Neutralizing human monoclonal antibodies prevent Zika virus infection in macaques

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorMAGNANI, Diogo M.
dc.contributor.authorROGERS, Thomas F.
dc.contributor.authorBEUTLER, Nathan
dc.contributor.authorRICCIARDI, Michael J.
dc.contributor.authorBAILEY, Varian K.
dc.contributor.authorGONZALEZ-NIETO, Lucas
dc.contributor.authorBRINEY, Bryan
dc.contributor.authorSOK, Devin
dc.contributor.authorLE, Khoa
dc.contributor.authorSTRUBEL, Alexander
dc.contributor.authorGUTMAN, Martin J.
dc.contributor.authorPEDRENO-LOPEZ, Nuria
dc.contributor.authorGRUBAUGH, Nathan D.
dc.contributor.authorSILVEIRA, Cassia G. T.
dc.contributor.authorMAXWELL, Helen S.
dc.contributor.authorDOMINGUES, Aline
dc.contributor.authorMARTINS, Mauricio A.
dc.contributor.authorLEE, David E.
dc.contributor.authorOKWUAZI, Erica E.
dc.contributor.authorJEAN, Sherrie
dc.contributor.authorSTROBERT, Elizabeth A.
dc.contributor.authorCHAHROUDI, Ann
dc.contributor.authorSILVESTRI, Guido
dc.contributor.authorVANDERFORD, Thomas H.
dc.contributor.authorKALLAS, Esper G.
dc.contributor.authorDESROSIERS, Ronald C.
dc.contributor.authorBONALDO, Myrna C.
dc.contributor.authorWHITEHEAD, Stephen S.
dc.contributor.authorBURTON, Dennis R.
dc.contributor.authorWATKINS, David I.
dc.date.accessioned2017-12-12T13:14:23Z
dc.date.available2017-12-12T13:14:23Z
dc.date.issued2017
dc.description.abstractTherapies to prevent maternal Zika virus (ZIKV) infection and its subsequent fetal developmental complications are urgently required. We isolated three potent ZIKV-neutralizing monoclonal antibodies (nmAbs) from the plasma-blasts of a ZIKV-infected patient-SMZAb1, SMZAb2, and SMZAb5-directed against two different domains of the virus. We engineered these nmAbs with Fc LALA mutations that abrogate Fc gamma receptor binding, thus eliminating potential therapy-mediated antibody-dependent enhancement. We administered a cocktail of these three nmAbs to nonhuman primates 1 day before challenge with ZIKV and demonstrated that the nmAbs completely prevented viremia in serum after challenge. Given that numerous antibodies have exceptional safety profiles in humans, the cocktail described here could be rapidly developed to protect uninfected pregnant women and their fetuses.
dc.description.indexMEDLINE
dc.description.sponsorshipNIH [4P01AI094420-05, P30AI073961, P51 OD011132]
dc.description.sponsorshipWallace H. Coulter Center for Translational Research at the University of Miami
dc.description.sponsorshipMiami Clinical and Translational Science Institute (CTSI)
dc.description.sponsorshipNational Institute of Allergy and Infectious Diseases, NIH
dc.description.sponsorshipDefense Advanced Research Projects Agency (DARPA) Autonomous Diagnostics to Enable Prevention and Therapeutics: Prophylactic Options to Environmental and Contagious Threats (ADEPT-PROTECT) program [W31P4Q-13-1-0011]
dc.identifier.citationSCIENCE TRANSLATIONAL MEDICINE, v.9, n.410, article ID eaan8184, 7p, 2017
dc.identifier.doi10.1126/scitranslmed.aan8184
dc.identifier.eissn1946-6242
dc.identifier.issn1946-6234
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/24186
dc.language.isoeng
dc.publisherAMER ASSOC ADVANCEMENT SCIENCE
dc.relation.ispartofScience Translational Medicine
dc.rightsrestrictedAccess
dc.rights.holderCopyright AMER ASSOC ADVANCEMENT SCIENCE
dc.subject.otherdengue virus
dc.subject.otherdependent enhancement
dc.subject.otherstructural basis
dc.subject.otherrhesus-monkeys
dc.subject.otherprotection
dc.subject.othervaccine
dc.subject.otherdisease
dc.subject.otherbinding
dc.subject.othermice
dc.subject.wosCell Biology
dc.subject.wosMedicine, Research & Experimental
dc.titleNeutralizing human monoclonal antibodies prevent Zika virus infection in macaques
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.affiliation.countryEstados Unidos
hcfmusp.affiliation.countryisous
hcfmusp.author.externalMAGNANI, Diogo M.:Univ Miami, Dept Pathol, Leonard M Miller Sch Med, Miami, FL 33136 USA
hcfmusp.author.externalROGERS, Thomas F.:Scripps Res Inst, Dept Immunol & Microbiol, La Jolla, CA 92037 USA; Scripps Res Inst, Int AIDS Vaccine Initiat Neutralizing Antibody Ct, La Jolla, CA 92037 USA
hcfmusp.author.externalBEUTLER, Nathan:Scripps Res Inst, Dept Immunol & Microbiol, La Jolla, CA 92037 USA; Scripps Res Inst, Int AIDS Vaccine Initiat Neutralizing Antibody Ct, La Jolla, CA 92037 USA
hcfmusp.author.externalRICCIARDI, Michael J.:Univ Miami, Dept Pathol, Leonard M Miller Sch Med, Miami, FL 33136 USA
hcfmusp.author.externalBAILEY, Varian K.:Univ Miami, Dept Pathol, Leonard M Miller Sch Med, Miami, FL 33136 USA
hcfmusp.author.externalGONZALEZ-NIETO, Lucas:Univ Miami, Dept Pathol, Leonard M Miller Sch Med, Miami, FL 33136 USA
hcfmusp.author.externalBRINEY, Bryan:Scripps Res Inst, Dept Immunol & Microbiol, La Jolla, CA 92037 USA; Scripps Res Inst, Int AIDS Vaccine Initiat Neutralizing Antibody Ct, La Jolla, CA 92037 USA
hcfmusp.author.externalSOK, Devin:Scripps Res Inst, Dept Immunol & Microbiol, La Jolla, CA 92037 USA; Scripps Res Inst, Int AIDS Vaccine Initiat Neutralizing Antibody Ct, La Jolla, CA 92037 USA
hcfmusp.author.externalLE, Khoa:Scripps Res Inst, Dept Immunol & Microbiol, La Jolla, CA 92037 USA; Scripps Res Inst, Int AIDS Vaccine Initiat Neutralizing Antibody Ct, La Jolla, CA 92037 USA
hcfmusp.author.externalSTRUBEL, Alexander:Scripps Res Inst, Dept Immunol & Microbiol, La Jolla, CA 92037 USA; Scripps Res Inst, Int AIDS Vaccine Initiat Neutralizing Antibody Ct, La Jolla, CA 92037 USA
hcfmusp.author.externalGUTMAN, Martin J.:Univ Miami, Dept Pathol, Leonard M Miller Sch Med, Miami, FL 33136 USA
hcfmusp.author.externalPEDRENO-LOPEZ, Nuria:Univ Miami, Dept Pathol, Leonard M Miller Sch Med, Miami, FL 33136 USA
hcfmusp.author.externalGRUBAUGH, Nathan D.:Scripps Res Inst, Dept Immunol & Microbiol, La Jolla, CA 92037 USA; Scripps Res Inst, Int AIDS Vaccine Initiat Neutralizing Antibody Ct, La Jolla, CA 92037 USA
hcfmusp.author.externalMAXWELL, Helen S.:Univ Miami, Dept Pathol, Leonard M Miller Sch Med, Miami, FL 33136 USA
hcfmusp.author.externalDOMINGUES, Aline:Univ Miami, Dept Pathol, Leonard M Miller Sch Med, Miami, FL 33136 USA
hcfmusp.author.externalMARTINS, Mauricio A.:Univ Miami, Dept Pathol, Leonard M Miller Sch Med, Miami, FL 33136 USA
hcfmusp.author.externalLEE, David E.:Emory Univ, Yerkes Natl Primate Res Ctr, Atlanta, GA 30329 USA
hcfmusp.author.externalOKWUAZI, Erica E.:Emory Univ, Yerkes Natl Primate Res Ctr, Atlanta, GA 30329 USA
hcfmusp.author.externalJEAN, Sherrie:Emory Univ, Yerkes Natl Primate Res Ctr, Atlanta, GA 30329 USA
hcfmusp.author.externalSTROBERT, Elizabeth A.:Emory Univ, Yerkes Natl Primate Res Ctr, Atlanta, GA 30329 USA
hcfmusp.author.externalCHAHROUDI, Ann:Emory Univ, Yerkes Natl Primate Res Ctr, Atlanta, GA 30329 USA; Emory Univ, Dept Pediat, Atlanta, GA 30322 USA
hcfmusp.author.externalSILVESTRI, Guido:Emory Univ, Yerkes Natl Primate Res Ctr, Atlanta, GA 30329 USA
hcfmusp.author.externalVANDERFORD, Thomas H.:Emory Univ, Yerkes Natl Primate Res Ctr, Atlanta, GA 30329 USA
hcfmusp.author.externalDESROSIERS, Ronald C.:Univ Miami, Dept Pathol, Leonard M Miller Sch Med, Miami, FL 33136 USA
hcfmusp.author.externalBONALDO, Myrna C.:Fiocruz MS, Lab Biol Mol Flavivirus, Inst Oswaldo Cruz, BR-21040360 Rio De Janeiro, Brazil
hcfmusp.author.externalWHITEHEAD, Stephen S.:NIAID, Infect Dis Lab, NIH, Bethesda, MD 20892 USA
hcfmusp.author.externalBURTON, Dennis R.:Scripps Res Inst, Dept Immunol & Microbiol, La Jolla, CA 92037 USA; Scripps Res Inst, Int AIDS Vaccine Initiat Neutralizing Antibody Ct, La Jolla, CA 92037 USA; Ragon Inst MGH MIT & Harvard, Cambridge, MA 02139 USA
hcfmusp.author.externalWATKINS, David I.:Univ Miami, Dept Pathol, Leonard M Miller Sch Med, Miami, FL 33136 USA
hcfmusp.citation.scopus72
hcfmusp.contributor.author-fmusphcCASSIA GISELE TERRASSANI SILVEIRA
hcfmusp.contributor.author-fmusphcESPER GEORGES KALLAS
hcfmusp.description.articlenumbereaan8184
hcfmusp.description.issue410
hcfmusp.description.volume9
hcfmusp.origemWOS
hcfmusp.origem.pubmed28978754
hcfmusp.origem.scopus2-s2.0-85030571167
hcfmusp.origem.wosWOS:000412167400005
hcfmusp.publisher.cityWASHINGTON
hcfmusp.publisher.countryUSA
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