QUANTIFICATION OF LEFT VENTRICULAR MYOCARDIAL COLLAGEN SYSTEM IN CHILDREN, YOUNG ADULTS, AND THE ELDERLY

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorMENDES, Andrea Bogoslavsky Levy
dc.contributor.authorFERRO, Marcelo
dc.contributor.authorRODRIGUES, Bruno
dc.contributor.authorSOUZA, Monica Rodrigues De
dc.contributor.authorARAUJO, Rubens Correa
dc.contributor.authorSOUZA, Romeu Rodrigues De
dc.date.accessioned2013-10-02T19:33:39Z
dc.date.available2013-10-02T19:33:39Z
dc.date.issued2012
dc.description.abstractStudies on the collagen system of the human myocardium are still limited compared to those on small laboratory animals. The aim of this work was to observe the collagen tissue of the myocardium of the human heart as a function of age. The types of collagen, as well as the density of collagen tissue and the diameter of collagen fibrils, were examined. Fragments of the left ventricular wall from 15 hearts, 5 from children, 5 from young adults, and 5 from elderly individuals, were analyzed by using the Picrosirius-polarization method and by transmission electron microscopy (TEM). The results showed the presence of collagen type III and collagen type I, both in the endomysium and perimysium of the 3 groups studied. Measurements of collagen content in myocardial tissue displayed that both endomysial and perimysial collagen increase in number and thickness in the adult and elderly. These histochemical results coincided with the observations obtained with the electron microscope in showing an increase in the number of collagen fibrils with a large diameter in the adult and elderly hearts. The present results on cardiac collagen may be important for assessing the pathogenesis of several cardiopathies in the hearts of children, young adults, and the elderly.
dc.description.indexMEDLINE
dc.identifier.citationMEDICINA-BUENOS AIRES, v.72, n.3, p.216-220, 2012
dc.identifier.issn0025-7680
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/2583
dc.language.isoeng
dc.publisherMEDICINA (BUENOS AIRES)
dc.relation.ispartofMedicina-Buenos Aires
dc.rightsopenAccess
dc.rights.holderCopyright MEDICINA (BUENOS AIRES)
dc.subjectcollagen fibrils
dc.subjectmorphometry
dc.subjecthuman heart
dc.subjectchildren
dc.subjectyoung adult
dc.subjectelderly
dc.subject.otherpolarization microscopy
dc.subject.otherextracellular-matrix
dc.subject.othertissue-sections
dc.subject.otherrat myocardium
dc.subject.otherheart-failure
dc.subject.otherexpression
dc.subject.otherfibrosis
dc.subject.othergrowth
dc.subject.otherage
dc.subject.otheraldosterone
dc.subject.wosMedicine, General & Internal
dc.titleQUANTIFICATION OF LEFT VENTRICULAR MYOCARDIAL COLLAGEN SYSTEM IN CHILDREN, YOUNG ADULTS, AND THE ELDERLY
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalMENDES, Andrea Bogoslavsky Levy:Univ Sao Judas Tadeu, Human Movement Lab, Sao Paulo, SP, Brazil
hcfmusp.author.externalFERRO, Marcelo:Univ Sao Judas Tadeu, Human Movement Lab, Sao Paulo, SP, Brazil; Univ Sao Paulo, Italo Brazilian Univ Ctr, Sao Paulo, SP, Brazil
hcfmusp.author.externalSOUZA, Monica Rodrigues De:Univ Sao Judas Tadeu, Human Movement Lab, Sao Paulo, SP, Brazil
hcfmusp.author.externalARAUJO, Rubens Correa:Univ Sao Judas Tadeu, Human Movement Lab, Sao Paulo, SP, Brazil
hcfmusp.author.externalSOUZA, Romeu Rodrigues De:Univ Sao Judas Tadeu, Human Movement Lab, Sao Paulo, SP, Brazil
hcfmusp.citation.scopus35
hcfmusp.contributor.author-fmusphcBRUNO RODRIGUES
hcfmusp.description.beginpage216
hcfmusp.description.endpage220
hcfmusp.description.issue3
hcfmusp.description.volume72
hcfmusp.origemWOS
hcfmusp.origem.pubmed22763158
hcfmusp.origem.scieloSCIELO:S0025-76802012000300005
hcfmusp.origem.scopus2-s2.0-84864026073
hcfmusp.origem.wosWOS:000306396900005
hcfmusp.publisher.cityBUENOS AIRES
hcfmusp.publisher.countryARGENTINA
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