The Genomic Ancestry of Individuals from Different Geographical Regions of Brazil Is More Uniform Than Expected

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Citações na Scopus
473
Tipo de produção
article
Data de publicação
2011
DOI
Scopus
Web of Science
PubMed
Título da Revista
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Editora
PUBLIC LIBRARY SCIENCE
Autores
PENA, Sergio D. J.
PIETRO, Giuliano Di
FUCHSHUBER-MORAES, Mateus
GENRO, Julia Pasqualini
HUTZ, Mara H.
KEHDY, Fernanda de Souza Gomes
KOHLRAUSCH, Fabiana
MAGNO, Luiz Alexandre Viana
MONTENEGRO, Raquel Carvalho
MORAES, Manoel Odorico
Citação
PLOS ONE, v.6, n.2, article ID e17063, 9p, 2011
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Based on pre-DNA racial/color methodology, clinical and pharmacological trials have traditionally considered the different geographical regions of Brazil as being very heterogeneous. We wished to ascertain how such diversity of regional color categories correlated with ancestry. Using a panel of 40 validated ancestry-informative insertion-deletion DNA polymorphisms we estimated individually the European, African and Amerindian ancestry components of 934 self-categorized White, Brown or Black Brazilians from the four most populous regions of the Country. We unraveled great ancestral diversity between and within the different regions. Especially, color categories in the northern part of Brazil diverged significantly in their ancestry proportions from their counterparts in the southern part of the Country, indicating that diverse regional semantics were being used in the self-classification as White, Brown or Black. To circumvent these regional subjective differences in color perception, we estimated the general ancestry proportions of each of the four regions in a form independent of color considerations. For that, we multiplied the proportions of a given ancestry in a given color category by the official census information about the proportion of that color category in the specific region, to arrive at a ""total ancestry"" estimate. Once such a calculation was performed, there emerged a much higher level of uniformity than previously expected. In all regions studied, the European ancestry was predominant, with proportions ranging from 60.6% in the Northeast to 77.7% in the South. We propose that the immigration of six million Europeans to Brazil in the 19(th) and 20(th) centuries - a phenomenon described and intended as the ""whitening of Brazil"" -is in large part responsible for dissipating previous ancestry dissimilarities that reflected region-specific population histories. These findings, of both clinical and sociological importance for Brazil, should also be relevant to other countries with ancestrally admixed populations.
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URI
https://observatorio.fm.usp.br/handle/OPI/23419
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MPS