Micoses superficiais e os elementos da resposta imune*

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorCRIADO, Paulo Ricardo
dc.contributor.authorOLIVEIRA, Cristiane Beatriz de
dc.contributor.authorDANTAS, Katia Cristina
dc.contributor.authorTAKIGUTI, Filomena Amaro
dc.contributor.authorBENINI, Luciana Vasconcellos
dc.contributor.authorVASCONCELLOS, Cidia
dc.date.accessioned2017-11-27T16:35:05Z
dc.date.available2017-11-27T16:35:05Z
dc.date.issued2011
dc.description.abstractSuperficial mycoses are prevalent worldwide. They are often caused by dermatophytes and restricted to the stratum corneum. The host's immune response against infections caused by dermatophytes basically depends on the host's defense against metabolites of the fungi, virulence of the infecting strain or species and anatomical site of the infection. We will review some of the factors of the host's immune defense that influence the efficacy of the immune response. We will particularly review the role of pattern recognition receptors (PRRs), such as toll-like receptors or lectin receptors (DCSIGN and Dectin 2), which participate in the innate immune response, bringing specificity to the immune response and setting its pattern. The predominance of a cellular or humoral immune response determines the clinical manifestations and the prognosis of the infection, leading to healing or chronicity. Keywords: Allergy and immunology; Fungi; Inflammation mediators; Integumentary system
dc.description.abstractAs micoses superficiais são prevalentes em todo o mundo, geralmente ocasionadas por dermatófitos e restritas à camada córnea. A resposta imunológica do hospedeiro às infecções dos fungos dermatófitos depende basicamente das defesas do hospedeiro a metabólitos do fungo, da virulência da cepa ou da espécie infectante e da localização anatômica da infecção. Serão revistos alguns dos fatores da defesa imunológica do hospedeiro que influenciam na eficácia da resposta imune. Em especial, a participação dos receptores de padrão de reconhecimento (PRRs), tais como os receptores toll-like ou os da família lectina (DC-SIGN e dectin-2), que participam da resposta imune inata, conferindo-lhe especificidade e definindo o padrão da resposta imune como um todo. O predomínio celular ou humoral da resposta imune definirá o quadro clínico e o prognóstico da infecção, levando à cura ou cronicidade.
dc.description.indexMEDLINE
dc.identifier.citationANAIS BRASILEIROS DE DERMATOLOGIA, v.86, n.4, p.726-731, 2011
dc.identifier.eissn1806-4841
dc.identifier.issn0365-0596
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/23482
dc.language.isoeng
dc.language.isopor
dc.publisherSOC BRASILEIRA DERMATOLOGIA
dc.relation.ispartofAnais Brasileiros de Dermatologia
dc.rightsopenAccess
dc.rights.holderCopyright SOC BRASILEIRA DERMATOLOGIA
dc.subjectAllergy and immunology
dc.subjectFungi
dc.subjectInflammation mediators
dc.subjectIntegumentary system
dc.subjectAlergia e imunologia
dc.subjectFungos
dc.subjectMediadores da inflamação
dc.subjectTegumento comum
dc.subject.othernecrosis-factor-alpha
dc.subject.othertoll-like receptors
dc.subject.otherhuman keratinocytes
dc.subject.otherdendritic cells
dc.subject.otheraspergillus-fumigatus
dc.subject.othercandida-albicans
dc.subject.otherparacoccidioides-brasiliensis
dc.subject.otheracquired-immunity
dc.subject.othermicrosporum-canis
dc.subject.otherepithelial-cells
dc.subject.wosDermatology
dc.titleMicoses superficiais e os elementos da resposta imune*
dc.title.alternativeSuperficial mycosis and the immune response elements
dc.typearticle
dc.type.categoryreview
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.citation.scopus20
hcfmusp.contributor.author-fmusphcPAULO RICARDO CRIADO
hcfmusp.contributor.author-fmusphcCRISTIANE BEATRIZ DE OLIVEIRA
hcfmusp.contributor.author-fmusphcKATIA CRISTINA DANTAS
hcfmusp.contributor.author-fmusphcFILOMENA MARIKO AMARO TAKIGUTI
hcfmusp.contributor.author-fmusphcCIDIA VASCONCELLOS
hcfmusp.description.beginpage726
hcfmusp.description.endpage731
hcfmusp.description.issue4
hcfmusp.description.volume86
hcfmusp.origemWOS
hcfmusp.origem.pubmed21987139
hcfmusp.origem.scopus2-s2.0-80053962762
hcfmusp.origem.wosWOS:000295719800014
hcfmusp.publisher.cityRIO DE JANEIRO RJ
hcfmusp.publisher.countryBRAZIL
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