Moderate/severe erectile dysfunction in patients with antiphospholipid syndrome

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorGALLINARO, A. Lopes
dc.contributor.authorSILVA, C. A.
dc.contributor.authorRABELO JUNIOR, C. N.
dc.contributor.authorCALEIRO, M. T. Correia
dc.contributor.authorCARVALHO, J. F. de
dc.date.accessioned2013-07-30T17:19:24Z
dc.date.available2013-07-30T17:19:24Z
dc.date.issued2012
dc.description.abstractPurpose: To evaluate sexual function of antiphospholipid syndrome (APS) patients using the Brazilian version of the validated International Index of Erectile Function (IIEF). Materials and methods: Eleven APS male patients (Sapporo criteria) were age and race-matched with 22 healthy controls. Demographic and clinical data, drug use and antiphospholipid antibodies were evaluated. The IIEF was also self-applied. Results: Mean age (p = 0.114), frequency of Caucasian race (p = 1.00) and married status (p = 0.438) were similar in APS and controls. Mean disease duration was 8.8 +/- 4.6 years. Erectile dysfunction (ED) was frequently observed in APS versus controls (45.5 vs. 4.5%, p = 0.0096), especially moderate/severe ED (p = 0.0081). The total IIEF score (49.6 vs. 67.1, p = 0.019), erectile function (19.6 vs. 28.1, p = 0.005) and intercourse satisfaction (7.8 vs. 11.9, p = 0.009) were lower in patients than in controls. No differences were seen in orgasmic function (p = 0.114), sexual desire (p = 0.123) or overall satisfaction (p = 0.097) between the groups. The comparison between APS patients with ED (n = 5) and without ED (n = 6) revealed more arterial events in APS with ED (100 vs. 16.7%, p = 0.0152), and also longer disease duration (12 [7-16] vs. 5.5 [2-13] years, p = 0.031). A trend towards lower venous events (20 vs. 83.3%, p = 0.0801) and higher renal thrombotic microangiopathy (60% vs. 0, p = 0.0606) was observed in APS patients with ED. Demographics, clinical manifestations, smoking and antiphospholipid antibodies positivity were similar in both groups. Conclusion: To our knowledge, this was the first study that demonstrated moderate/severe ED in almost 50% of cases of a rare autoimmune disease. This alteration was linked to arterial events and longer disease duration. Lupus (2012) 21, 319-323.
dc.description.indexMEDLINE
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico - CNPQ [300248/2008-3, 300665/2009-1]
dc.description.sponsorshipFederico Foundation
dc.identifier.citationLUPUS, v.21, n.3, p.319-323, 2012
dc.identifier.doi10.1177/0961203311427552
dc.identifier.issn0961-2033
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/1360
dc.language.isoeng
dc.publisherSAGE PUBLICATIONS LTD
dc.relation.ispartofLupus
dc.rightsrestrictedAccess
dc.rights.holderCopyright SAGE PUBLICATIONS LTD
dc.subjectantiphospholipid syndrome
dc.subjecterectile dysfunction
dc.subjectimpotence
dc.subjectInternational Index of Erectile Function (IIEF) Brazilian version
dc.subject.otherankylosing-spondylitis
dc.subject.othermen
dc.subject.otheronset
dc.subject.otherrisk
dc.subject.wosRheumatology
dc.titleModerate/severe erectile dysfunction in patients with antiphospholipid syndrome
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.citation.scopus2
hcfmusp.contributor.author-fmusphcANDREA LOPES GALLINARO
hcfmusp.contributor.author-fmusphcCLOVIS ARTUR ALMEIDA DA SILVA
hcfmusp.contributor.author-fmusphcCARLOS NOBRE RABELO JUNIOR
hcfmusp.contributor.author-fmusphcMARIA TERESA CORREIA CALEIRO
hcfmusp.contributor.author-fmusphcJOZELIO FREIRE DE CARVALHO
hcfmusp.description.beginpage319
hcfmusp.description.endpage323
hcfmusp.description.issue3
hcfmusp.description.volume21
hcfmusp.lim.ref2012
hcfmusp.origemWOS
hcfmusp.origem.pubmed22074844
hcfmusp.origem.scopus2-s2.0-84856780583
hcfmusp.origem.wosWOS:000299847400010
hcfmusp.publisher.cityLONDON
hcfmusp.publisher.countryENGLAND
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hcfmusp.remissive.sponsorshipCNPq
hcfmusp.remissive.sponsorshipFederico Foundation
hcfmusp.remissive.sponsorshipCNPq
hcfmusp.remissive.sponsorshipFederico Foundation
hcfmusp.scopus.lastupdate2024-04-12
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