Dietary fat intake modifies the influence of the FTO rs9939609 polymorphism on adiposity in adolescents: The HELENA cross-sectional study

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorLABAYEN, I.
dc.contributor.authorRUIZ, J. R.
dc.contributor.authorHUYBRECHTS, I.
dc.contributor.authorORTEGA, F. B.
dc.contributor.authorARENAZA, L.
dc.contributor.authorGONZALEZ-GROSS, M.
dc.contributor.authorWIDHALM, K.
dc.contributor.authorMOLNAR, D.
dc.contributor.authorMANIOS, Y.
dc.contributor.authorDEHENAUW, S.
dc.contributor.authorMEIRHAEGHE, A.
dc.contributor.authorMORENO, L. A.
dc.date.accessioned2016-12-20T16:42:38Z
dc.date.available2016-12-20T16:42:38Z
dc.date.issued2016
dc.description.abstractBackground and aims: The fat mass and obesity associated gene (FTO) has been associated with obesity and dietary intake. The aims were: (i) To assess whether energy and macro-nutrient intakes were different across the FTOrs9939609 genotypes in adolescents, and (ii) to explore whether dietary fat intake modified the association of the rs9939609 polymorphism with adiposity. Methods and results: The FTOrs9939609 polymorphism was genotyped in 652 adolescents (53% females, 14.8 +/- 1.2 years, TT = 246, TA = 296, AA = 110). Energy and macronutrient intake were assessed by two non-consecutive 24 h-recalls. Weight, height, waist circumference and skinfold thicknesses were measured and body fat percent was calculated. Energy and macronutrient intake were similar across the FTOrs9939609 genotypes (P > 0.2). There were significant interactions between the FTO polymorphism and fat intake on adiposity estimates (P < 0.05). In adolescents whose fat intake was below 30% (N =203), the A allele of rs9939609 was not associated with adiposity indices. In contrast, in adolescents whose fat intake was between 30% and 35% of energy (N = 190), the rs9939609 polymorphismwas associated with a 1.9% higher body fat per risk allele (95% CI: 0.39, 3.33; P < 0.05), and in those whose fat intake was higher than 35% (N =259), it was associated with a 2.8% higher body fat per risk allele (95% CI: 1.27, 4.43; P < 0.001). Conclusions: These findings support the concept that the deleterious effect of the FTOrs9939609 polymorphism on adiposity is exacerbated in adolescents consuming high fat diets. In contrast, the consumption of low fat diets (< 30% of energy) may attenuate the genetic predisposition to obesity in risk allele carriers.
dc.description.indexMEDLINE
dc.description.sponsorshipEuropean Community Sixth RTD Framework Programme [FOOD-CT-2005-007034]
dc.description.sponsorshipSpanish Ministry of Science and Innovation [RYC-2010-05957, RYC-2011-09011]
dc.description.sponsorshipUniversity of the Basque Country [GIU14/21]
dc.description.sponsorshipSpanish Ministry of Health (CIBERobn) [CB12/03/30038]
dc.identifier.citationNUTRITION METABOLISM AND CARDIOVASCULAR DISEASES, v.26, n.10, p.937-943, 2016
dc.identifier.doi10.1016/j.numecd.2016.07.010
dc.identifier.eissn1590-3729
dc.identifier.issn0939-4753
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/17208
dc.language.isoeng
dc.publisherELSEVIER SCI LTD
dc.relation.ispartofNutrition Metabolism and Cardiovascular Diseases
dc.rightsrestrictedAccess
dc.rights.holderCopyright ELSEVIER SCI LTD
dc.subjectFTO gene
dc.subjectDiet composition
dc.subjectFat intake
dc.subjectObesity
dc.subjectAdolescents
dc.subject.otherbody-mass index
dc.subject.otherfinnish diabetes prevention
dc.subject.otherbasal metabolic-rate
dc.subject.otherphysical-activity
dc.subject.otherenergy-intake
dc.subject.othergoldberg cutoff
dc.subject.othermacronutrient intake
dc.subject.othervariant rs9939609
dc.subject.othergenetic-variants
dc.subject.otherchildren
dc.subject.wosCardiac & Cardiovascular Systems
dc.subject.wosEndocrinology & Metabolism
dc.subject.wosNutrition & Dietetics
dc.titleDietary fat intake modifies the influence of the FTO rs9939609 polymorphism on adiposity in adolescents: The HELENA cross-sectional study
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.affiliation.countryFrança
hcfmusp.affiliation.countryisoes
hcfmusp.affiliation.countryisofr
hcfmusp.affiliation.countryisoat
hcfmusp.affiliation.countryisohu
hcfmusp.affiliation.countryisogr
hcfmusp.affiliation.countryisobe
hcfmusp.author.externalLABAYEN, I.:Univ Basque Country, UPV EHU, Dept Nutr & Food Sci, Vitoria, Spain; Univ Basque Country, UPV EHU, Nutr Exercise & Hlth Res Grp, Elikadura Ariketa Fisikoa & Osasuna,ELIKOS Grp, Vitoria, Spain
hcfmusp.author.externalRUIZ, J. R.:Univ Granada, Fac Sport Sci, Dept Phys Educ & Sport, Granada, Spain
hcfmusp.author.externalHUYBRECHTS, I.:Univ Ghent, Dept Publ Hlth, Ghent, Belgium; Int Agcy Res Canc, Dietary Exposure Assessment Grp, Lyon, France
hcfmusp.author.externalORTEGA, F. B.:Univ Granada, Fac Sport Sci, Dept Phys Educ & Sport, Granada, Spain
hcfmusp.author.externalARENAZA, L.:Univ Basque Country, UPV EHU, Dept Nutr & Food Sci, Vitoria, Spain; Univ Basque Country, UPV EHU, Nutr Exercise & Hlth Res Grp, Elikadura Ariketa Fisikoa & Osasuna,ELIKOS Grp, Vitoria, Spain
hcfmusp.author.externalGONZALEZ-GROSS, M.:Univ Politecn Madrid, Fac Phys Act & Sport Sci INEF, Madrid, Spain
hcfmusp.author.externalWIDHALM, K.:Med Univ Vienna, Dept Pediat, Div Nutr & Metab, Vienna, Austria
hcfmusp.author.externalMOLNAR, D.:Univ Pecs, Dept Pediat, Pecs, Hungary
hcfmusp.author.externalMANIOS, Y.:Harokopio Univ, Dept Nutr & Dietet, Athens, Greece
hcfmusp.author.externalDEHENAUW, S.:Univ Ghent, Dept Publ Hlth, Ghent, Belgium
hcfmusp.author.externalMEIRHAEGHE, A.:Univ Lille Nord France, Inst Pasteur Lille, INSERM U1167, Lille, France
hcfmusp.citation.scopus22
hcfmusp.description.beginpage937
hcfmusp.description.endpage943
hcfmusp.description.issue10
hcfmusp.description.volume26
hcfmusp.origemWOS
hcfmusp.origem.pubmed27514607
hcfmusp.origem.scopus2-s2.0-84995480106
hcfmusp.origem.wosWOS:000386831000012
hcfmusp.publisher.cityOXFORD
hcfmusp.publisher.countryENGLAND
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