HBV carrying drug-resistance mutations in chronically infected treatment-naive patients

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorGOMES-GOUVEA, Michele S.
dc.contributor.authorFERREIRA, Ariana C.
dc.contributor.authorTEIXEIRA, Rosangela
dc.contributor.authorANDRADE, Jose R.
dc.contributor.authorFERREIRA, Adalgisa S. P.
dc.contributor.authorBARROS, Lena M. F.
dc.contributor.authorREZENDE, Rosamar E. F.
dc.contributor.authorNASTRI, Ana C. S. Santos
dc.contributor.authorLEITE, Andrea G. B.
dc.contributor.authorPICCOLI, Leonora Z.
dc.contributor.authorGALVAN, Josiane
dc.contributor.authorCONDE, Simone R. S. S.
dc.contributor.authorSOARES, Manoel C. P.
dc.contributor.authorKLIEMANN, Dimas A.
dc.contributor.authorBERTOLINI, Dennis A.
dc.contributor.authorKUNYOSHI, Aline S. O.
dc.contributor.authorLYRA, Andre C.
dc.contributor.authorOIKAWA, Marcio K.
dc.contributor.authorARAUJO, Luciano V. de
dc.contributor.authorCARRILHO, Flair J.
dc.contributor.authorMENDES-CORREA, Maria C. J.
dc.contributor.authorPINHO, Joao R. Rebello
dc.date.accessioned2015-10-26T16:27:30Z
dc.date.available2015-10-26T16:27:30Z
dc.date.issued2015
dc.description.abstractBackground: Nucleoside/nucleotide analogue (NA) treatment causes selection pressure for HBV strains carrying mutations conferring NA resistance. Drug-resistance mutations occur in the reverse transcriptase (RT) region of the HBV polymerase gene and spontaneously arise during viral replication. These mutations can also alter the hepatitis B surface (HBs) protein and in some cases reduce binding to HBs antibodies. The spread of NA-resistant HBV may impact the efficacy of antiviral treatment and hepatitis B immunization programmes. In this study, we used direct sequencing to assess the occurrence of HBV carrying known mutations that confer NA resistance in the largest cohort of treatment-naive patients with chronic hepatitis B (CHB) to date. Methods: HBV DNA samples isolated from 702 patients were sequenced and the RT region subjected to mutational analysis. Results: There was high genetic variability among the HBV samples analysed: A1 (63.7%), D3 (14.5%), A2 (3.3%), A3 (0.1%), B1 (0.1%), B2 (0.1%), C2 (0.9%), D1 (0.9%), D2 (4.6%), D4 (5.1%), D unclassified sub-genotype (0.7%), E (0.6%), F2a (4.6%), F4 (0.4%) and G (0.4%). HBV strains harbouring mutations conferring NA resistance alone or combined with compensatory mutations were identified in 1.6% (11/702) of the patients. Conclusions: HBV strains harbouring resistance mutations can comprise the major population of HBV quasispecies in treatment-naive patients. In Brazil, there is a very low frequency of untreated patients who are infected with these strains. These findings suggest that the spread and natural selection of drug-resistant HBV is an uncommon event and/or most of these strains remain unstable in the absence of NA selective pressure.
dc.description.indexMEDLINE
dc.description.sponsorshipFAPESP (Sao Paulo Research Foundation) [2010/50081-9, 2010/51208-2]
dc.description.sponsorshipAlves de Queiroz Family Fund
dc.identifier.citationANTIVIRAL THERAPY, v.20, n.4, p.387-395, 2015
dc.identifier.doi10.3851/IMP2938
dc.identifier.issn1359-6535
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/11660
dc.language.isoeng
dc.publisherINT MEDICAL PRESS LTD
dc.relation.ispartofAntiviral Therapy
dc.rightsrestrictedAccess
dc.rights.holderCopyright INT MEDICAL PRESS LTD
dc.subject.otherhepatitis-b-virus
dc.subject.otherreverse-transcriptase sequences
dc.subject.otherlamivudine-resistance
dc.subject.otheradefovir dipivoxil
dc.subject.othermolecular characterization
dc.subject.otherreduced antigenicity
dc.subject.otherantiviral therapy
dc.subject.otherpolymerase gene
dc.subject.others gene
dc.subject.othermutants
dc.subject.wosInfectious Diseases
dc.subject.wosPharmacology & Pharmacy
dc.subject.wosVirology
dc.titleHBV carrying drug-resistance mutations in chronically infected treatment-naive patients
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalTEIXEIRA, Rosangela:Univ Fed Minas Gerais, Sch Med, Dept Internal Med, Belo Horizonte, MG, Brazil
hcfmusp.author.externalANDRADE, Jose R.:Univ Fed Minas Gerais, Sch Med, Dept Internal Med, Belo Horizonte, MG, Brazil
hcfmusp.author.externalFERREIRA, Adalgisa S. P.:Univ Fed Maranhao, Clin Res Ctr, Sao Luis, Maranhao, Brazil
hcfmusp.author.externalBARROS, Lena M. F.:Univ Fed Maranhao, Clin Res Ctr, Sao Luis, Maranhao, Brazil
hcfmusp.author.externalREZENDE, Rosamar E. F.:Municipal Secretary Hlth, Sao Paulo, Brazil
hcfmusp.author.externalCONDE, Simone R. S. S.:Fundacao Santa Casa Misericordia Para, Belem, Para, Brazil
hcfmusp.author.externalSOARES, Manoel C. P.:Inst Evandro Chagas, Serv Hepatol, Ananindeua, Para, Brazil
hcfmusp.author.externalKLIEMANN, Dimas A.:Hosp Nossa Senhora da Conceicao, Serv Infectol, Porto Alegre, RS, Brazil
hcfmusp.author.externalBERTOLINI, Dennis A.:Univ Estadual Maringa, Lab Imunol Clin, Dept Anal Clin & Biomed, Maringa, Parana, Brazil
hcfmusp.author.externalKUNYOSHI, Aline S. O.:Univ Estadual Maringa, Lab Imunol Clin, Dept Anal Clin & Biomed, Maringa, Parana, Brazil
hcfmusp.author.externalLYRA, Andre C.:Univ Fed Bahia, Dept Med, Div Gastroenterol & Hepatol, BR-41170290 Salvador, BA, Brazil
hcfmusp.author.externalOIKAWA, Marcio K.:Univ Fed ABC, Ctr Matemat Comp & Cognicao, Sao Paulo, Brazil
hcfmusp.author.externalARAUJO, Luciano V. de:Univ Sao Paulo, Escola Artes Ciencias & Humanidades, Sao Paulo, Brazil
hcfmusp.citation.scopus33
hcfmusp.contributor.author-fmusphcMICHELE SOARES GOMES GOUVEA
hcfmusp.contributor.author-fmusphcARIANA CAROLINA FERREIRA
hcfmusp.contributor.author-fmusphcANA CATHARINA DE SEIXAS SANTOS NASTRI
hcfmusp.contributor.author-fmusphcFLAIR JOSE CARRILHO
hcfmusp.contributor.author-fmusphcMARIA CASSIA JACINTHO MENDES CORREA
hcfmusp.contributor.author-fmusphcJOAO RENATO REBELLO PINHO
hcfmusp.description.beginpage387
hcfmusp.description.endpage395
hcfmusp.description.issue4
hcfmusp.description.volume20
hcfmusp.origemWOS
hcfmusp.origem.pubmed25624410
hcfmusp.origem.scopus2-s2.0-84945261366
hcfmusp.origem.wosWOS:000359911300004
hcfmusp.publisher.cityLONDON
hcfmusp.publisher.countryENGLAND
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