechanics of the joint and result in several injuries considered highly disabling to the individual. Mesenchymal Stem Cells (MSCs) have the immunomodulatory capacity and paracrine signaling that are useful for tissue bioengineering to treat bone and cartilage injuries. To the best of our knowledge, there is no institution in Brazil studying cartilage biomechanical properties in Good Manufacturing Practice (GMP) technique. Therefore, this study aims to describe biomechanics analysis for cartilage restoration by tissue engineering and cell therapy treatments in a GMP translational large animal model. A controlled experimental study in fourteen Brazilian miniature pigs was performed, using scaffold-free Tissue Engineering Construct (TEC) from dental pulp and synovial MSCs with 6 months follow-up. To compare the cartilage with and without TEC, indentation and maximum compressive tests were performed, as well as Finite Element model to simulate the osteochondral block and characterize its properties. The Young's Modulus of each sample was determined, and the outcomes of maximum compressive test demonstrated the cartilage integrity. The proposed method was feasible and capable to properly evaluate articular cartilage restoration.eng
dc.description.conferencedateOCT 26-30, 2020
dc.description.conferencelocalELECTR NETWORK
dc.description.conferencename27th Brazilian Congress on Biomedical Engineering (CBEB)
dc.description.indexPubMedeng
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2017/05774-5]
dc.description.sponsorshipCoordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES) [88881.171651/2018-01]
dc.description.sponsorshipInternational Society of Arthroscopy, Knee Surgery and Orthopaedic Sports Medicine
dc.description.sponsorshipOrthopaedic Research and Education Foundation (ISAKOS Osteoarthritis Grant-2018)
dc.identifier.citationXXVII BRAZILIAN CONGRESS ON BIOMEDICAL ENGINEERING, CBEB 2020, p.133-137, 2022
dc.identifier.doi10.1007/978-3-030-70601-2_22
dc.identifier.isbn978-3-030-70601-2; 978-3-030-70600-5
dc.identifier.issn1680-0737
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/50256
dc.language.isoeng
dc.publisherSPRINGEReng
dc.relation.ispartofXxvii Brazilian Congress on Biomedical Engineering, Cbeb 2020
dc.relation.ispartofseriesIFMBE Proceedings
dc.rightsrestrictedAccesseng
dc.rights.holderCopyright SPRINGEReng
dc.subjectMechanical testingeng
dc.subjectBiomechanicseng
dc.subjectIndentation testeng
dc.subjectCell therapyeng
dc.subjectMesenchymal Stem Cellseng
dc.subjectArticular cartilageeng
dc.subject.othermechanical-propertieseng
dc.subject.otherosteoarthritiseng
dc.subject.otherindentationeng
dc.subject.othermethodologyeng
dc.subject.othergenerationeng
dc.subject.otherdefectseng
dc.subject.otherkneeeng
dc.subject.wosEngineering, Biomedicaleng
dc.titleBiomechanical Analysis of Tissue Engineering Construct for Articular Cartilage Restoration-A Pre-clinical Studyeng
dc.typeconferenceObjecteng
dc.type.categoryproceedings papereng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.author.externalFARIA, R. R. de:Univ Sao Paulo, Fac Med, Hosp Clin, Inst Orthoped & Traumatol, 333 Dr Ovidio Pires de Campos, BR-05403010 Sao Paulo, SP, Brazil; Pontificia Univ Catolica Sao Paulo PUC SP, Sao Paulo, SP, Brazil
hcfmusp.author.externalBUENO, D. F.:Hosp Sirio Libanes, Sao Paulo, SP, Brazil
hcfmusp.author.externalBORTOLUSSI, R.:Ctr Univ FEI, Sao Paulo, Brazil
hcfmusp.author.externalALBUQUERQUE, C.:Ctr Univ FEI, Sao Paulo, Brazil
hcfmusp.citation.scopus0
hcfmusp.contributor.author-fmusphcMARINA JUNKO SHIOTSU MAIZATO
hcfmusp.contributor.author-fmusphcIDAGENE APARECIDA CESTARI
hcfmusp.contributor.author-fmusphcARNALDO JOSE HERNANDEZ
hcfmusp.contributor.author-fmusphcTIAGO LAZZARETTI FERNANDES
hcfmusp.description.beginpage133
hcfmusp.description.endpage137
hcfmusp.origemWOS
hcfmusp.origem.scopus2-s2.0-85128956674
hcfmusp.origem.wosWOS:000871993700025
hcfmusp.publisher.cityNEW YORKeng
hcfmusp.publisher.countryUNITED STATESeng
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hcfmusp.scopus.lastupdate2024-05-18
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