AUTOLOGOUS CHONDROCYTE IMPLANTATION IN BRAZIL

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorGIGLIO, Pedro Nogueira
dc.contributor.authorLIZIER, Nelson Foresto
dc.contributor.authorLEVY, Debora
dc.contributor.authorSOBRADO, Marcel Faraco
dc.contributor.authorGOBBI, Riccardo Gomes
dc.contributor.authorPECORA, Jose Ricardo
dc.contributor.authorBYDLOWSKI, Sergio Paulo
dc.contributor.authorDEMANGE, Marco Kawamura
dc.date.accessioned2020-08-20T13:19:45Z
dc.date.available2020-08-20T13:19:45Z
dc.date.issued2020
dc.description.abstractObjective: To describe the first series of cases of autologous chondrocyte implantation (ACI) in collagen membrane performed in Brazil. Methods: ACI was performed in 12 knees of 11 patients, aged 32.1 +/- 10.9 years, with 5.3 +/- 2.6 cm(2) full-thickness knee cartilage lesions, with a six-month minimum follow-up. Two surgical procedures were performed: arthroscopic cartilage biopsy for isolation and expansion of chondrocytes, which were seeded onto collagen membrane and implanted in the lesion site; the characterization of cultured cells and implant was performed using immunofluorescence for type II collagen (COL2) for cell viability and electron microscopy of the implant. Clinical safety, KOOS and IKDC scores and magnetic resonance imaging were evaluated. We used repeated-measures ANOVA and post-hoc comparisons at alpha = 5%. Results: COL2 was identified in the cellular cytoplasm, cell viability was higher than 95% and adequate distribution and cell adhesion were found in the membrane. The median follow-up was 10.9 months (7 to 19). We had two cases of arthrofibrosis, one of graft hypertrophy and one of superficial infection as complications, but none compromising clinical improvement. KOOS and IKDC ranged from 71.2 +/- 11.44 and 50.72 +/- 14.10, in preoperative period, to 85.0 +/- 4.4 and 70.5 +/- 8.0, at 6 months (p = 0.007 and 0.005). MRI showed regenerated tissue compatible with hyaline cartilage. Conclusion: ACI in collagen membrane was feasible and safe in a short-term follow- up, presenting regenerated formation visualized by magnetic resonance imaging and improved clinical function.eng
dc.description.indexPubMedeng
dc.identifier.citationACTA ORTOPEDICA BRASILEIRA, v.28, n.3, p.131-136, 2020
dc.identifier.doi10.1590/1413-785220202803226503
dc.identifier.eissn1809-4406
dc.identifier.issn1413-7852
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/36694
dc.language.isoeng
dc.publisherATHA COMUNICACAO & EDITORAeng
dc.relation.ispartofActa Ortopedica Brasileira
dc.rightsopenAccesseng
dc.rights.holderCopyright ATHA COMUNICACAO & EDITORAeng
dc.subjectCartilageeng
dc.subjectCelleng
dc.subjectand Tissue-Based Therapyeng
dc.subjectTransplantation, Autologouseng
dc.subjectChondrocyteseng
dc.subject.othergraft hypertrophyeng
dc.subject.othercartilage repaireng
dc.subject.otherrehabilitationeng
dc.subject.othergenerationeng
dc.subject.otherguidelineseng
dc.subject.otherkneeeng
dc.subject.wosOrthopedicseng
dc.titleAUTOLOGOUS CHONDROCYTE IMPLANTATION IN BRAZILeng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.author.externalLIZIER, Nelson Foresto:Ctr Criogenia Brasil, Sao Paulo, SP, Brazil
hcfmusp.citation.scopus0
hcfmusp.contributor.author-fmusphcPEDRO NOGUEIRA GIGLIO
hcfmusp.contributor.author-fmusphcDEBORA LEVY
hcfmusp.contributor.author-fmusphcMARCEL FARACO SOBRADO
hcfmusp.contributor.author-fmusphcRICCARDO GOMES GOBBI
hcfmusp.contributor.author-fmusphcJOSE RICARDO PECORA
hcfmusp.contributor.author-fmusphcSERGIO PAULO BYDLOWSKI
hcfmusp.contributor.author-fmusphcMARCO KAWAMURA DEMANGE
hcfmusp.description.beginpage131
hcfmusp.description.endpage136
hcfmusp.description.issue3
hcfmusp.description.volume28
hcfmusp.origemWOS
hcfmusp.origem.pubmed32536794
hcfmusp.origem.scieloSCIELO:S1413-78522020000300131
hcfmusp.origem.scopus2-s2.0-85088657321
hcfmusp.origem.wosWOS:000536307800007
hcfmusp.publisher.citySAO PAULO SPeng
hcfmusp.publisher.countryBRAZILeng
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hcfmusp.scopus.lastupdate2024-05-10
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